The association between the FTO gene variant and alcohol consumption and binge and problem drinking in different gene-environment background: The HAPIEE study

Abstract

BACKGROUND: Alcohol intake and tobacco smoking have significant negative health consequences and both are influenced by genetic predispositions. Some studies suggest that the FTO gene is associated with alcohol consumption. We investigated whether a tagging variant (rs17817449) within the FTO gene is associated with alcohol intake, problem drinking and smoking behaviour. METHODS: We analysed data from 26,792 Caucasian adults (47.2% of males; mean age 58.9 (±7.3) years), examined through the prospective cohort HAPIEE study. The primary outcomes were daily alcohol consumption, binge drinking, problem drinking (CAGE score 2+) and smoking status in relation to tagging variants within the FTO and ADH1B genes. RESULTS: We found no significant association of the FTO polymorphism with smoking status in either sex. The associations of the FTO polymorphism with drinking pattern were inconsistent and differed by gender. In men, GG homozygote carriers had lower odds of problem drinking (OR 0.85, 95% CI 0.75-0.96, p=0.03). In women, the combination of the FTO/ADH1B GG/+A genotypes doubled the risk of binge drinking (OR 2.10, 95% CI 1.19-3.71, p<0.05), and the risk was further increased among smoking women (OR 4.10, 95% CI 1.64-10.24, p=0.008). CONCLUSIONS: In this large population study, the FTO gene appeared associated with binge and problem drinking, and the associations were modified by sex, smoking status and the ADH1B polymorphism.

Coffee Types and Type 2 Diabetes Mellitus: Large-Scale Cross-Phenotype Association Study and Mendelian Randomization Analysis

“…Moreover, in the crossphenotype association study, the notable identified SNP rs10492872 mapped to FTO is shared by two trait pairs of ground coffee/BMI and instant coffee/BMI, and its effects on ground coffee and instant coffee are in opposite directions, so as rs11660753 mapped to SMIM21 (Tables 1C, D). FTO gene is the first candidate gene of obesity, and it is also related to a variety of other phenotypes, such as alcohol intake (36), C-reactive protein levels (37), etc. A recent study has found that FTO can help cancer cells escape immune surveillance (38).…”

Interactions of anthropometric indices, rs9939609 FTO gene polymorphism and breast cancer: A case‐control study

“…A recent study indicated that the effect of FTO polymorphisms on alcohol consumption may be altered under different environmental conditions. 32 However, there were some limitations in our present study. First, different types of BC including the status of hormone receptors and also the stage of BC were not considered.…”

“…However, Hubacek et al found no association between this polymorphism and alcohol consumption. A recent study indicated that the effect of FTO polymorphisms on alcohol consumption may be altered under different environmental conditions 32 …”

Coffee Types and Cardiac Metabolic Risks: Large-scale Cross-phenotype Association Study and Mendelian Randomization Analysis

“…Moreover, in the cross-phenotype association study, the notable identi ed SNP rs10492872 mapped to FTO is shared by two trait pairs of ground coffee/BMI and instant coffee/BMI, and its effects on ground coffee and instant coffee are in opposite directions, so as rs11660753 mapped to SMIM21 (Table 1). FTO gene is the rst candidate gene of obesity, and it is also related to a variety of other phenotypes, such as alcohol intake [40], C-reactive protein levels [41], etc. A recent study has found that FTO can help cancer cells escape immune surveillance [42].…”