Candicandiol, a new diterpene from “Sideritis candicans” Ait., var. “Eriocephala” webb. (Labiatae)

Studies on the analgesic and anti-inflammatory effects of Sideritis candicans Ait. var. eriocephala Webb aerial part

“…The phytochemical analysis revealed the presence of waxes, squalene and dehidroabietane in the sub-fraction F1, the presence of ␤-sitosterol, campesterol, stigmasterol, glutinol and candol B in sub-fraction F2, the presence of 7␤-monoacetate trachinodiol, 7␤-monoacetate epicandicandiol, ursolic acid and oleanolic acids in the sub-fraction F3, and the presence of candicandiol, candidiol and epicandicandiol in the sub-fraction F4 as their main constituents. The data obtained agreed with those reported in the literature (Bretón et al, 1969;Rodríguez González et al, 1970;González et al, 1973González et al, , 1979Hernández Santana, 1995).…”

“…eriocephala Webb (= Sideritis oroteneriffae L. Negrín et P. Pérez) is an endemic species of the Canary Islands (Darias et al, 1986(Darias et al, , 1989Pérez de Paz and Hernández-Padrón, 1999). Phytochemical studies carried out with this plant revealed that ent-kaurene type diterpenoids, alpha and beta amyrin triterpenic derivatives and steroids were the main components of the aerial parts (Bretón et al, 1969;Rodríguez González et al, 1970;González et al, 1973González et al, , 1979Hernández Santana, 1995). Although some of these compounds are known to exhibit interesting biological actions, including anti-nociceptive and anti-inflammatory properties (Safayhi and Sailer, 1997;García et al, 1999;Calixto et al, 2000;Fernández et al, 2001) and several studies on the analgesic and anti-inflammatory activities of Sideritis species have been published (Jiménez et al, 1986;Alcaráz et al, 1989;Navarro et al, 1997;Aboutabl et al, 2002;Hernández-Pérez and Rabanal Gallego, 2002a,b), no reports have been found concerning the pharmacological action of Sideritis candicans Ait.…”

“…In the Canary Islands, several endemic species of this genus are used in popular medicine as descongestan of the respiratory tract, analgesic, anti-inflammatory, wound healing and astringent agents (Darias et al, 1986(Darias et al, , 1989Pérez de Paz and Hernández-Padrón, 1999). Various researchers have reported different constituents (Bretón et al, 1969;Rodríguez González et al, 1970;González et al, 1973González et al, , 1979, however, very few of their pharmacological effects have been reported (Darias et al, 1990;Hernández-Pérez and Rabanal Gallego, 2002a,b).…”

Biotransformation of the Diterpenes Epicandicandiol and Candicandiol by Mucor plumbeus

“…Compounds 1 and 2 had been obtained from Sideritis candicans , and other species of this genus . We have assigned the 1 H and 13 C NMR spectra of these substrates utilizing 2D NMR data (COSY, HSQC, and HMBC).…”

Natural Products Isolated from Plants of the Canary Islands

“…eriocephala Webb. : From the aerial part the new diterpenes candicandiol 43 as major component and epicandicandiol 44 and candidiol 45 as minor ones have been isolated (Breton et al 196ge;Rodriguez et al 1970g;Piozzi et al 197If). , not yet determined variety: On the basis of the chemical results obtained we suppose that this variety differs from var.…”