Candida albicans enhances invasion of human gingival epithelial cells and gingival fibroblasts by Porphyromonas gingivalis

Tamai, Riyoko; Sugamata, Miho; Kiyoura, Yusuke

doi:10.1016/j.micpath.2011.06.009

Cited by 69 publications

(52 citation statements)

References 52 publications

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“…Further studies have shown that enhanced invasion of a gingival epithelial cell line and gingival fibroblasts by P. gingivalis is enhanced by pre-incubation with heat-killed cells and the mannoprotein-β-glucan complex from C. albicans [42]. The mechanism by which C. albicans facilitates this invasion is unclear, though the authors hypothesise that the recruitment of C. albicans cell wall components increases the recruitment of clathrin in epithelial cells.…”

Section: Periodontal Disease: An Uncontrolled Ganglandmentioning

confidence: 99%

Fungi at the Scene of the Crime: Innocent Bystanders or Accomplices in Oral Infections?

Delaney

Kean

Short

et al. 2018

Curr Clin Micro Rpt

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Purpose of Review Over the last decade, microbiome studies have enhanced our knowledge and understanding of the polymicrobial nature of oral infections. Recently, profiling of the fungal microbiome has expanded our conventional understanding of oral ecology, revealing the critical importance of yeasts within this complex microbiome. This review aims to explore our current appreciation of interkingdom interactions in oral disease. Recent Findings There is a growing evidence base of interactions and pathogenic synergy and antagonism with bacterial species within oral disease. Recent studies have helped to develop our knowledge of how Candida albicans, alongside bacteria such as Porphyromonas gingivalis, Streptococcus mutans, Staphylococcus aureus, Enterococcus faecalis, and Lactobacillus species, influence overall pathogenicity. Summary Clinical and experimental evidence makes a compelling case for a role for C. albicans in a number of oral infections, though whether its role is an active accomplice or passive bystander remains to be determined.

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Section: Periodontal Disease: An Uncontrolled Ganglandmentioning

confidence: 99%

Fungi at the Scene of the Crime: Innocent Bystanders or Accomplices in Oral Infections?

Delaney

Kean

Short

et al. 2018

Curr Clin Micro Rpt

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“…Dectin-1 is expressed on macrophages, monocytes, B-cells, and dendritic cells 42-44, 46-48 . In addition, it is expressed on gingival fibroblasts and may serve some role in the response to oral candidiasis 49 . In light of these observations, we evaluated Dectin-1 expression on human external vulvar (from the perineum) and vestibular fibroblasts and its role in the production of pro-inflammatory mediators in response to challenge with zymosan or live yeast.…”

Section: Introductionmentioning

confidence: 99%

Identification of novel mechanisms involved in generating localized vulvodynia pain

Falsetta

Foster

Woeller

et al. 2015

American Journal of Obstetrics and Gynecology

102

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Objective Our goal was to gain a better understanding of the inflammatory pathways affected during localized vulvodynia, a poorly understood, common, and debilitating condition characterized by chronic pain of the vulvar vestibule. Methods In a control matched study, primary human fibroblast strains were generated from biopsies collected from localized provoked vulvodynia (LPV) cases and age and race-matched controls. We then examined intracellular mechanisms by which these fibroblasts recognize pathogenic Candida albicans; >70% of vulvodynia patients report the occurrence of prior chronic Candida infections, which is accompanied by localized inflammation and elevated production of pro-inflammatory/pain-associated interleukin 6 (IL-6) and prostaglandin E2 (PGE2). We focused on examining the signaling pathways involved in recognition of yeast components that are present and abundant during chronic infection. Results Dectin-1, a surface receptor that binds C. albicans cell wall glucan, was significantly elevated in vestibular versus external vulvar cells (from areas without pain) in both cases and controls, while its abundance was highest in LPV cases. Blocking Dectin-1 signaling significantly reduced pain-associated IL-6 and PGE2 production during the response to C. albicans. Furthermore, LPV patient vestibular cells produced inflammatory mediators in response to low numbers of C. albicans cells, while external vulvar fibroblasts were nonresponsive. Inhibition of NFκB (pro-inflammatory transcription factor) nearly abrogated IL-6 and PGE2 production induced by C. albicans, in keeping with observations that Dectin-1 signals through the NFκB pathway. Conclusion These findings implicate that a fibroblast-mediated pro-inflammatory response to C. albicans contributes to the induction of pain in LPV cases. Targeting this response may be an ideal strategy for the development of new vulvodynia therapies.

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“…49 Ó 2015 Published by Elsevier Ltd. on behalf of Acta Materialia Inc. 50 51 52 53 1. Introduction 54 Nature has provided scientists through the process of evolution 55 with a diverse range of micro/nanostructures which are a poten- 56 tially rich blueprint for new technologies and materials [1][2][3][4][5]. 57 These 'free' architectural adaptations are of particular interest in 58 relation to surfaces as control of interfacial properties is a key 59 aspect in many current and emerging industries.…”

mentioning

confidence: 99%

“…Periodontal disease affects a sig-933 nificant percentage of the population (e.g., around one-half of the 934 US population over 30 years of age) [54]. The bacteria can also 935 invade human epithelial and endothelial cells and enter the gingi-936 val tissue [55]. In addition, P. gingivalis has been linked to rheuma-937 toid arthritis [56].…”

mentioning

confidence: 99%

A gecko skin micro/nano structure – A low adhesion, superhydrophobic, anti-wetting, self-cleaning, biocompatible, antibacterial surface

et al. 2015

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Candida albicans enhances invasion of human gingival epithelial cells and gingival fibroblasts by Porphyromonas gingivalis

Cited by 69 publications

References 52 publications

Fungi at the Scene of the Crime: Innocent Bystanders or Accomplices in Oral Infections?

Fungi at the Scene of the Crime: Innocent Bystanders or Accomplices in Oral Infections?

Identification of novel mechanisms involved in generating localized vulvodynia pain

A gecko skin micro/nano structure – A low adhesion, superhydrophobic, anti-wetting, self-cleaning, biocompatible, antibacterial surface

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