‘Candidatus Mycoplasma haematoparvum’, a novel small haemotropic mycoplasma from a dog

Sykes, Jane E.; Ball, Louise M.; Bailiff, Nathan L.; Fry, Michael M.

doi:10.1099/ijs.0.02989-0

Cited by 72 publications

(49 citation statements)

References 16 publications

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“…A total of 147 dogs with at least one laboratory abnormality (leucopenia, thrombocytopenia, pancytopenia, or anemia) were tested, resulting in 2 (1.4%) positive samples for M. haemocanis and 11 (7.5%) for 'Candidatus M. haematoparvum'. However, the sequenced PCR amplicons of 'Candidatus M. haematoparvum' were only 85% similar to the 'Candidatus M. haematoparvum' described by Sykes et al (2005), but showed 96% homology to M. haemofelis and 96% to M. haemocanis. Results suggested that, although amplified by a standard 'Candidatus M. haematoparvum' PCR protocol, this particular species of hemoplasma is phylogenetically closer to M. haemocanis than to 'Candidatus M. haematoparvum'.…”

Section: Companion Animalsmentioning

confidence: 99%

A review of the occurrence of hemoplasmas (hemotrophic mycoplasmas) in Brazil

Biondo¹,

Santos²,

Guimarães³

et al. 2009

RBPV

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Recent studies have been conducted in Brazil using molecular techniques for the detection of hemotrophic mycoplasmas in several mammals. In domestic cats, Mycoplasma haemofelis, 'Candidatus M. haemominutum', and 'Candidatus M. turicensis' infections have been identified. These species have also been found in free-ranging and captive neotropical felid species. Two canine hemoplasmas, Mycoplasma haemocanis and 'Candidatus Mycoplasma haematoparvum', have been identified in dogs. In commercial swine populations, Mycoplasma suis was found to be highly prevalent, especially in sows. Moreover, novel mycoplasma species have been identified in Brazilian commercial pigs and domestic dogs. A hemoplasma infection in a human patient infected with the human immunodeficiency virus (HIV) was also recently documented. In conclusion, hemoplasma species are common and important infectious agents in Brazil. Further studies should be conducted to better understand their impact on pets, production animals, and wildlife fauna, as well as their role as zoonotic agents, particularly in immunocompromised patients.Keywords: Hemoplasma, Mycoplasma haemofelis, Mycoplasma suis, HIV. ResumoEstudos recentes utilizando técnicas moleculares para a detecção de micoplasmas hemotróficos em diferentes mamíferos têm sido conduzidos no Brasil. Em gatos domésticos, infecções por Mycoplasma haemofelis, 'Candidatus M. haemominutum' e 'Candidatus M. turicensis' foram identificadas. Estas espécies também foram encontradas em felídeos neotropicais de vida livre e de cativeiro. Dois hemoplasmas caninos, Mycoplasma haemocanis e 'Candidatus Mycoplasma haematoparvum', foram identificados em cães domésticos. Em populações comerciais de suínos, Mycoplasma suis possui alta prevalência, especialmente em porcas. Além disso, novas espécies de hemoplasmas foram detectadas em suínos comercias e cães. Infecção por um hemoplasma em um paciente humano infectado com o vírus da imunodeficiência humana (HIV) foi recentemente documentada. Em conclusão, espécies de hemoplasmas são comuns e importantes agentes de infecções no Brasil. Estudos futuros devem ser conduzidos para melhor entender seu impacto em cães e gatos, animais de produção e na fauna silvestre, e também para determinar o seu papel como agentes zoonóticos, particularmente em pacientes imunocomprometidos.Palavras-chave: Hemoplasma, Mycoplasma haemofelis, Mycoplasma suis, HIV.

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Section: Companion Animalsmentioning

confidence: 99%

A review of the occurrence of hemoplasmas (hemotrophic mycoplasmas) in Brazil

Biondo¹,

Santos²,

Guimarães³

et al. 2009

RBPV

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“…In small animals, multiple hemoplasma species have been characterized, including feline hemoplasmas such as Mycoplasma haemofelis, 'Candidatus Mycoplasma haemominutum' and 'Candidatus Mycoplasma turicensis' [5,17,18], and canine hemoplasmas such as Mycoplasma haemocanis and 'Candidatus Mycoplasma haematoparvum' [8,15]. M. haemofelis induces more severe clinical symptoms in the feline host than 'Candidatus M. haemominutum' [2,7], and 'Candidatus M. turicensis' has been reported to be a similarly weak pathogen [3].…”

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Comparison of the Effect of Two Hemoplasma Species on Hematological Parameters in Cattle

Tagawa

Matsumoto

Yokoyama

et al. 2010

The Journal of Veterinary Medical Science

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ABSTRACT. Mycoplasma wenyonii and 'Candidatus Mycoplasma haemobos' are pathogens associated with bovine hemoplasmosis. Hematological parameters of these two hemoplasma species were compared in a cattle herd that was known to be infected with these 2 pathogens. 'C. M. haemobos'-infected cattle exhibited lower red blood cell levels, hemoglobin concentrations and packed cell volumes than M. wenyonii-infected cattle and hemoplasma-negative controls. On the other hand, cattle infected with M. wenyonii did not show any significant differences in hematological parameters compared with the hemoplasma-negative cattle.

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“…Various hemoplasmas have been detected in other animals [12,13,18], and pathogenic differences among them have been reported [2,3,14]. The phylogenetic analysis revealed that both 'Candidatus M. haemovis' and M. ovis belong to the same clade, which contains lower pathogenic species that infect other animals.…”

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A Clinical Case of Severe Anemia in a Sheep Coinfected with Mycoplasma ovis and Candidatus Mycoplasma haemovis' in Hokkaido, Japan

et al. 2012

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ABSTRACT. A 2-year-old East Friesian sheep imported from Australia exhibited severe anemia after contagious pustular dermatitis in Hokkaido, Japan. Hemoplasma infection was confirmed in blood smears. Both Mycoplasma ovis and 'Candidatus Mycoplasma haemovis' were detected by PCR and sequence analyses. In the epidemiological analysis, dual pathogens were detected in 6 of 12 (50.0%) sheep imported from Australia with the infected ewe at the same time, 1 of 5 (20.0%) sheep introduced from a domestic farm in Hokkaido, and in 1 of 16 (6.3%) sheep from an epidemiologically unrelated ranch. It is the first clinical case of sheep to confirm coinfection of these pathogens in Japan. Haemobartonella and Eperythrozoon cause infectious anemia in several mammalian species [8,17]. These pathogens have recently been reclassified as genus Mycoplasma on the basis of 16S rRNA gene analysis and morphological similarities [8]. Mycoplasma ovis (formerly Eperythrozoon ovis) causes ovine hemoplasmosis, which is characterized by poor weight gain, severe anemia, and even mortality in lambs and, occasionally, young adult sheep [1]. On the other hand, chronic sustained infection can occur asymptomatically in older sheep [4]. M. ovis also causes a more severe disease in goats [7]. Recently 'Candidatus Mycoplasma haemovis', a new ovine hemoplasma, has been detected in Hungary [5]. This is the first case report to describe M. ovis and 'Candidatus M. haemovis' coinfection in a sheep presenting with severe anemia in Japan.A 2-year-old East Friesian ewe imported from Australia in July 2009 showed contagious pustular dermatitis a month after import. Because anorexia continued after recovery, a blood test was carried out. Severe anemia with hematocrit of 14% was recorded. Erythrocytes with coccoid parasites on their surface were detected in a blood smear (Fig. 1), which strongly suggested infectious hemoplasma. An EDTA-anticoagulated blood sample was collected from the infected ewe. For the epidemiological study, blood was randomly collected from 12 sheep imported from Australia with the infected ewe at the same time, and were managed at a same sheep building until an investigation and, 5 sheep introduced from a domestic farm in Hokkaido. Additionally blood samples were also collected from 16 sheep kept in an epidemiologically unrelated ranch. It was geographically apart from the first ranch, and no movement of sheep has been recorded between the two ranches.Total DNA was extracted from 200 μl of blood using a QIAamp DNA Blood Mini Kit (QIAGEN, Hilden, Germany) and stored at -30ºC until use. For screening, PCR amplification was performed in a 25 μl reaction mixture containing 5 μl of each DNA template and an F2/R2 hemoplasma-specific primer set [6]. Longer 16S rRNA * CORRESPONDENCE TO: INOKUMA, H., Obihiro University of Agriculture and Veterinary Medicine, 080-8555 Obihiro, Japan. e-mail: inokuma@obihiro.ac.jp ©2012 The Japanese Society of Veterinary Science Fig. 1. Giemsa-stained blood smear from the anemic sheep with Mycoplasma ovis and 'Candidat...

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‘Candidatus Mycoplasma haematoparvum’, a novel small haemotropic mycoplasma from a dog

Cited by 72 publications

References 16 publications

A review of the occurrence of hemoplasmas (hemotrophic mycoplasmas) in Brazil

A review of the occurrence of hemoplasmas (hemotrophic mycoplasmas) in Brazil

Comparison of the Effect of Two Hemoplasma Species on Hematological Parameters in Cattle

A Clinical Case of Severe Anemia in a Sheep Coinfected with Mycoplasma ovis and Candidatus Mycoplasma haemovis' in Hokkaido, Japan

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