Candida: an unexpected cause of the acute abdomen

Thrumurthy, Sri G.; Tiew, Stephenie; Wood, Nicholas L.; Bhowmick, Arnab

doi:10.1136/bcr.04.2010.2948

Cited by 4 publications

(1 citation statement)

References 10 publications

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“…While VVC is non-lethal, the morbidity associated with VVC brings tremendous mental distress, causing pain, low self-esteem, anxiety, and even impacting affective relations and career [5]. Moreover, VVC has been reported to cause adverse conditions such as cervicitis [6], pelvic inflammatory disease [7], genital tract malignancy [8], infertility [9], fetal intrauterine infection [10], HPV [11], and preterm birth [12].…”

Section: Vulvovaginal Candidiasis (Vvc) Is An Exceedingly Common Infe...mentioning

confidence: 99%

Vaginal homeostasis features of Vulvovaginal Candidiasis through vaginal metabolic profiling

Qiu

Chen

Wang

et al. 2023

Preprint

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Vulvovaginal candidiasis (VVC) is an inflammatory disease primarily caused by candidiasis albicans infection. Metabolomics has been applied to research a variety of inflammatory diseases. In the present study, the vaginal metabolic profiles of VVC patients and healthy populations were explored by a non-targeted metabolomics approach. In total, 211 differential metabolites were identified, with the VVC group having 128 over-expressed and 83 under-expressed metabolites compared with healthy individuals. Functional analysis showed that these metabolites were mainly involved in amino acid metabolism and lipid metabolism. In addition, network software analysis indicated that the differential metabolites were associated with MAPK signaling and NF-κB signaling. Further molecular docking suggested that linoleic acid can bind to the ACSL1 protein, which has been shown to be associated with multiple inflammatory diseases and is an upstream regulator of the MAPK and NF-κB signaling pathways that mediate inflammation. Therefore, our preliminary analysis results suggest that VVC has a unique metabolic profile. Linoleic acid, a significantly elevated unsaturated fatty acid in the VVC group, may promote VVC development through the ACSL1/MAPK and ACSL1/NF-κB signaling pathways. This study’s findings contribute to further exploring the mechanism of VVC infection and providing new perspectives for the treatment of Candida albicans vaginal infection.

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Section: Vulvovaginal Candidiasis (Vvc) Is An Exceedingly Common Infe...mentioning

confidence: 99%

Vaginal homeostasis features of Vulvovaginal Candidiasis through vaginal metabolic profiling

Qiu

Chen

Wang

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

The Role of 17β-Estrogen in Candida albicans Adhesion on Human Vaginal Epithelial Cells via FAK Phosphorylation

et al. 2020

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Vaginal homeostasis features of Vulvovaginal Candidiasis through vaginal metabolic profiling

et al. 2023

View full text Add to dashboard Cite

Vulvovaginal candidiasis (VVC) is an inflammatory disease primarily infected by Candida albicans. The condition has good short-term treatment effects, high recurrence, and seriously affects the quality of life of women. Metabolomics has been applied to research a variety of inflammatory diseases. In the present study, the vaginal metabolic profiles of VVC patients and healthy populations (CTL) were explored by a non-targeted metabolomics approach. In total, 211 differential metabolites were identified, with the VVC group having 128 over-expressed and 83 under-expressed metabolites compared with healthy individuals. Functional analysis showed that these metabolites were mainly involved in amino acid metabolism and lipid metabolism. In addition, network software analysis indicated that the differential metabolites were associated with MAPK signaling and NF-κB signaling. Further molecular docking suggested that linoleic acid can bind to the ACSL1 protein, which has been shown to be associated with multiple inflammatory diseases and is an upstream regulator of the MAPK and NF-κB signaling pathways that mediate inflammation. Therefore, our preliminary analysis results suggest that VVC has a unique metabolic profile. Linoleic acid, a significantly elevated unsaturated fatty acid in the VVC group, may promote VVC development through the ACSL1/MAPK and ACSL1/NF-κB signaling pathways. This study's findings contribute to further exploring the mechanism of VVC infection and providing new perspectives for the treatment of Candida albicans vaginal infection.

show abstract

Candida: an unexpected cause of the acute abdomen

Cited by 4 publications

References 10 publications

Vaginal homeostasis features of Vulvovaginal Candidiasis through vaginal metabolic profiling

Vaginal homeostasis features of Vulvovaginal Candidiasis through vaginal metabolic profiling

The Role of 17β-Estrogen in Candida albicans Adhesion on Human Vaginal Epithelial Cells via FAK Phosphorylation

Vaginal homeostasis features of Vulvovaginal Candidiasis through vaginal metabolic profiling

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