Candida bloodstream infections: comparison of species distribution and resistance to echinocandin and azole antifungal agents in Intensive Care Unit (ICU) and non-ICU settings in the SENTRY Antimicrobial Surveillance Program (2008–2009)

Pfaller, Michael A.; Messer, S. A.; Moet, Gary J.; Jones, Ronald N.; Castanheira, Mariana

doi:10.1016/j.ijantimicag.2011.02.016

Cited by 244 publications

(215 citation statements)

References 51 publications

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“…A high sensitivity of C. albicans to antifungal agents was observed, corroborating other published works 6,12,31 . As observed in Table 3, among the NCAC species (n=32), 31.2% of the isolates demonstrated SDD to fl uconazole, with 3.1% being resistant to amphotericin B (which corroborates published reports of high resistance of these species to antifungal agents) 9,13 .…”

Section: Discussionsupporting

confidence: 90%

“…As observed in Table 3, among the NCAC species (n=32), 31.2% of the isolates demonstrated SDD to fl uconazole, with 3.1% being resistant to amphotericin B (which corroborates published reports of high resistance of these species to antifungal agents) 9,13 . None of the isolates of C. glabrata were susceptible to fl uconazole, although 80% were SDD and 20% were resistant, in agreement with the fi ndings of other authors who described the low sensitivity of this species to triazol 32,33 .…”

Section: Discussionsupporting

confidence: 84%

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Antifungal susceptibility and distribution of Candida spp. isolates from the University Hospital in the municipality of Dourados, State of Mato Grosso do Sul, Brazil

Almeida

Shinobu-Mesquita

Svidzinski

et al. 2013

Rev. Soc. Bras. Med. Trop.

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Introduction: Hospital infections caused by Candida spp. are a leading cause of morbidity and mortality in hospitalized patients, particularly those that are critically ill or immunocompromised. In this study, the distributio n of Candida species in isolates from the University Hospital of the Federal University at Grande Dourados and their in vitro susceptibility to antifungal drugs were analyzed. Methods: Yeasts were phenotypically identifi ed using classical methodologies. Antifungal susceptibility tests to amphotericin B and fl uconazole were performed using the broth microdilution technique. Results: A total of 50 Candida isolates were obtained from hospitalized patients during the study period. We analyzed yeast isolates from urine (n=31; 62%), blood (n=12; 24%), and tracheal secretions (n=7; 14%). The following Candida species were identifi ed: C. tropicalis (n=21; 42%), C. albicans (n=18; 36%), C. glabrata (n=10; 20%), and C. krusei (n=1; 2%). Antifungal susceptibility tests demonstrated that C. albicans was susceptible to both antifungal agents. However, 31.2% of the non-C. albicans Candida isolates displayed dose-dependent susceptibility to fl uconazole, and 3.1% were resistant to amphotericin B. Conclusions: In contrast to previous reports, our results indicated that C. tropicalis was the most commonly isolated yeast species among the hospital patients. The predominance of non-C. albicans Candida infections confi rms the importance of species-level identifi cation for implementing appropriate antifungal therapies.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionsupporting

confidence: 84%

Antifungal susceptibility and distribution of Candida spp. isolates from the University Hospital in the municipality of Dourados, State of Mato Grosso do Sul, Brazil

Almeida

Shinobu-Mesquita

Svidzinski

et al. 2013

Rev. Soc. Bras. Med. Trop.

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“…Candida parapsilosis is the second or even the most prevalent species in many studies on candidaemia around the world (Krcmery & Barnes, 2002;Pereira et al, 2010;Pfaller et al, 2011). Both new cryptic members of the C. parapsilosis group, Candida orthopsilosis and Candida metapsilosis, have been associated with bloodstream infections or other anatomical sites (Kocsubé et al, 2007;Tavanti et al, 2007;Gomez-Lopez et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

Prevalence, distribution and antifungal susceptibility profiles of Candida parapsilosis, Candida orthopsilosis and Candida metapsilosis bloodstream isolates

Bonfietti

Martins

Szeszs

et al. 2012

Journal of Medical Microbiology

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“…2 Despite the increasing use of echinocandins, resistance remains uncommon in most Candida species, particularly in C. krusei. 3,4 Mutations in the Fks1 gene (encoding 1,3-β-D-glucan synthase) are correlated with reduced susceptibility. 5 We report here C. krusei breakthrough fungemia following exposure to prophylactic micafungin in HSC transplanted patients.…”

mentioning

confidence: 99%

Development of echinocandin resistance in Candida krusei isolates following exposure to micafungin and caspofungin in a BM transplant unit

Tavernier

Desnos‐Ollivier

Honeyman

et al. 2014

Bone Marrow Transplant

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Candida bloodstream infections: comparison of species distribution and resistance to echinocandin and azole antifungal agents in Intensive Care Unit (ICU) and non-ICU settings in the SENTRY Antimicrobial Surveillance Program (2008–2009)

Cited by 244 publications

References 51 publications

Antifungal susceptibility and distribution of Candida spp. isolates from the University Hospital in the municipality of Dourados, State of Mato Grosso do Sul, Brazil

Antifungal susceptibility and distribution of Candida spp. isolates from the University Hospital in the municipality of Dourados, State of Mato Grosso do Sul, Brazil

Prevalence, distribution and antifungal susceptibility profiles of Candida parapsilosis, Candida orthopsilosis and Candida metapsilosis bloodstream isolates

Development of echinocandin resistance in Candida krusei isolates following exposure to micafungin and caspofungin in a BM transplant unit

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