Objective:To analyze the specific five-year survival of colorectal cancer (CRC) diagnosed between 2008 and 2013, according to sex and age group, of residents in Greater Cuiabá, state of Mato Grosso, Brazil. Methods: This is a retrospective cohort study. Specific survival of CRC was considered as the time between disease diagnosis and death from CRC, in months. Data from the Population-Based Cancer Registry and the Brazilian Mortality Information System were used. To estimate the probability of survival by sex and age group, the Kaplan-Meier estimator was used, and to estimate the effect of age group on the survival of participants, the Cox model stratified by sex was adjusted. Results: From 2008 to 2013, 683 new cases and 193 deaths from CRC were registered. The median time between diagnosis and death from CRC was 44.8 months for men, and the five-year survival probabilities of 83.5% (95%CI 79.9-87.2%) and 89.6% (95%CI 86.4-93.0%), respectively. Men aged 70-79 years (HR=2.97; 95%CI 1.11-3.87) and 80 years or older (HR=3.09; 95%CI 1.31-7.27) were at higher risk of mortality, and we verified no difference for women. Conclusion: Women had a shorter time between the diagnosis of CRC and death from the disease as well as a lower probability of survival. Conversely, men were at higher risk of mortality after 70 years of age.