Cancer protective effects of plums: A systematic review

Bahrin, Abdul Alim; Moshawih, Said; Dhaliwal, Jagjit Singh; Kanakal, Mahibub Mahahamadsa; Khan, Abdullah; Lee, Kah Seng; Goh, Bey Hing; Goh, Hui Poh; Kifli, Nurolaini; Ming, Long Chiau

doi:10.1016/j.biopha.2021.112568

Cited by 23 publications

(14 citation statements)

References 63 publications

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“…The phloretin from apples may be an important anticancer phytochemical based on the results obtained in experiments on the breast, prostate, cervical, lung, esophageal, gastric and blood cancers [ 20 ]. The cell viability and proliferation of colon cancers were significantly reduced by plum extracts [ 21 ]. The extract obtained from the plum pulp reduced the in vitro proliferation and viability of the A375 melanoma cells [ 22 ].…”

Section: Discussionmentioning

confidence: 99%

Extracts of Common Vegetables Inhibit the Growth of Ovary Cancer Cells

Furdak

Pieńkowska

Bartosz

et al. 2022

Foods

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There is recent interest in a diet that can be recommended for patients suffering from cancer. In this respect, the effects were studied of the extracts of several common fruits, herbs and vegetables on the viability of two human ovary cancer cell lines (SKOV-3 and PEO1) in vitro. Normal human MRC-5 fibroblasts were used as a control cell line. The extracts of garlic, horseradish and curly kale as well as green and black tea were the most effective in lowering the viability of ovarian cancer cells, while not affecting the viability of MRC-5 fibroblasts. Except for garlic and horseradish, the cytotoxic effects of the extracts correlated with their polyphenol content. The examination of changes in the content of ATP and glutathione, in the level of reactive oxygen species, mitochondrial potential and mitochondrial mass did not show a consistent pattern, suggesting that various extracts may act via different mechanisms. Although the extracts’ toxicity to cells in vitro is a first and direct suggestion concerning their possible anticancer effects in vivo, these results point to potential vegetable candidates to become diet components recommended for ovary cancer patients.

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Section: Discussionmentioning

confidence: 99%

Extracts of Common Vegetables Inhibit the Growth of Ovary Cancer Cells

Furdak

Pieńkowska

Bartosz

et al. 2022

Foods

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“…Previous studies reported that plum extracts exhibited the ability to decrease the viability and proliferation of hepatocellular and colon cancer cell lines, and at a high concentration of plum extract (2 mg/ml), 87% of grown inhibition was observed ([ 36 , 37 ]). Plum extract was reported to induce the cleaved caspase-8 protein expression which is responsible for inducing cancer cell apoptosis [ 38 ]. Plum extract was also reported to inhibit the cancer cell migration [ 39 ].…”

Section: Resultsmentioning

confidence: 99%

Determination of Phenolic Compounds and Bioactive Potential of Plum (Prunus salicina) Peel Extract Obtained by Ultrasound‐Assisted Extraction

Jawad

Ali

Qasim

et al. 2022

BioMed Research International

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Ultrasound-assisted extraction (UAE) of bioactive compounds from black plum peels was optimized by response surface methodology (RSM). Temperature (35-55°C), time (15-45 min), and ethanol concentration (50-90%) were selected as independent extraction parameters, whereas total anthocyanin content (TAC), total phenolic content (TPC), and 2,2-diphenyl-1-picrylhydrazyl (DPPH) inhibition were kept as response variables. The optimized extraction conditions were determined by RSM as extraction at 49°C for 37 min with 68% ethanol, which corresponded to TAC, TPC, and DPPH inhibition values of 5.42 ± 0.61 mg/g, 6.217 ± 0.76 mg GAE/g, and 89 ± 2.13 % , respectively. Fourier-transform infrared spectrometer (FTIR), high-performance liquid chromatography (HPLC), and gas chromatography mass spectrometer (GCMS) were used for chemical characterization of optimized plum peel extract (PPE). Optimized PPE was further evaluated for antibacterial, antioxidant, anticancer, and food preservation potential. PPE showed 92.31% DPPH inhibition with IC50 value of 360.6 μg/ml. Optimized PPE extract was effective in the inhibition of cancer cell proliferation and migration, and IC50 values were in the range 1.85-3.96 mg/ml for different human cancer cell lines. Major phenolics identified in PPE were ferulic acid (47.87 mg/kg), sinapic acid (9.15 mg/kg), quercetin (7.44 mg/kg), gallic acid (3.24 mg/kg), m-coumaric acid (2.59 mg/kg), and vanillic acid (1.12 mg/kg). PPE extract inhibited the growth of various foodborne bacterial pathogens and increased the shelf life of PPE coated fresh grapes. PPE due to antibacterial, anticancer, antioxidant, and food preservation potential can be used in developing functional food and pharmaceutical products.

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“…Over 400 species in the Prunus genus belong to the Rosacae family, but only 89 are listed in the Genetic Resources Information System [1]. The main representatives of the Prunus genus are plums, cherries, peaches, apricots, and almonds [2].…”

Section: Introductionmentioning

confidence: 99%

“…The fruits are valued for sensory reasons (taste and smell) and technological properties (attractive and desirable products). The most commonly grown cultivars are European plum (Prunus domestica L.) and Japanese plum (Prunus salicina) [1]. P. domestica fruits come in different skin and flesh colours, which, depending on the cultivar, range from dark purple-red, red to yellow or yellowish-green.…”

Section: Introductionmentioning

confidence: 99%

Inhibition of α-Amylase, α-Glucosidase, Pancreatic Lipase, 15-Lipooxygenase and Acetylcholinesterase Modulated by Polyphenolic Compounds, Organic Acids, and Carbohydrates of Prunus domestica Fruit

Rybak

2023

Antioxidants

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This work aimed to establish the content of phenolic compounds, carbohydrates, and organic acids and to determine their potential to inactivate α-amylase, α-glucosidase, pancreatic lipase, 15-lipoxygenase (15-LOX), acetylcholinesterase (AChE), and butyrylcholinesterase (BuChE), and antioxidant activity (ABTSo+ and FRAP) in 43 Prunus domestica cultivars. We identified 20 phenolic compounds, including, in the order of abundance, polymeric procyanidins, flavan-3-ols, phenolic acids, flavonols, and anthocyanins. The total content of phenolic compounds varied depending on the cultivar and ranged from 343.75 to 1419 mg/100 g d.w. The cultivars of Ś2, Ś11, and Ś16 accumulated the greatest amounts of polyphenols, while in cvs. Ś42, Ś35, and Ś20 polyphenols were the least abundant. The highest antioxidant potential of 7.71 (ABTSo+) and 13.28 (FRAP) mmoL Trolox/100 g d.w. was confirmed for cv. Ś11. P. domestica fruits showed inhibitory activity toward α-amylase (2.63–61.53), α-glucosidase (0.19–24.07), pancreatic lipase (0.50–8.20), and lipoxygenase (15-LOX; 4.19–32.67), expressed as IC50 (mg/mL). The anti-AChE effect was stronger than the anti-BuChE one. Cv. Ś3 did not inhibit AChE activity, while cv. Ś35 did not inhibit BuChE. Thanks to the abundance of biologically active compounds, P. domestica offers several health-promoting benefits and may prevent many diseases. For these reasons, they are worth introducing into a daily diet.

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Cancer protective effects of plums: A systematic review

Cited by 23 publications

References 63 publications

Extracts of Common Vegetables Inhibit the Growth of Ovary Cancer Cells

Extracts of Common Vegetables Inhibit the Growth of Ovary Cancer Cells

Determination of Phenolic Compounds and Bioactive Potential of Plum (Prunus salicina) Peel Extract Obtained by Ultrasound‐Assisted Extraction

Inhibition of α-Amylase, α-Glucosidase, Pancreatic Lipase, 15-Lipooxygenase and Acetylcholinesterase Modulated by Polyphenolic Compounds, Organic Acids, and Carbohydrates of Prunus domestica Fruit

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