Candidate gene association analysis of multiple sclerosis in the Jordanian Arab population: A case-control study

AL-Eitan, Laith N.; Qudah, Malak Al; Qawasmeh, Majdi Al

doi:10.1016/j.gene.2020.144959

Cited by 9 publications

(8 citation statements)

References 20 publications

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“…The study conducted by Zong-Li Xia et al., found correlation between genotypes in SNPs rs12722489 and rs2104286 ( IL2RA gene) and MS diagnosis in the Hui and Han nationalities ( 75 ). The SNPs association rs6897932 was found in Jordanian MS patients ( 76 ). The rs9282860 in STK11 gene was linked to a high likelihood of MS in women in the United States ( 77 ).…”

Section: Discussionmentioning

confidence: 99%

Analysis of herpesvirus infection and genome single nucleotide polymorphism risk factors in multiple sclerosis, Volga federal district, Russia

et al. 2022

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Multiple sclerosis (MS) is a heterogeneous disease where herpesvirus infection and genetic predisposition are identified as the most consistent risk factors. Serum and blood samples were collected from 151 MS and 70 controls and used to analyze circulating antibodies for, and DNA of, Epstein Barr virus (EBV), human cytomegalovirus (HCMV), human herpes virus 6 (HHV6), and varicella zoster virus (VZV). The frequency of selected single nucleotide polymorphisms (SNPs) in MS and controls were studied. Herpesvirus DNA in blood samples were analyzed using qPCR. Anti-herpesvirus antibodies were detected by ELISA. SNPs were analyzed by the allele-specific PCR. For statistical analysis, Fisher exact test, odds ratio and Kruskall–Wallis test were used; p<0.05 values were considered as significant. We have found an association between circulating anti-HHV6 antibodies and MS diagnosis. We also confirmed higher frequency of A and C alleles in rs2300747 and rs12044852 of CD58 gene and G allele in rs929230 of CD6 gene in MS as compared to controls. Fatigue symptom was linked to AC and AA genotype in rs12044852 of CD58 gene. An interesting observation was finding higher frequency of GG genotype in rs12722489 of IL2RA and T allele in rs1535045 of CD40 genes in patient having anti-HHV6 antibodies. A link was found between having anti-VZV antibodies in MS and CC genotype in rs1883832 of CD40 gene.

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Section: Discussionmentioning

confidence: 99%

Analysis of herpesvirus infection and genome single nucleotide polymorphism risk factors in multiple sclerosis, Volga federal district, Russia

et al. 2022

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“…Al-Eitan et al [ 22 ], in a case-control association study involving 218 MS patients and 227 controls from the Jordan Arab population, described a modest association between the rs2365095 SNV and MS risk, while they found no association of rs2365095, rs1922452, rs951818, rs870849, rs1882551, and rs11227 with MS. Furthermore, they also described a lack of association of rs2365095, rs1922452, rs951818, rs870849, rs1882551, and rs11227 SNVs with MS duration, age at MS onset, EDSS score at presentation, and clinical form of MS [ 23 ].…”

Section: Discussionmentioning

confidence: 99%

“…Despite LAG3/CD4 genes, SNVs have not been found to be associated with the risk for MS in GWAS, and taking into account the previously commented possible relationship between LAG3 protein and MS, it seems reasonable to investigate the possible association between LAG3/CD4 SNVs in the risk for MS. This issue has been of the topic of several studies, although the results have been controversial [ 20 , 21 , 22 , 23 ]. The current replication study aimed to establish whether the most common SNVs in these genes showed an association with the risk of MS in the Spanish Caucasian population.…”

Section: Introductionmentioning

confidence: 99%

Association between LAG3/CD4 Genes Variants and Risk for Multiple Sclerosis

García‐Martín

Agúndez

Gómez-Tabales

et al. 2022

IJMS

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Several recent works have raised the possibility of the contribution of the lymphocyte activation gene 3 (LAG3) protein in the inflammatory processes of multiple sclerosis (MS). Results of studies on the possible association between LAG3 gene variants and the risk of MS have been inconclusive. In this study, we tried to show the possible association between the most common single nucleotide variants (SNVs) in the CD4 and LAG3 genes (these two genes are closely related) and the risk of MS in the Caucasian Spanish population. We studied the genotypes and allelic variants CD4 rs1922452, CD4 rs951818, and LAG3 rs870849 in 300 patients diagnosed with MS and 400 healthy patients using specific TaqMan-based qPCR assays. We analyzed the possible influence of the genotype frequency on age at the onset of MS, the severity of MS, clinical evolutive subtypes of MS, and the HLADRB1*1501 genotype. The frequencies of the CD4 rs1922452, CD4 rs951818, and LAG3 rs870849 genotypes and allelic variants were not associated with the risk of MS and were unrelated to gender, age at onset and severity of MS, the clinical subtype of MS, and HLADRB1*1501 genotype. The results of the current study showed a lack of association between the CD4 rs1922452, CD4 rs951818, and LAG3 rs870849 SNVs and the risk of developing MS in the Caucasian Spanish population.

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“…SNPs 6883680 (rs1941881771) and 6883700 (rs2365095) are located in the third intronic region. LAG3 rs2365095 has been found to be associated with multiple sclerosis in the Jordanian Arab population [13]. SNP 6886722 (rs199912414) is located in the sixth intronic region, and no association with disease was found in the past.…”

Section: Analytical Cellular Pathologymentioning

confidence: 99%

Lymphocyte Activation Gene 3 Single-Nucleotide Polymorphisms in Bone Marrow Failure Diseases

Sun

Cao

Zhao

et al. 2022

Analytical Cellular Pathology

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Introduction. Lymphocyte activation gene 3 (LAG3) is an inhibitory checkpoint protein expressed on activated T effector, T regulatory, and natural killer cells. The main function of LAG3 is the regulation of immune homeostasis. Several studies have suggested its role in malignant and autoimmune diseases. The objective of this study was to explore the association between LAG3 single-nucleotide polymorphisms (SNPs) and bone marrow failure diseases. Methods. Sixty-two patients newly diagnosed with bone marrow failure diseases in the Hematology Department of Tianjin Medical University General Hospital between January 2019 and December 2020 and 16 healthy controls were enrolled in this study. SNPs in LAG3 were investigated by performing Sanger sequencing, and the association of the detected SNPs with bone marrow failure diseases was analyzed. Results. Eleven SNPs were identified. Among them, the frequency of LAG3 rs1941928301 (C>T) was statistically different among the groups ( P = 0.013 ). It was higher in the myelodysplastic syndrome (MDS) group than that in the severe aplastic anemia (SAA) group ( P = 0.004 ) and that in the healthy control group ( P = 0.009 ). Conclusions. LAG3 rs1941928301 (C>T) might be associated with a higher risk of MDS. The detected LAG3 SNPs have no apparent effect on susceptibility to SAA and immune-related pancytopenia (IRP).

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Candidate gene association analysis of multiple sclerosis in the Jordanian Arab population: A case-control study

Cited by 9 publications

References 20 publications

Analysis of herpesvirus infection and genome single nucleotide polymorphism risk factors in multiple sclerosis, Volga federal district, Russia

Analysis of herpesvirus infection and genome single nucleotide polymorphism risk factors in multiple sclerosis, Volga federal district, Russia

Association between LAG3/CD4 Genes Variants and Risk for Multiple Sclerosis

Lymphocyte Activation Gene 3 Single-Nucleotide Polymorphisms in Bone Marrow Failure Diseases

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