Cancer prevention and therapy with kiwifruit in Chinese folklore medicine: a study of kiwifruit extracts

Motohashi, Noboru; Shirataki, Yoshiaki; Kawase, Masami; Tani, Shigemasa; Sakagami, Hiroshi; Satoh, Kazue; Kurihara, Teruo; Nakashima, Hideki; Mucsi, Ilona; Varga, A; Molnár, Joséph

doi:10.1016/s0378-8741(02)00125-3

Cited by 104 publications

(49 citation statements)

References 8 publications

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“…[3][4][5] Kiwifruit have also been used for the treatment of cancers in Chinese folk medicine. 6) For example, many different cancers, especially cancers of the digestive system (mainly stomach cancer), lung, and liver, have been treated with kiwifruit prescriptions due to its cytotoxic and antioxidant activities. 6,7,[10][11][12] Atherosclerosis is a complex multifactorial process involving oxidation of cholesterol and the intracellular accumulation of oxidized cholesterol, high blood pressure, and platelet aggregation.…”

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confidence: 99%

“…6) For example, many different cancers, especially cancers of the digestive system (mainly stomach cancer), lung, and liver, have been treated with kiwifruit prescriptions due to its cytotoxic and antioxidant activities. 6,7,[10][11][12] Atherosclerosis is a complex multifactorial process involving oxidation of cholesterol and the intracellular accumulation of oxidized cholesterol, high blood pressure, and platelet aggregation. Many natural products with bioactive constituents such as antioxidants can ameliorate this process and prevent cardiovascular disease at many steps in the process.…”

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confidence: 99%

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Cardiovascular Protective Properties of Kiwifruit Extracts in Vitro

Jung

Song

Han

et al. 2005

Biological & Pharmaceutical Bulletin

106

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It is currently accepted that the consumption of fruit-derived antioxidants such as vitamin C, carotenoids, and flavonoids provides a preventive effect against cardiovascular disease. The purpose of the present study was to investigate potential cardiovascular protective properties of aqueous and 70% ethanol extracts from kiwifruit by analyzing the antioxidative, antihypertensive, hypocholesterolemic, and fibrinolytic activities in vitro. Aqueous and 70% ethanol extracts at 50 mg/ml showed DPPH-radical scavenging activities of 72.31% and 70.75%, respectively. Total antioxidant activity in linoleic acid emulsion was 85-88% at 10 mg/ml and 96-98% at 50 mg/ml of kiwifruit extract. Inhibitory activities against angiogensin I-converting enzyme of kiwifruit extracts were 21-26% at 10 mg/ml and 46-49% at 50 mg/ml, and inhibitory activities on HMG-CoA reductase were 13-14% at 10 mg/ml and 19-30% at 50 mg/ml. Fibrinolytic activity of kiwifruit was also observed at a high concentration of 100 mg/ml in both aqueous and 70% EtOH extracts. Based on our results, kiwifruit have potential cardiovascular protective properties in vitro.

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confidence: 99%

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Cardiovascular Protective Properties of Kiwifruit Extracts in Vitro

Jung

Song

Han

et al. 2005

Biological & Pharmaceutical Bulletin

106

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“…국내 육성 참다래 품종들이 뉴질랜드 기 원 품종들보다 acetylcholinesterase와 butyrylcholinesterase 활성을 더 억제하였다 (Lim et al, 2014). 또한, 참다래의 섭 취는 암, 심혈관질환 등과 같은 퇴행성 질환의 예방에 도움 이 될 수 있다 (Motohashi et al, 2002). 참다래의 유전형 (genotype), 품종(cultivar)에 따라 미네랄, 비타민, 페놀성 화 합물의 함량 및 조성이 다르다고 보고되었다 (Samadi-Maybodi and Shariat, 2003;Nishiyama et al, 2004;Nishiyama et al, 2005;Du et al, 2009;Kim et al, 2009 Table 2).…”

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Antioxidant Capacity and Protective Effects on Neuronal PC-12 Cells of Domestic Bred Kiwifruit

Lee¹,

Lee²,

Eom³

et al. 2015

HST

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This study was conducted to comparatively evaluate antioxidant capacity (AC) of seven cultivars of kiwifruit (Actinidia spp.) and their protective effects on neuronal PC-12 cells. The contents of total phenolics (TP) and total flavonoids (TF) of kiwifruits were also examined. Five cultivars of kiwifruit, Actinidia chinensis (cv. Haehyang and cv. Haegeum), A. eriantha (cv. Bidan), A. arguta × A. deliciosa (cv. Mansoo), and A. arguta (cv. Chiak), were bred in Korea, while two cultivars, A. deliciosa (cv. Hayward) and A. linguiensis (accession number 041AE), originated from New Zealand and China, respectively. Skin extracts of kiwifruit showed higher TP, TF, and AC than flesh extracts. The highest levels of TP and AC were found in cv. Bidan flesh extract among cultivars studied, but the TF content of cv. Bidan flesh extract was the lowest. The kiwifruit bred in Korea had higher AC than their counterparts. AC of kiwifruit had a highly positive linear correlation with TP and TF. The flesh extracts from cv. Hayward, cv. Haehyang, and cv. Haegeum significantly (p < 0.05) prevented PC-12 cells from oxidative stress induced using H2O2 compared to a control with H2O2 only. Overall, our results suggest that kiwifruit bred in Korea may offer a good source of antioxidants and serve as functional materials.

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“…It was later introduced in New Zealand and California, where the first major planting occurred in 1960. Some clinical effects of kiwifruit ingredients such as ascorbic acid (as a scavenger), antibacterial agents, and actinidin (a potent protein-dissolving enzyme) have been reported in the literature [5][6][7]. The proteolytic activities of actinidin and papain (proteolytic enzyme in papaya) are well-known commercially for meat tenderizing.…”

Section: Introductionmentioning

confidence: 99%

Effect of Wound Dressing with Fresh Kiwifruit on healing of Cutaneous Wound in Rats

Goudarzi

Lashkarbolouki

Khorshidi

et al. 2015

Zahedan J Res Med Sci

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Background:The kiwi fruit is known to have dramatic antibacterial, debridement, wound contracture, and angiogenic effects. We propose that kiwifruit is an ideal candidate to enhance the process of wound healing. The present study assessed the effects of wound kiwifruit dressing on cutaneous wound healing in rat. Materials and Methods: In this experimental study, 30 male Wistar rats were randomly divided into 2 groups of control and kiwifruit group. A full-thickness dermal incision (35mm length) was made on the right side of the paravertebral region. In the control group, one day after wound induction wounds was dressed with Vaseline sterile gauze after normal saline irrigation. In the second group, the wounds were dressed with kiwifruit. Wound healing was evaluated by measuring surface area, percentage of healing, duration of healing, and wound tensile strength. Results: Obtained results showed that the duration of wound healing in kiwi group in comparison with the control was significantly decreased. The amount of wound healing in percent was also significantly different between control and kiwi groups at days 3, 6 (p<0.001), 9 (p<0.05), 12 and 14 (p<0.01). Comparisons of wound length between control and kiwi group per day showed that kiwi group had significantly lower wound length on day 9, 12, 14 and 16 (p<0.01, 0.001, 0.01 and 0.01, respectively) in comparisons to control group. Also, the wound tensile strength in kiwi group also was significantly greater than the control animals (p<0.01). Conclusion:We concluded that our study provides some evidence to support the use of kiwi to accelerate wound healing.

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Cancer prevention and therapy with kiwifruit in Chinese folklore medicine: a study of kiwifruit extracts

Cited by 104 publications

References 8 publications

Cardiovascular Protective Properties of Kiwifruit Extracts in Vitro

Cardiovascular Protective Properties of Kiwifruit Extracts in Vitro

Antioxidant Capacity and Protective Effects on Neuronal PC-12 Cells of Domestic Bred Kiwifruit

Effect of Wound Dressing with Fresh Kiwifruit on healing of Cutaneous Wound in Rats

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