Cancer Stem Cells—The Insight into Non-Coding RNAs

Bryl, Rut; Piwocka, Oliwia; Kawka, Emilia; Mozdziak, Paul; Kempisty, Bartosz; Knopik-Skrocka, Agnieszka

doi:10.3390/cells11223699

Cited by 3 publications

(1 citation statement)

References 185 publications

(219 reference statements)

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“…M2 macrophage-derived exosomes transfer various biomolecules, including growth factors, cytokines, miRNAs, long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs) (Table I) have been shown to promote self-renewal and survival of CSCs (58). They can also modulate the signaling pathways and molecular processes that regulate CSCs, thereby maintaining and expanding the cancer stem cell population (58).…”

Section: M2 Macrophage-derived Exosomes In Cancer Cell Stemnessmentioning

confidence: 99%

Key role of exosomes derived from M2 macrophages in maintaining cancer cell stemness (Review)

Zhang,

Zhou,

Liu

et al. 2023

Int J Oncol

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Cancer stem cells (CSCs) constitute a specific subset of cells found within tumors that are responsible for initiating, advancing and resisting traditional cancer treatments. M2 macrophages, also known as alternatively activated macrophages, contribute to the development and progression of cancer through their involvement in promoting angiogenesis, suppressing the immune system, supporting tumor growth and facilitating metastasis. Exosomes, tiny vesicles released by cells, play a crucial role in intercellular communications and have been shown to be associated with cancer development and progression by influencing the immune response; thus, they may serve as markers for diagnosis and prognosis. Currently, investigating the impact of exosomes derived from M2 macrophages on the maintenance of CSCs is a crucial area of research with the aim of developing novel therapeutic strategies to target this process and improve outcomes for individuals with cancer. Understanding the biological functions of exosomes derived from M2 macrophages and their involvement in cancer may lead to the formulation of novel diagnostic tools and treatments for this disease. By targeting M2 macrophages and the exosomes they secrete, promising prospects emerge for cancer treatment, given their substantial contribution to cancer development and progression. Further research is required to fully grasp the intricate interactions between CSCs, M2 macrophages and exosomes in cancer, and to identify fresh targets for cancer therapy. The present review explores the pivotal roles played by exosomes derived from M2 cells in maintaining the stem-like properties of cancer cells. Contents1. Introduction 2. CSCs in tumor progression 3. Role of M2 macrophages in tumor progression 4. Characteristics and composition of macrophage-derived exosomes 5. M2 macrophage-derived exosomes in cancer cell stemness 6. Therapeutic agents targeting M2 macrophages for cancer treatment in clinical trials 7. Possible therapeutic approaches involving exosomes derived from macrophages in cancer treatment 8. Conclusions and future perspectives

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Section: M2 Macrophage-derived Exosomes In Cancer Cell Stemnessmentioning

confidence: 99%

Key role of exosomes derived from M2 macrophages in maintaining cancer cell stemness (Review)

Zhang,

Zhou,

Liu

et al. 2023

Int J Oncol

View full text Add to dashboard Cite

show abstract

Genetic and epigenetic regulation of non-coding RNAs: Implications in cancer metastasis, stemness and drug resistance

Dakal,

Philip,

Bhushan

et al. 2025

Pathology - Research and Practice

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The emerging role of oral microbiota in oral cancer initiation, progression and stemness

Saikia,

Pathak,

Mitra

et al. 2023

Front. Immunol.

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Oral squamous cell carcinoma (OSCC) is the most prevalent malignancy among the Head and Neck cancer. OSCCs are highly inflammatory, immune-suppressive, and aggressive tumors. Recent sequencing based studies demonstrated the involvement of different oral microbiota in oral cavity diseases leading OSCC carcinogenesis, initiation and progression. Researches showed that oral microbiota can activate different inflammatory pathways and cancer stem cells (CSCs) associated stemness pathways for tumor progression. We speculate that CSCs and their niche cells may interact with the microbiotas to promote tumor progression and stemness. Certain oral microbiotas are reported to be involved in dysbiosis, pre-cancerous lesions, and OSCC development. Identification of these specific microbiota including Human papillomavirus (HPV), Porphyromonas gingivalis (PG), and Fusobacterium nucleatum (FN) provides us with a new opportunity to study the bacteria/stem cell, as well as bacteria/OSCC cells interaction that promote OSCC initiation, progression and stemness. Importantly, these evidences enabled us to develop in-vitro and in-vivo models to study microbiota interaction with stem cell niche defense as well as CSC niche defense. Thus in this review, the role of oral microbiota in OSCC has been explored with a special focus on how oral microbiota induces OSCC initiation and stemness by modulating the oral mucosal stem cell and CSC niche defense.

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Cancer Stem Cells—The Insight into Non-Coding RNAs

Cited by 3 publications

References 185 publications

Key role of exosomes derived from M2 macrophages in maintaining cancer cell stemness (Review)

Key role of exosomes derived from M2 macrophages in maintaining cancer cell stemness (Review)

Genetic and epigenetic regulation of non-coding RNAs: Implications in cancer metastasis, stemness and drug resistance

The emerging role of oral microbiota in oral cancer initiation, progression and stemness

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