Role of the microbiome in occurrence, development and treatment of pancreatic cancer

Wang, Yicheng; Ye, Gang; You, Lei; Yang, Jinshou; Feng, Mengyu; Qiu, Jiangdong; Zhao, Fangyu; Liu, Yueze; Cao, Zhe; Zheng, Lianfang; Zhang, Taiping; Zhao, Yupei

doi:10.1186/s12943-019-1103-2

Cited by 78 publications

(86 citation statements)

References 173 publications

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“…The oncogenic role of microbial dysbiosis has been acknowledged in pancreatic cancer, especially influential to immune status and contracture. Microbiomes affect the development of pancreatic cancer, including inflammation and immunomodulation via innate and adaptive immunity ( Wang et al, 2019 ; Wei et al, 2019 ). Depletion of the gut microbiome led to a series of alterations in the tumor immune microenvironment, incorporating the diminution of MDSC infiltration and the reorientation toward the M1-like phenotype and promoting the tumoricidal effects of T cells.…”

Section: Tlrs-related Inflammation On Tam Polarizationmentioning

confidence: 99%

Tumor-Associated Macrophages in Pancreatic Ductal Adenocarcinoma: Origin, Polarization, Function, and Reprogramming

Yang

Liu

Liao

2021

Front. Cell Dev. Biol.

133

114

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Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal malignancy. PDAC is only cured by surgical resection in its early stage, but there remains a relatively high possibility of recurrence. The development of PDAC is closely associated with the tumor microenvironment. Tumor-associated macrophages (TAMs) are one of the most abundant immune cell populations in the pancreatic tumor stroma. TAMs are inclined to M2 deviation in the tumor microenvironment, which promotes and supports tumor behaviors, including tumorigenesis, immune escape, metastasis, and chemotherapeutic resistance. Herein, we comprehensively reviewed the latest researches on the origin, polarization, functions, and reprogramming of TAMs in PDAC.

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Section: Tlrs-related Inflammation On Tam Polarizationmentioning

confidence: 99%

Tumor-Associated Macrophages in Pancreatic Ductal Adenocarcinoma: Origin, Polarization, Function, and Reprogramming

Yang

Liu

Liao

2021

Front. Cell Dev. Biol.

133

114

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“…Several risk factors have been associated with PDAC, including tobacco smoking, diabetes mellitus, obesity, dietary factors, alcohol abuse, age, ethnicity, family history and genetic factors, Helicobacter pylori infection, belonging to non-0 blood group, and chronic pancreatitis [6,[10][11][12]. The inflammation and immunosuppression caused by microbiome changes are other factors involved in the development of PDAC, and they are able to affect the metabolism of chemotherapy [13].…”

Section: Introductionmentioning

confidence: 99%

CD36 and CD97 in Pancreatic Cancer versus Other Malignancies

Tănase

Gheorghișan-Gălățeanu

Popescu

et al. 2020

IJMS

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Starting from the recent identification of CD36 and CD97 as a novel marker combination of fibroblast quiescence in lung during fibrosis, we aimed to survey the literature in search for facts about the separate (or concomitant) expression of clusters of differentiation CD36 and CD97 in either tumor- or pancreatic-cancer-associated cells. Here, we provide an account of the current knowledge on the diversity of the cellular functions of CD36 and CD97 and explore their potential (common) contributions to key cellular events in oncogenesis or metastasis development. Emphasis is placed on quiescence as an underexplored mechanism and/or potential target in therapy. Furthermore, we discuss intricate signaling mechanisms and networks involving CD36 and CD97 that may regulate different subpopulations of tumor-associated cells, such as cancer-associated fibroblasts, adipocyte-associated fibroblasts, tumor-associated macrophages, or neutrophils, during aggressive pancreatic cancer. The coexistence of quiescence and activated states in cancer-associated cell subtypes during pancreatic cancer should be better documented, in different histological forms. Remodeling of the local microenvironment may also change the balance between growth and dormant state. Taking advantage of the reported data in different other tissue types, we explore the possibility to induce quiescence (similar to that observed in normal cells), as a therapeutic option to delay the currently observed clinical outcome.

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“…To date, numerous case-control studies, prospective cohort studies, and meta-analyses have suggested that H. pylori infection is associated with an increased risk of PDAC ( 27 – 29 ). However, some studies have found that there is no correlation between the two ( 30 – 32 ). A Swedish study detected H. pylori DNA in pancreatic tumor tissues and/or surrounding tissues in 60% of patients with pancreatic cancer, proposing that H. pylori may play a role in the occurrence of pancreatic cancer ( 33 ).…”

Section: Composition Of Microorganisms Colonized In Pancreatic Cancermentioning

confidence: 99%

“…palmitoleic acid, short-chain fatty acids) reduce inflammation by regulating the production of Foxp3 + T cells or reducing IFN-γ produced by T cells ( 112 ). The microbiome causes changes in human metabolism, leading to metabolic diseases such as obesity and diabetes, which are important factors in the development of PDAC ( 30 ). Geller et al have experimentally demonstrated that pancreatic colonized bacteria are part of the PDAC tumor microenvironment and may play a key role in mediating chemotherapy resistance.…”

Section: Pancreas-related Microbial Metabolism and Pancreatic Cancermentioning

confidence: 99%

Research Progress of Pancreas-Related Microorganisms and Pancreatic Cancer

Zhang

et al. 2021

Front. Oncol.

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Pancreatic cancer is one of the most common digestive system cancers. Early diagnosis is difficult owing to the lack of specific symptoms and reliable biomarkers. The cause of pancreatic cancer remains ambiguous. Smoking, drinking, new-onset diabetes, and chronic pancreatitis have been proven to be associated with the occurrence of pancreatic cancer. In recent years, a large number of studies have clarified that a variety of microorganisms colonized in pancreatic cancer tissues are also closely related to the occurrence and development of pancreatic cancer, and the specific mechanisms include inflammatory induction, immune regulation, metabolism, and microenvironment changes caused by microorganism. The mechanism of action of the pancreatic colonized microbiome in the tumor microenvironment, as well as immunotherapy approaches require further study in order to find more evidence to explain the complex relationship between the pancreatic colonized microbiome and PDAC. Relevant studies targeting the microbiome may provide insight into the mechanisms of PDAC development and progression, improving treatment effectiveness and overall patient prognosis. In this article, we focus on the research relating to the microorganisms colonized in pancreatic cancer tissues, including viruses, bacteria, and fungi. We also highlight the microbial diversity in the occurrence, invasion, metastasis, treatment, and prognosis of pancreatic cancer in order to elucidate its significance in the early diagnosis and new therapeutic treatment of pancreatic cancer, which urgently need to be improved in clinical practice. The elimination or increase in diversity of the pancreatic microbiome is beneficial for prolonging the survival of PDAC patients, improving the response to chemotherapy drugs, and reducing tumor burden. The colonization of microorganisms in the pancreas may become a new hotspot in the diagnosis and treatment of pancreatic cancer.

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Role of the microbiome in occurrence, development and treatment of pancreatic cancer

Cited by 78 publications

References 173 publications

Tumor-Associated Macrophages in Pancreatic Ductal Adenocarcinoma: Origin, Polarization, Function, and Reprogramming

Tumor-Associated Macrophages in Pancreatic Ductal Adenocarcinoma: Origin, Polarization, Function, and Reprogramming

CD36 and CD97 in Pancreatic Cancer versus Other Malignancies

Research Progress of Pancreas-Related Microorganisms and Pancreatic Cancer

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