Candidate gene study for smoking, alcohol use, and body weight in a sample of pregnant women

Wehby, George L.; Prater, Kaitlin; Ryckman, Kelli K.; Kummet, Colleen; Murray, Jeffrey C.

doi:10.3109/14767058.2014.932768

Cited by 4 publications

(3 citation statements)

References 56 publications

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“…Early pregnancy BMI was not associated with gene SNPs in our study. Out of four studies that examined an FTO association with prepregnancy BMI, three found an association [2, 8, 10]: in a Brazilian sample (primarily self-reported black skin) [2]; in a UK sample (unknown racial/ethnic group) [8]; and in Danish women [10]. In the fourth study, in a US African American sample no association was found [6].…”

Section: Discussionmentioning

confidence: 99%

“…Several studies have examined obesity and diabetes genes on prepregnancy weight, GWG and/or weight retention [2, 6–10] with inconsistent findings due to variations in sample size, methodology, racial/ethnic sample composition, and candidate gene SNP selection. The FTO gene was associated with high prepregnancy BMI in a sample from Brazil (73.5% self-reported black/mixed) [2] and in a sample from the United Kingdom of unreported racial/ethnic groups [8].…”

Section: Introductionmentioning

confidence: 99%

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Obesity candidate genes, gestational weight gain, and body weight changes in pregnant women

Groth

Lalonde

et al. 2018

Nutrition

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The FTO gene and possibly the GNB3 gene are associated with high gestational weight gain in obese black women. Obese carriers of the FTO risk allele gained 4.1 kg (AT) and 7.6 kg (TT) more than those without risk alleles. Overweight GNB3 heterozygotes (CT) gained 6.6 kg less than homozygotes (CC). Overweight or obese black women who have either risk variant are at risk for high gestational weight gain.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Obesity candidate genes, gestational weight gain, and body weight changes in pregnant women

Groth

Lalonde

et al. 2018

Nutrition

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“…While much of this genetic etiology remains unidentified, numerous studies have identified loci that are associated with in the general population. SNPs in FTO gene have been found significantly associated with pre-pregnancy obesity and body mass index in pregnant women [ 24 ]. Moreover, relationship between gene polymorphisms in PPARG [ 25 ] and overweight and obesity have also been reported.…”

Section: Introductionmentioning

confidence: 99%

Association study of rs1801282 PPARG gene polymorphism and immune cells and cytokine levels in a Spanish pregnant women cohort and their offspring

et al. 2020

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Background Peroxisome proliferator activated receptor gamma (PPARG) belongs to the nuclear receptor superfamily functioning as transcription factors to regulate cellular differentiation, development and metabolism. Moreover, it has been implicated in the regulation of lipid metabolism, as well as the maturation of monocytes/macrophages and the control of inflammatory reactions. The aim of this study was to evaluate the relationship between the Pro12Ala (rs1808212) PPARG gene polymorphism on immune molecular and cellular components in mothers and their offspring participating in the PREOBE study. Methods DNA from maternal venous blood samples at 24, 34 and 40 gestational weeks, plus cord blood samples was extracted. Pro12Ala PPARG polymorphism genotyping was performed, and immune system markers were analyzed by flow cytometry. Results Study findings revealed no effect of rs1808212 PPARG genotypes on innate immune parameters in mothers and their offspring; however, CD4 + /CD8 + ratio were decreased at 24 and 34 weeks in pregnant women carrying the CG (Pro12Ala) rs1808212 polymorphism, (p = 0,012 and p = 0,030; respectively). Only CD19 levels in peripheral blood were significantly higher at delivery in pregnant women carrying the CC (Pro12Pro) genotype (p ≤ 0.001). Moreover, there were statistically significant differences in leukocytes and neutrophils maternal levels at 34 weeks of gestation, being lower in carriers of Pro12Ala genotype (p = 0.028 and p = 0.031, respectively). Conclusions Results suggest that Pro12Ala PPARG polymorphism may have an effect on some cell and immune parameters in pregnant women during pregnancy and at time of delivery. However, newborn innate immune system does not seems to be influenced by PPARG Pro12Ala polymorphism in cord blood.

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The association between the FTO gene variant and alcohol consumption and binge and problem drinking in different gene-environment background: The HAPIEE study

Hubacek

Pikhart

Peasey

et al. 2019

Gene

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BACKGROUND: Alcohol intake and tobacco smoking have significant negative health consequences and both are influenced by genetic predispositions. Some studies suggest that the FTO gene is associated with alcohol consumption. We investigated whether a tagging variant (rs17817449) within the FTO gene is associated with alcohol intake, problem drinking and smoking behaviour. METHODS: We analysed data from 26,792 Caucasian adults (47.2% of males; mean age 58.9 (±7.3) years), examined through the prospective cohort HAPIEE study. The primary outcomes were daily alcohol consumption, binge drinking, problem drinking (CAGE score 2+) and smoking status in relation to tagging variants within the FTO and ADH1B genes. RESULTS: We found no significant association of the FTO polymorphism with smoking status in either sex. The associations of the FTO polymorphism with drinking pattern were inconsistent and differed by gender. In men, GG homozygote carriers had lower odds of problem drinking (OR 0.85, 95% CI 0.75-0.96, p=0.03). In women, the combination of the FTO/ADH1B GG/+A genotypes doubled the risk of binge drinking (OR 2.10, 95% CI 1.19-3.71, p<0.05), and the risk was further increased among smoking women (OR 4.10, 95% CI 1.64-10.24, p=0.008). CONCLUSIONS: In this large population study, the FTO gene appeared associated with binge and problem drinking, and the associations were modified by sex, smoking status and the ADH1B polymorphism.

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Candidate gene study for smoking, alcohol use, and body weight in a sample of pregnant women

Cited by 4 publications

References 56 publications

Obesity candidate genes, gestational weight gain, and body weight changes in pregnant women

Obesity candidate genes, gestational weight gain, and body weight changes in pregnant women

Association study of rs1801282 PPARG gene polymorphism and immune cells and cytokine levels in a Spanish pregnant women cohort and their offspring

The association between the FTO gene variant and alcohol consumption and binge and problem drinking in different gene-environment background: The HAPIEE study

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