Extracts of Common Vegetables Inhibit the Growth of Ovary Cancer Cells

Furdak, Paulina; Pieńkowska, Natalia; Bartosz, Grzegorz; Sadowska-Bartosz, Izabela

doi:10.3390/foods11162518

Cited by 8 publications

(4 citation statements)

References 61 publications

(59 reference statements)

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“…The strong inhibition of the proliferation of PEO1 cells by PBS extracts of fresh Spanish garlic is in general agreement with the results of our previous study [ 56 ] in which such extracts were used. We found previously 50% inhibition of the proliferation of PEO1 cells by a PBS extract from Spanish garlic at a concentration corresponding to 0.31 μg extract/100 μL (using a different batch of garlic).…”

Section: Discussionsupporting

confidence: 92%

“…When comparing the effects of extracts of various fruits and vegetables on the proliferation of ovarian cancer cells, we found an exceptional antiproliferation ability of aqueous garlic extracts. The proliferation of PEO1 and SKOV3 ovarian cancer cells was 50% inhibited by extracts from 1.11 and 3.33 μg of garlic per 100 μL medium, respectively [ 56 ]. The aim of the present study was to examine how this antiproliferative activity of garlic extracts varies within various garlic cultivars and preparations available commercially, and how it depends on the solvent used for extraction.…”

Section: Introductionmentioning

confidence: 99%

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Comparison of Antioxidant and Antiproliferative Effects of Various Forms of Garlic and Ramsons

Furdak,

Pieńkowska,

Kapusta

et al. 2023

Molecules

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Garlic is known to be rich in antioxidants, inhibit the proliferation of various cancer cells, and hamper cancer formation and growth, but various forms of garlic can differ greatly in these respects. This study aimed to compare the antioxidant properties of acetone, ethanol, and aqueous extracts of fresh Polish and Spanish garlic, black and granulated garlic, as well as fresh and dried ramsons. Extracts of black and granulated garlic showed the lowest total antioxidant capacity (TAC). The content of phenolic compounds correlated with TAC measured by ABTS• decolorization and FRAP methods, and with the results of FRAP and DPPH• decolorization assays. Garlic extracts inhibited the proliferation of PEO1 and SKOV3 ovarian cancer cells and, usually to a smaller extent, MRC-5 fibroblasts. PBS extracts of fresh Spanish garlic showed the highest potency for inhibition of proliferation of PEO1 cells (IC50 of 0.71 µg extract dry mass/100 µL medium). No significant correlation was found between the potency for inhibition of proliferation and the content of phenolics or flavonoids, confirming that phenolics are the main determinants of TAC but do not contribute significantly to the antiproliferative effects of garlic.

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Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Comparison of Antioxidant and Antiproliferative Effects of Various Forms of Garlic and Ramsons

Furdak,

Pieńkowska,

Kapusta

et al. 2023

Molecules

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“…There is only rare evidence of anticancer activity of wild Brassica species [ 6 ] and flat-leaved kale [ 36 , 47 ]. Although glucosinolates are mostly reported as bioactive molecules with anticancer activity [ 24 , 25 ], Furdak et al [ 51 ] showed that the cytotoxic effects of a number of plant extracts, including white cabbage extracts, also correlated with their polyphenol content. Sinapic acid and ferulic acid, found at a high level in Brassica species, are strong antioxidants with reported anticancer activity [ 52 , 53 , 54 , 55 ].…”

Section: Discussionmentioning

confidence: 99%

Antioxidant and Antiproliferative Activities of Kale (Brassica oleracea L. Var. acephala DC.) and Wild Cabbage (Brassica incana Ten.) Polyphenolic Extracts

et al. 2023

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Brassicaceae are rich in healthy phytochemicals that have a positive impact on human health. The aim of this study was to analyze the phenolic compounds and antioxidant and anticancer potential of traditional Croatian kale (Brassica oleracea L. var. acephala DC.) and wild cabbage (Brassica incana Ten.) extracts. The phenolic groups and antioxidant activity were determined by spectrophotometry, selected phenolic compounds (ferulic acid, sinapic acid, salicylic acid, kaempferol, and quercetin) were analyzed by LC-MS/MS, and anticancer potential was evaluated in vitro using HeLa cells. The extracts of both plant species are rich in phenolic compounds and showed significant antioxidant activity at similar levels. LC-MS/MS detected sinapic acid as the most abundant phenolic acid, followed by ferulic acid, while salicylic acid was present at lower concentrations. A comparative analysis showed that wild cabbage contained significantly more sinapic acid, while kale contained more kaempferol and quercetin. Both Brassica extracts at a concentration of 50 µg mL−1 showed an antiproliferative effect on HeLa cells, while they did not affect the proliferation of normal human skin fibroblasts. Wild cabbage extract also showed an antiproliferative effect on HeLa cells at a lower applied concentration of 10 µg mL−1 of extracts. The clonogenic analysis also revealed the inhibitory effect of the extracts on HeLa colony growth.

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“…Garlic ( Allium sativum L.) is a traditional food grown worldwide, both as a flavoring and medicinal food [ 1 , 2 , 3 , 4 , 5 , 6 , 7 ], with a harvested area of 1.63 million hectares worldwide [ 8 ]. Currently, the harvesting and post-processing of garlic in China are primarily carried out manually, which is labor-intensive and inefficient.…”

Section: Introductionmentioning

confidence: 99%

Experimental Study of Garlic Root Cutting Based on Deep Learning Application in Food Primary Processing

Yang

Zhang

et al. 2022

Foods

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Garlic root cutting is generally performed manually; it is easy for the workers to sustain hand injuries, and the labor efficiency is low. However, the significant differences between individual garlic bulbs limit the development of an automatic root cutting system. To address this problem, a deep learning model based on transfer learning and a low-cost computer vision module was used to automatically detect garlic bulb position, adjust the root cutter, and cut garlic roots on a garlic root cutting test bed. The proposed object detection model achieved good performance and high detection accuracy, running speed, and detection reliability. The visual image of the output layer channel of the backbone network showed the high-level features extracted by the network vividly, and the differences in learning of different networks clearly. The position differences of the cutting lines predicted by different backbone networks were analyzed through data visualization. The excellent and stable performance indicated that the proposed model had learned the correct features in the data of different brightness. Finally, the root cutting system was verified experimentally. The results of three experiments with 100 garlic bulbs each indicated that the mean qualified value of the system was 96%. Therefore, the proposed deep learning system can be applied in garlic root cutting which belongs to food primary processing.

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Extracts of Common Vegetables Inhibit the Growth of Ovary Cancer Cells

Cited by 8 publications

References 61 publications

Comparison of Antioxidant and Antiproliferative Effects of Various Forms of Garlic and Ramsons

Comparison of Antioxidant and Antiproliferative Effects of Various Forms of Garlic and Ramsons

Antioxidant and Antiproliferative Activities of Kale (Brassica oleracea L. Var. acephala DC.) and Wild Cabbage (Brassica incana Ten.) Polyphenolic Extracts

Experimental Study of Garlic Root Cutting Based on Deep Learning Application in Food Primary Processing

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