Cancer stem cell-derived exosome-induced metastatic cancer: An orchestra within the tumor microenvironment

Rashid, Khalid; Ahmad, Aqeel; Meerasa, Semmal Syed; Khan, Abdul Quaiyoom; Wu, Xiaobo; Li, Liang; Cui, Yuehong; Liu, Tianshu

doi:10.1016/j.biochi.2023.03.014

Cited by 10 publications

(3 citation statements)

References 120 publications

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“…Cell seeding is one of the approaches employed in tissue engineering. However, direct cell transplantation entails various risks, including tumorigenicity, ethical concerns, immune rejection, and embolism [ [38] , [39] , [40] ]. Exosomes, as cell-to-cell messengers, facilitate the transport of important functional substances from donor cells to recipient cells and regulate specific functions of target cells through paracrine effects [ 41 ].…”

Section: Discussionmentioning

confidence: 99%

Construction of a novel cell-free tracheal scaffold promoting vascularization for repairing tracheal defects

Shen,

Sun,

Shan

et al. 2023

Materials Today Bio

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Section: Discussionmentioning

confidence: 99%

Construction of a novel cell-free tracheal scaffold promoting vascularization for repairing tracheal defects

Shen,

Sun,

Shan

et al. 2023

Materials Today Bio

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“…These generated small extracellular vesicles may modulate the activity of mesenchymal stromal, cancer-associated fibroblasts and immune. Meanwhile particularly during hypoxic condition, the performance of endothelial cells can be controlled by mesenchymal stromal and tumor ( Rashid et al, 2023 ). The combination of immune, cancer-associated fibroblast and endothelial cells may enhance angiogenesis ( Fu et al, 2020 ).…”

Section: Mirna and Cancer Immune Evasionmentioning

confidence: 99%

Mapping the function of MicroRNAs as a critical regulator of tumor-immune cell communication in breast cancer and potential treatment strategies

Abdul Manap,

Wisham,

Wong

et al. 2024

Front. Cell Dev. Biol.

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Among women, breast cancer ranks as the most prevalent form of cancer, and the presence of metastases significantly reduces prognosis and diminishes overall survival rates. Gaining insights into the biological mechanisms governing the conversion of cancer cells, their subsequent spread to other areas of the body, and the immune system’s monitoring of tumor growth will contribute to the advancement of more efficient and targeted therapies. MicroRNAs (miRNAs) play a critical role in the interaction between tumor cells and immune cells, facilitating tumor cells’ evasion of the immune system and promoting cancer progression. Additionally, miRNAs also influence metastasis formation, including the establishment of metastatic sites and the transformation of tumor cells into migratory phenotypes. Specifically, dysregulated expression of these genes has been associated with abnormal expression of oncogenes and tumor suppressor genes, thereby facilitating tumor development. This study aims to provide a concise overview of the significance and function of miRNAs in breast cancer, focusing on their involvement as tumor suppressors in the antitumor immune response and as oncogenes in metastasis formation. Furthermore, miRNAs hold tremendous potential as targets for gene therapy due to their ability to modulate specific pathways that can either promote or suppress carcinogenesis. This perspective highlights the latest strategies developed for miRNA-based therapies.

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“…Cisplatin resistance is a problem for bladder cancer although bladder cancer is relatively sensitive to chemotherapy. Previous studies have indicated that exosomes can promote chemotherapy resistance [ 101 ]. Consistent with these results, Guangyue Luo found that exosomal LINC00355 derived from CAFs promoted the cisplatin chemoresistance of bladder cancer via the miR-34b-5p/ABCB1 axis [ 102 ].…”

Section: Introductionmentioning

confidence: 99%

Exosome, the glass slipper for Cinderella of cancer—bladder cancer?

Yang,

Miao,

et al. 2023

J Nanobiotechnol

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Exosomes are lipid bilayer vesicles with a diameter of 40–100 nm secreted by almost all cells. They have been found play crucial regulatory roles in various diseases. With the development of exosomes engineering technology, exosome-based drug delivery has also rapidly evolved. Bladder cancer is a worldwide disease with high morbidity and recurrence but lack of funding, so it is also called Cinderella. Some explorations have demonstrated that exosomes are important in the development, prognosis, diagnosis and drug delivery of bladder cancer. With the rapid development of Mass spectrometry and next-generation sequencing, increasing numbers of differentially expressed molecules derived from exosomes have been found in bladder cancer. Exosomes and their contents are largely involved in bladder cancer progression, engineering of these exosomes with the targeted genes improves their potential for drug delivery of bladder cancer. Furthermore, exosomes and their contents are relate to many characteristics of bladder cancer. Herein, we briefly search 59 researches to explore the cargoes encapsuled in exosomes of bladder cancer patients. We also summarize the biogenesis, function, expression profiles, engineering approaches and biological mechanisms of exosomes and their contents for the diagnosis, prognosis and drug delivery for bladder cancer. We aim to make it clear whether exosomes are the glass slippers of Cinderella. Graphical Abstract

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Cancer stem cell-derived exosome-induced metastatic cancer: An orchestra within the tumor microenvironment

Cited by 10 publications

References 120 publications

Construction of a novel cell-free tracheal scaffold promoting vascularization for repairing tracheal defects

Construction of a novel cell-free tracheal scaffold promoting vascularization for repairing tracheal defects

Mapping the function of MicroRNAs as a critical regulator of tumor-immune cell communication in breast cancer and potential treatment strategies

Exosome, the glass slipper for Cinderella of cancer—bladder cancer?

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