Cancer survival in Qidong between 1972 and 2011: A population-based analysis

Abstract

Abstract. Population-based cancer survival is an improved index for evaluating the overall efficiency of cancer health services in a given region. The current study analysed the observed survival and relative survival of leading cancer sites from a population-based cancer registry between 1972 and 2011 in Qidong, China. A total of 92,780 incident cases with cancer were registered and followed-up for survival status. The main sites of the cancer types, based on the rank order of incidence, were the liver, stomach, lung, colon and rectum, oesophagus, breast, pancreas, leukaemia, brain and central nervous system (B and CNS), bladder, blood [non-Hodgkin's lymphoma (NHL)] and cervix. For all malignancies combined, the 5-year observed survival was 13.18% and the relative survival was 15.80%. Females had higher observed survival and relative survival (19.32 and 22.71%, respectively) compared with males (9.63 and 11.68%, respectively). The cancer sites with the highest five-year relative survival rates were the female breast, bladder, cervix and colon and rectum; followed by NHL, stomach, B and CNS cancer and leukaemia. The poorest survival rates were cancers of oesophagus, lung, pancreas and liver. Higher survival rates were observed in younger patients compared with older patients. Cancers of the oesophagus, female breast and bladder were associated with higher survival in middle-aged groups. Improved survival rates in the most recent two 5-year calendar periods were identified for stomach, lung, colon and rectum, oesophagus, female breast and bladder cancer, as well as leukaemia and NHL. The observations of the current study provide the opportunity for evaluation of the survival outcomes of frequent cancer sites that reflects the changes and improvement in a rural area in China.

Evaluation of the NMP22 BladderChek test for detecting bladder cancer: a systematic review and meta-analysis

“…Moreover, the subgroup analysis showed that, compared with the Caucasian populations, the test had better ability to detect bladder cancer in Asian populations. Considering the increasing incidence of bladder cancer in Asian countries, the NMP22 BladderChek test should be promoted for bladder cancer detection and follow-up [ 41 ].…”

HIF-1α promotes hepatocellular carcinoma metastasis by regulating angiogenesis and epithelial-mesenchymal transition

“…Hepatocellular carcinoma (HCC) is one of the most commonly diagnosed and deadly malignant tumors worldwide [1] . HCC was still one of the most cancers in the inshore area of Yangtze River, China, due to hepatitis B virus (HBV) infection-related chronic hepatitis or liver cirrhosis [2] . There have been no more effective therapeutic options in the advanced HCC beyond sorafenib or a multi-targeted tyrosine kinase inhibitors, because hepatic hypoxia enhances cell proliferation, angiogenesis, and suppresses differentiation and apoptosis leads to resistance of transarterial chemoembolization (TACE) [3,4] .…”

Oncogenic Wnt3a: a promising specific biomarker in hepatocellular carcinoma

“…Hepatocellular carcinoma (HCC) is one of the most common or deathly human malignancy cancers worldwide [1,2] , especially in the areas along the Yangtze River. Recently, Chen et al [3] reported the observed survival and relative survival of leading cancer sites from a population-based cancer registry for 40 years. The main sites of the cancer types with a total of 92,780 incident cases in Qidong, China, HCC ranks the first based on the rank order of incidence among all malignancies (liver, stomach, lung, colon and rectum, oesophagus, breast, pancreas, leukaemia, brain and central nervous system, bladder, non-Hodgkin's lymphoma, and cervix) and the poorest survival rate [3] .…”

“…Recently, Chen et al [3] reported the observed survival and relative survival of leading cancer sites from a population-based cancer registry for 40 years. The main sites of the cancer types with a total of 92,780 incident cases in Qidong, China, HCC ranks the first based on the rank order of incidence among all malignancies (liver, stomach, lung, colon and rectum, oesophagus, breast, pancreas, leukaemia, brain and central nervous system, bladder, non-Hodgkin's lymphoma, and cervix) and the poorest survival rate [3] . The leading etiological factors of HCC include chronic hepatitis B or C virus (HBV [4][5][6] or HCV [7,8] ) infection, aflatoxin contaminated food taken and non-alcohol fat liver diseases (NAFLD) [9,10] .…”