Candida albicans osteomyelitis of the spine: progressive clinical and radiological features and surgical management in three cases

Khazim, Rabi; Debnath, Ujjwal K.; Fares, Youssef

doi:10.1007/s00586-005-0038-z

Cited by 44 publications

(35 citation statements)

References 23 publications

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“…The only 32% to 43% of patients presented with fever at admission and about 20% of patients complained of the neurological deficits 7,8) . Laboratory results frequently revealed elevated ESR and CRP, but a normal WBC count, in accordance with our case 5,7) . Although plain radiograph frequently reveals erosive and destructive changes of the vertebral body, MR imaging is the diagnostic tool of choice for Candida spondylodiscitis 10,14) .…”

Section: Discussionsupporting

confidence: 69%

See 1 more Smart Citation

Cervical Spondylodiscitis Caused by Candida Albicans in Non-Immunocompromised Patient

Moon

Kim

Moon

et al. 2008

J Korean Neurosurg Soc

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Section: Discussionsupporting

confidence: 69%

“…Moreover the involvement of cervical spine is even rarer condition 2,5,9,12) . We present a case of cervical spondylodiscitis in non-immunocompromised patient and discuss treatment option with a review of the literatures.…”

Section: Introductionmentioning

confidence: 99%

Cervical Spondylodiscitis Caused by Candida Albicans in Non-Immunocompromised Patient

Moon

Kim

Moon

et al. 2008

J Korean Neurosurg Soc

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“…11 Stratov et al 12 have shown that combined treatment is also preferable to isolated pharmacotherapy or surgery for many FVO patients. Furthermore, the follow-up mortality rate in this study and throughout the literature is very low (Table 5), and there was no operative mortality in this study.…”

Section: Discussionmentioning

confidence: 99%

Untitled

2011

JHN Journal

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IntroductionFungal vertebral osteomyelitis (FVO) is an uncommon but aggressive disease that may cause spinal instability, neurological insult, and possibly death. Little data about treatment strategies and patient outcomes exist. A retrospective review of medical and surgical management with follow-up of this disease was performed. MethodsA retrospective review was conducted of patients with FVO treated with surgery and pharmacotherapy at a single institution over a 7-year period (1999 to 2006). Patients were included in analysis if they had biopsy and radiographically confirmed vertebral fungal infection. Analysis was constructed through office and medical records. Specific data points included age, gender, microbiology, treatment, clinical presentations and outcomes. ResultsNine patients with FVO were identified (5 females and 4 males) ranging in age from 42 to 77 years (mean=57 years). Advanced age (n=4) and previous spine surgery (n=4) were the most commonly identified risk factors for FVO. Candida species (n=7), Aspergillus fumigatus (n=2), and Saccharomyces cerevisiae (n=1) pathogens were identified. The average pre-operative erythrocyte sedimentation rate (ESR) was 83.2 mm/hr (normal range is 0 to 20 mm/hr) and C-reactive protein (CRP) was 6.9 mg/dL (normal range is 0 to 1.2 mg/dL). Surgical debridement and stabilization procedures were performed in all 9 patients. The average antifungal prescription duration was 21 weeks. Revision surgical procedures (n=5) were the most commonly identified treatment complication, and the average duration between the initial surgery and the first subsequent procedure was 3.5 months (range, 3 weeks to 9 months). In comparison to pre-operative ASIA Impairment Scores, patient neurological status was improved (n=4) or stable (n=3) at latest follow-up. Average follow-up duration was 19 months. There was no mortality. ConclusionsAggressive surgical treatment with concurrent pharmacotherapy can successfully treat FVO and prevent neurological injury. Repeat surgeries are common in patients with progressive vertebral degeneration or persistent infection.

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“…In the same issue of the Journal, there is an interesting report by Khazim et al [14] of three cases of fungal osteomyelitis (Candida albicans) of the spine, with an extensive review of the literature. C. albicans is a rare cause of vertebral osteomyelitis.…”

Section: Infectionmentioning

confidence: 99%

A survey of the “medical” articles in the European Spine Journal, 2006

Benoist¹

2007

Eur Spine J

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Candida albicans osteomyelitis of the spine: progressive clinical and radiological features and surgical management in three cases

Cited by 44 publications

References 23 publications

Cervical Spondylodiscitis Caused by Candida Albicans in Non-Immunocompromised Patient

Cervical Spondylodiscitis Caused by Candida Albicans in Non-Immunocompromised Patient

Untitled

A survey of the “medical” articles in the European Spine Journal, 2006

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