Cancer Theranostics With Hollow Gold Nanospheres

Key Factors Affecting the Reproducibility of Synthesis and Growth Mechanism of Near-Infrared Absorbing Hollow Gold Nanospheres

“…Noble metal nanoparticles are of great interest for the therapeutic treatment of cancer via photothermal ablation (PTA) therapy due to their small size and strong optical absorption. − In PTA, metal nanoparticles attached to cancerous cells are resonantly illuminated by light causing rapid particle heating, modifying the local cellular temperature significantly, and inducing cell death. − Both cellular uptake and photothermal conversion are dependent on nanoparticle size and shape, with spherical nanostructures demonstrating the best performance to date. − To generate highly efficient PTA candidate structures, it is important to take into account surface plasmon resonance (SPR) wavelength, which is largely determined by particle shape and, to a lesser degree, size . Particle size and shape also determine biological interaction and, therefore, place a limitation on the type of structures that can be used. − ,− …”