Cancer-specific chemotherapeutic strategy based on the vitamin K3 mediated ROS regenerative feedback and visualized drug release in vivo

Colloidal nanoparticulate technology has been described in the literature as a versatile drug delivery system. But it possesses some inherent lacunae in their formulation. Cyclodextrins (CDs) have been extensively reported for the solubility enhancement of poorly water-soluble drugs. The CDs can cause intervention in aspects related to nanoparticles (NPs) that include improving drug loading in nano-system, improving stability, site-specific/targeted drug delivery, improving solubility profile and absorption of the drug in nanosystem with consequent improvement in bioavailability, with the possibility of controlled release, safety and efficacy. They find application in for simultaneous diagnosis and therapeutics for better treatment procedures. The current communication is focused on the application of CDs to overcome troubles in nanoparticulate formulation and enhancement of their performance. It also envisages the theranostic aspects of CDs.

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“…[143][144][145] Table 4. [149][150][151][152][153][154][155][156][157][158][159][160][161][162][163]…”

Section: An Account Of Recent Advances In Cds For Optimal Drug Deliveryunclassified

Cyclodextrin Based Nanoparticles for Drug Delivery and Theranostics

2020

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“…22,23 Unfortunately, variations in endogenous ROS concentrations because of tumor heterogeneity result in incomplete complete drug release from ROS-sensitive drug delivery systems in vivo. 5,24,25 Therefore, pH/ROS charge-reversal PPDDSs with ROS production capabilities represent a promising alternative strategy to overcome the drawbacks of PPDDSs.…”

Section: Introductionmentioning

confidence: 99%

<p>A pH-Responsive Charge-Reversal Drug Delivery System with Tumor-Specific Drug Release and ROS Generation for Cancer Therapy</p>

Chen

Song

et al. 2020

IJN

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Poor cell uptake and incomplete intracellular drug release are the two major challenges for polymeric prodrug-based drug delivery systems (PPDDSs) in cancer treatment. Methods: Herein, a PPDDS with pH-induced surface charge-reversal and reactive oxygen species (ROS) amplification for ROS-triggered self-accelerating drug release was developed, which was formed by encapsulating a ROS generation agent (vitamin K3 (VK3)) in pH/ROS dual-sensitive polymetric prodrug (PEG-b-P(LL-g-TK-PTX)-(LL-g-DMA)) based micelle nanoparticles (denoted as PVD-NPs). Results: The surface charge of the PVD-NPs can change from negative to positive for enhanced cell uptake in response to tumor extracellular acidity pH. After internalization by cancer cells, PVD-NPs demonstrate dual drug release in response to intracellular ROS-rich conditions. In addition, the released VK3 can produce ROS under the catalysis by NAD(P)H: quinone oxidoreductase-1, which facilitates tumor-specific ROS amplification and drug release selectively in cancer cells to enhance chemotherapy. Conclusion: Both in vitro and in vivo experiments demonstrated that the PVD-NPs showed significant antitumor activity in human prostate cancer.

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“…The zeta potentials of OF ‐2 and CF ‐2 were determined to be 11.43 and 7.00 mV, respectively (Figure S14, Supporting Information); and the positively charged surface of the nanoparticles can be expected to facilitate their entry into cells. [ 19 ] Element mapping analysis of the nanoparticles (Figure S15, Supporting Information) confirmed that they contained Ru, derived from Ru‐HOP‐CD. Generally speaking, visible‐light irradiation of Ru complexes tends to generate reactive oxygen species, [ 20 ] which suggests that these nanoparticles might have biological applications.…”

Section: Methodsmentioning

confidence: 95%

Quaternary Supramolecular Nanoparticles as a Photoerasable Luminescent Ink and Photocontrolled Cell‐Imaging Agent

Chen

Dai

et al. 2020

Advanced Optical Materials

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Photoswitchable luminescent supramolecular assemblies based on cyclodextrins have attracted considerable attention owing to their potential applications as smart materials, but most of the assemblies reported to date emit green or blue light with low contrast and high interference. In this study, novel photoluminescent red‐luminescent quaternary supramolecular nanoparticles (2) are constructed from a dithienylethene derivative (1), a β‐cyclodextrin‐functionalized ruthenium complex (Ru‐HOP‐CD), Pluronic F‐127, and cetrimonium bromide. Compared with the binary assembly 1@Ru‐HOP‐CD, the quaternary nanoparticles exhibit high fluorescence resonance energy transfer efficiency, with Ru‐HOP‐CD acting as the donor and 1 as the acceptor. Owing to the reversible photoswitched interconversion of the two forms of the dithienylethene component, the fluorescence of the nanoparticles could be switched on/off by irradiation with UV or visible light, both in solution and in the solid state. As a result, the nanoparticles could be used as a photoerasable red‐luminescent ink and as a photocontrolled cell‐imaging agent. These functional nanoparticles can be expected to be useful in the fields of information security and biology.

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Cancer-specific chemotherapeutic strategy based on the vitamin K3 mediated ROS regenerative feedback and visualized drug release in vivo

Cited by 43 publications

References 40 publications

Cyclodextrin Based Nanoparticles for Drug Delivery and Theranostics

Cyclodextrin Based Nanoparticles for Drug Delivery and Theranostics

<p>A pH-Responsive Charge-Reversal Drug Delivery System with Tumor-Specific Drug Release and ROS Generation for Cancer Therapy</p>

Quaternary Supramolecular Nanoparticles as a Photoerasable Luminescent Ink and Photocontrolled Cell‐Imaging Agent

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