Cancers de la cavité buccale : à propos de 145 cas à l’institut Joliot-Curie de Dakar

Dieng, Mamadou Moustapha; Dem, Ahmadou; Gaye, Papa Macoumba; Diouf, Doudou; Toure, S.; Diop, Rudolph; Ndiaye, M.; Loum, B.

doi:10.1016/j.canrad.2012.07.090

Cited by 4 publications

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“…Moderate alcohol intake (10 to 19 g / day) has little or no effect on the risk of VADS cancer in a non-smoker [5].…”

Section: Discussionmentioning

confidence: 98%

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Cancers of Oral Cavity Epidemiological and Clinical Study About 70 Cases

Allaye¹,

Faissal²,

Koussay³

et al. 2019

IJCOMS

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Our retrospective study is about 70 cases of cancers of the Oral cavity, collected at the department of maxillo-facial surgery in Mohamed VI hospital university of Marrakech, during 9 years (January 2007-January2016). The mean age has been 60 years (20-94 years old). The women predominate with a ratio, which equal 0.94. Among the etiologic factors, tobacco is 31% of our cases and alcohol 6% of our case _Clinically, the mean delay of consultation has been 8 months_the clinical symptomatology has often consisted in the oral cavity lesions (80%), pain has been the second symptom (33%), the difficulty in swallowing and the difficulty in chewing (18%) and clinical examination showed a ulcero budding tumor in 38% of the cases, the cervical adenopathies have been noticed in 47% of the cases. The definitive diagnosis has been based on the histologic analysis that showed an epidermoid carcinoma in 87% of the cases. According to the TNM classification, the T3 are noticed in 46% and the No is found in 54%. The therapeutic strategy consisted in the surgery alone (58%), the surgery with radiotherapy (33%), the radiotherapy just (9%). Among our patients, we noticed a local recidivism in 3 cases, and we noticedtwo cases of metastasis, 35 patients (50%) are still a live with good carcinologic and functional result, 10 patients died; the other patients have been lost to follow-up.

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“…Moderate alcohol intake (10 to 19 g / day) has little or no effect on the risk of VADS cancer in a non-smoker [5].…”

Section: Discussionmentioning

confidence: 98%

“…Oral cavity cancer is the 15th most common cancer worldwide, with more than 300,000 new cases diagnosed in 2012 (2% of all cancers). [5] In France, [6][7][8] the number of new cases of cancers of the upper aerodigestive tract in 2000 is estimated at 19,600.…”

Section: Discussionmentioning

confidence: 99%

Cancers of Oral Cavity Epidemiological and Clinical Study About 70 Cases

Allaye¹,

Faissal²,

Koussay³

et al. 2019

IJCOMS

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Epidemiological study of oral cavity cancer in private oncology centers of Rabat

2015

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Genetic Alterations of C-MYC Proto-Oncogene and Their Involvement in the Occurrence and Progression of Oral Cavity Cancers in Senegal

Ba,

Mbaye,

Diatta

et al. 2023

J. Mol. Clin. Med.

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Background: Oral cancer is the 17th most common cancer worldwide, with a mortality rate of 1.8%. Their incidence varies considerably, with a clear prevalence in South Asian countries. In Africa, the mortality rate for cancers of the oral cavity is 1.3%. Senegal is a perfect illustration a perfect illustration of the seriousness and scale of this disease, with 177 new cases recorded in 2020, for a mortality rate of 1.4%. To add to the knowledge of the molecular mechanisms involved in the carcinogenesis of these pathologies in Senegal, mutations in the C-MYC proto-oncogene were examined in 22 patients with oral cavity cancers and compared with samples from 32 control individuals. Methods: Cancerous tissue (CT) and adjacent normal tissue (ANT) were sampled from diseased individuals, whereas whole blood was obtained from control individuals (C). A total of 67 samples were collected: 32 from controls, 22 from CTs, and 13 from ANTs of diseased individuals. Total DNA was extracted and polymerase chain reaction (PCR) amplification of exon 2 of the C-MYC gene was performed, followed by Sanger sequencing. Mutation analysis was performed using Mutation Surveyor Software v5.0.1. The effect of each non-synonymous mutation on the function of the encoded protein was determined using the POLYPHEN-2, PANTHER-PSEP, and PROVEAN algorithms. The probability of non-synonymous mutations causing diseases was predicted using Prediction of human Deleterious Single Nucleotide Polymorphism (PhD-SNP) and Predicting disease associated variations using GO terms (SNP&GO). The impact of non-synonymous variations on the stability of the encoded protein was determined using I-Mutant2 and In-silico analysis of Protein Stability (INPS). Results: Of the study participants, 63% were females. The mean age of patients was 46.43 ± 13 years, with extremes of 14 and 83 years and the age range of 40–70 years as the most representative age group. Only 5% of patients were alcohol drinkers and 15% were smokers. Most patients (80%) had stage III or IV tumors with lymph node invasion. A low polymorphism rate in exon 2 of the C-MYC proto-oncogene was identified, with one synonymous substitution (Q48Q) found in a diseased individual (CT and ANT). The non-synonymous substitutions (D31N, D31E, V33G, Y36N, and Y36D) found in the controls were predicted to be damaging and pathogenic, and might decrease the stability of the encoded protein. Conclusions: Our results indicate that the C-MYC protooncogene is not involved in the occurrence and progression of oral cavity cancers in Senegalese patients. However, the mutations found in controls could provide new markers for the early clinical diagnosis of oral cancer.

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Cancers de la cavité buccale : à propos de 145 cas à l’institut Joliot-Curie de Dakar

Cited by 4 publications

References 0 publications

Cancers of Oral Cavity Epidemiological and Clinical Study About 70 Cases

Cancers of Oral Cavity Epidemiological and Clinical Study About 70 Cases

Epidemiological study of oral cavity cancer in private oncology centers of Rabat

Genetic Alterations of C-MYC Proto-Oncogene and Their Involvement in the Occurrence and Progression of Oral Cavity Cancers in Senegal

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