Cancer risk perception in relation to associated symptoms in Barrett's patients: A cross sectional study on quality of life

Loon, Mirjam C. M. van der Ende-van; Rosmolen, Wilda D.; Houterman, Saskia; Schoon, Erik J.; Curvers, Wouter L.

doi:10.1177/2050640618798508

Cited by 10 publications

(18 citation statements)

References 23 publications

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“…Another factor increasing fear of cancer was the presence of EAC in family or friends. This finding seems consistent with our previous study, in which we found that the presence of cancer in family or friends was associated with overestimating one's own risk of developing EAC [15].…”

Section: Discussionsupporting

confidence: 93%

“…Consistent with the literature [4,[8][9][10]15,18], the present study found that although a minority of patients (discussed more in the DBEp than NDBEp) mentioned that fear of cancer had a daily impact on their quality of life, all patients agreed that experiencing symptoms increased thoughts of developing cancer. Another factor increasing fear of cancer was the presence of EAC in family or friends.…”

Section: Discussionsupporting

confidence: 90%

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Factors influencing health-related quality of life in patients with Barrett’s esophagus: a qualitative focus group study

Loon¹,

Brouwers²,

Munnik

et al. 2021

European Journal of Gastroenterology &Amp; Hepatology

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Introduction Barrett's esophagus is a premalignant condition in the lower part of the esophagus, caused by gastroesophageal reflux disease. Previous studies found that having a Barrett's esophagus is associated with a significant decrease of health-related quality of life (HRQOL). Over the past decade, a considerable amount of literature has been published on the development of endoscopic treatment for (early) neoplasia in Barrett's esophagus. Though, currently very little is known about the impact of those endoscopic treatments on HRQOL from the perspective of patients. In this study, we aim to assess the factors influencing HRQOL according to Barrett's esophagus patients. Methods By using a qualitative focus group design, patients with nondysplastic Barrett's esophagus and patients with a history of endoscopic treatment for Barrett's dysplasia were included. Data were analysed following the conventional content analyses approach. Results A total of 34 patients participated in the four focus group sessions. Experiencing symptoms was valued as the most important factor in both groups. Other factors identified as important HRQOL influencers were: use of medication, fear of cancer and trust in physicians and endoscopic procedures. Conclusions In general, Barrett's esophagus patients experienced a good HRQOL, with a minimal emotional burden from the diagnosis of Barrett's esophagus. Most influencing factor on HRQOL was: experiencing reflux and dyspepsia symptoms. This study underlines the importance of adequate gastroesophageal reflux treatment and providing information to Barrett's esophagus patients, tailored to their personal needs.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 90%

Factors influencing health-related quality of life in patients with Barrett’s esophagus: a qualitative focus group study

Loon¹,

Brouwers²,

Munnik

et al. 2021

European Journal of Gastroenterology &Amp; Hepatology

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“…9 Our recent study, performed in a Dutch single center, showed decreased HRQoL in those patients who overestimated their cancer risk. 6 Most BE patients reported a HRQoL compared to a general Dutch population, this in contrast to the results on HRQoL in previous studies. 10 Many of these studies are underpowered, single center or cannot be reliably compared with current patient pathways.…”

Section: Introductioncontrasting

confidence: 85%

“…5 Previous studies have shown it is difficult for patients to accurately estimate this cancer risk. [6][7][8] These perceptions on developing EAC may affect patients' HRQoL. HRQoL is generally considered encompassing patients' physical-, psychological-, and social functioning, which can be affected by both the disease and treatment.…”

Section: Introductionmentioning

confidence: 99%

Barrett Esophagus: Quality of life and factors associated with illness perception

et al. 2022

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Background Health‐related Quality of life (HRQoL) in patients with Barrett's esophagus (BE), a premalignant condition, may be influenced by gastroesophageal reflux disease (GERD) symptoms and the risk of developing esophageal adenocarcinoma. Methods We aim to investigate HRQoL in non‐dysplastic Barrett Esophagus (NDBE) patients, identify factors associated with a negative illness perception of the diagnosis BE and compare outcomes between patients treated in a specialized BE center with non‐expert centers. In this multi‐center cross‐sectional study, HRQoL of NDBE patients were assessed using the Short Form 36, Hospital Anxiety and Depression Scale, Cancer worry Scale, and Reflux Disease Questionnaire. A multivariable, linear regression analysis was conducted to assess factors associated with illness perception (Illness perception scale) of the BE diagnosis. Outcome parameters of patients from expert centers were compared to non‐expert centers. Results A total of 859 NDBE patients (mean age 63.6% and 74.5% male), of which 640 from BE expert centers were included. BE patients scored similar or higher means (i.e. better) on generic HRQoL in comparison with a Dutch norm population. The multivariable regression model showed that cancer worry, GERD symptoms, signs of anxiety and depression, and female gender were associated with a negative illness perception of BE. GERD symptoms were reported in the minority (22.4%) of BE patients. Levels of anxiety symptoms were comparable to a Dutch norm population (mean 3.7 vs. 3.9 p 0.183) and lower for depression symptoms (mean 6.8 vs. 7.6 p < 0.001). Overall, there were no differences found on outcomes between expert centers and non‐expert centers. Conclusion NDBE patients scored similar or better on generic HRQoL, anxiety and depression than an age and gender matched norm population. The presence of cancer worry, gastrointestinal symptoms, anxiety and depression, and female gender are factors associated with a negative illness perception of the diagnosis BE.

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“…With a reported 30–125-fold relative risk of the lethal esophageal adenocarcinoma (EAC) ( 3 ), the incidence of BE has increased dramatically in the past 40–50 years, despite controlling for increased endoscopy rates ( 4 – 6 ). Patient quality of life suffers significantly because of BE-associated symptoms, which include regurgitation, difficulty swallowing, heartburn, chest pain, and justifiable fear of progression to cancer ( 7 ). Although the risk factors such as male sex, being non-Hispanic White, symptomatic gastroesophageal reflux disease (GERD), smoking, central obesity, physical activity, and alcohol intake for BE have been extensively investigated ( 8 ), the exact cause of BE is still unknown.…”

Section: Introductionmentioning

confidence: 99%

Insights Into the Oral Microbiome and Barrett's Esophagus Early Detection: A Narrative Review

Zhang

Curran

Dindar

et al. 2021

Clin Transl Gastroenterol

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Barrett's esophagus (BE) prevalence has increased steadily over the past several decades and continues to be the only known precursor of esophageal adenocarcinoma. The exact cause of BE is still unknown. Most evidence has linked BE to gastroesophageal reflux disease, which injures squamous esophageal mucosa and can result in the development of columnar epithelium with intestinal metaplasia. However, this relationship is inconsistent—not all patients with severe gastroesophageal reflux disease develop BE. There is increasing evidence that the host microbiome spanning the oral and esophageal environments differs in patients with and without BE. Several studies have documented the oral and esophageal microbiome's composition for BE with inconsistent findings. The scarcity and inconsistency of the literature and the dynamic phenomena of microbiota all warrant further studies to validate the findings and dissect the effects of oral microbiota, which are considered a viable proxy to represent esophageal microbiota by many researchers. This review aims to summarize the variability of the oral and esophageal microbiome in BE by using the example of Streptococcus to discuss the limitations of the current studies and suggest future directions. Further characterization of the sensitivity and specificity of the oral microbiome as a potential risk prediction or prevention marker of BE is critical, which will help develop noninvasive early detection methods for BE, esophageal adenocarcinoma, and other esophageal diseases.

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Cancer risk perception in relation to associated symptoms in Barrett's patients: A cross sectional study on quality of life

Cited by 10 publications

References 23 publications

Factors influencing health-related quality of life in patients with Barrett’s esophagus: a qualitative focus group study

Factors influencing health-related quality of life in patients with Barrett’s esophagus: a qualitative focus group study

Barrett Esophagus: Quality of life and factors associated with illness perception

Insights Into the Oral Microbiome and Barrett's Esophagus Early Detection: A Narrative Review

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