Cancer risk in patients with candidiasis: a nationwide population-based cohort study

Chung, Li Min; Liang, Ji An; Lin, Cheng Li; Sun, Li; Kao, Chia Hung

doi:10.18632/oncotarget.18855

Cited by 64 publications

(54 citation statements)

References 28 publications

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“…Moreover, a negative correlation between Candida and Campylobacter in HIV-infected patients was also reported in this study, whereas in healthy subjects, no correlation between Candida and bacterial species was found [47]. Candida species is a well-known oral fungal pathogen, and studies have shown that infection with this species can significantly increase overall and some individual cancer risks, for example, head and neck, pancreatic, skin, and thyroid cancers [48]. A study in colorectal cancer patients has revealed dysbiosis in mycobiome characterised by change in fungal composition and ecology, which suggests the important role of gut mycobiome also in CRC [49].…”

Section: Role Of Microbiota In Cancersupporting

confidence: 54%

Role of Microbiome in Modulating Immune Responses in Cancer

Bose

Mukherjee

2019

Mediators of Inflammation

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The complex interactions between genes and the environment play important roles in disease susceptibility and progression. One of the chronic diseases that is affected by this gene-environment interplay is cancer. However, our knowledge about these environmental factors remains limited. The microorganisms that inhabit our bodies have recently been acknowledged to play a crucial role as an environmental factor, to which we are constantly exposed. Studies have revealed significant differences in the relative abundance of certain microbes in cancer cases compared with controls. It has been reported that changes in the composition of normal gut microbiota can increase/decrease cancer susceptibility and progression by diverse mechanisms including, but not limited to, inflammation—a well-known hallmark of carcinogenesis. The microbiota can also affect the response to various treatments including immunotherapy. The microbiome-immune-cancer axis will continue to provide insight into the basic mechanisms of carcinogenesis. In this review, we provide a brief understanding of the mechanisms by which microbiota affects cancer development, progression, and treatment.

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Section: Role Of Microbiota In Cancersupporting

confidence: 54%

Role of Microbiome in Modulating Immune Responses in Cancer

Bose

Mukherjee

2019

Mediators of Inflammation

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“…For example, a prospective cohort study conducted in Sweden showed that Candida infection in the oral cavity was associated with development of PC [55]. Similarly, another population-based cohort study in Taiwan showed that risk of PC was significantly higher among Candida -infected individuals [56]. However, the relationships between fungal infections and PC require further study.…”

Section: Roles Of Microbiomes In Development Of Pcmentioning

confidence: 99%

Role of the microbiome in occurrence, development and treatment of pancreatic cancer

Wang

You

et al. 2019

Mol Cancer

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Pancreatic cancer is one of the most lethal malignancies. Recent studies indicated that development of pancreatic cancer may be intimately connected with the microbiome. In this review, we discuss the mechanisms through which microbiomes affect the development of pancreatic cancer, including inflammation and immunomodulation. Potential therapeutic and diagnostic applications of microbiomes are also discussed. For example, microbiomes may serve as diagnostic markers for pancreatic cancer, and may also play an important role in determining the efficacies of treatments such as chemo-and immunotherapies. Future studies will provide additional insights into the various roles of microbiomes in pancreatic cancer.

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“…Studies have suggested that Candida albicans are associated with number of opportunistic infections in immunocompromised patients like in HIV patients, cancer patients and diabetic patients etc. [3].…”

Section: Introductionmentioning

confidence: 99%

ANTIFUNGAL SUSCEPTIBILITY OF BIOFILM PRODUCING Candida albicans ISOLATED FROM ORAL CAVITY OF DIABETIC AND NON-DIABETIC POPULATION OF DHARAN, NEPAL

Shrestha

Shakya

Khanal

2019

Preprint

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Background: Candida are almost universal on normal adult skin and C. albicans is part of the normal flora of the mucous membranes of the respiratory, gastrointestinal, and female genital tracts. It is acknowledged that diabetic patients are more susceptible to infections caused by Candida albicans due to increased blood glucose and inability of immune system in eradicating the fungus. Studies suggest that Gutkha consumers are also at high risk of oral Candida carriage . Materials and methodology The participants were provided 10 ml of Normal saline and were asked to oral rinse for 1 minute. Oral rinse was collected in a sterile screw capped container and was transported in cold chain to microbiology laboratory. The oral rinse sample was inoculated onto the Sabouraud dextrose agar with Chloramphenicol and was incubated at 37°C for 3-4 days. The Colony forming Unit of candida was compared among diabetic and healthy controls. The candida albicans were identified by Germ tube formation. The Candida albicans isolates were subjected to Biofilm assay, Antifungal susceptibility Test, Haemolysin assay, Haemolysis degree and phospholipase assay. Result: This study reported 31.5% prevalence of oral Candida.The Candida carriage in CFU of diabetic population was statistically significant (p<0.05). The maximum isolates were found to be Biofilm producers. There was significant association between Gutkha consumers with oral Candida carriage. The study suggests that there is higher colonization of Candida in diabetic populations than in healthy population. The result also concludes that frequency of Candida in Oral cavity of Gutkha consumers was also higher (p<0.05). All isolated strains of Candida albicans were tested for antifungal susceptibility testing and 76.19% were found to be Resistant to Fluconazole and 50% were found to be resistant to Amphotericin B. There was statistical significance in Biofilm formation and fluconazole Drug resistance. Conclusion The findings indicated highest colonization of oral Candida in diabetic population and in Gutkha consumers. The greatest numbers of isolated Candida albicans were biofilm producer which showed greater frequency of Fluconazole drug resistance.

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Cancer risk in patients with candidiasis: a nationwide population-based cohort study

Cited by 64 publications

References 28 publications

Role of Microbiome in Modulating Immune Responses in Cancer

Role of Microbiome in Modulating Immune Responses in Cancer

Role of the microbiome in occurrence, development and treatment of pancreatic cancer

ANTIFUNGAL SUSCEPTIBILITY OF BIOFILM PRODUCING Candida albicans ISOLATED FROM ORAL CAVITY OF DIABETIC AND NON-DIABETIC POPULATION OF DHARAN, NEPAL

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