Candidemia caused by amphotericin B and Fluconazole resistant Candida auris

Sarma, Satyam; Kumar, Nitin; Sk, Sharma; Govil, Deepak; Ali, Tarik E.; Mehta, Yatin; Rattan, Ashok

doi:10.4103/0255-0857.108746

Cited by 79 publications

(63 citation statements)

References 5 publications

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“…There have been a handful of reports on C. auris as a pathogen causing fungemia [9,10] but in this case C. auris was found as the causative agent for vulvovaginitis. The increasing isolation of C. auris from various clinical specimens clearly indicates its ability to colonise, invade and cause disease with varying severity.…”

Section: Discussionmentioning

confidence: 86%

Itraconazole-resistant Candida auris with phospholipase, proteinase and hemolysin activity from a case of vulvovaginitis

Kumar

Banerjee

Pratap

et al. 2015

J Infect Dev Ctries

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Since the emergence of pathogenic non-albicans Candida species, a number of new isolates have been added to the list. One such unusual species is Candida auris (C. auris), recently isolated and studied in few reports. In this study, a case of vulvovaginitis caused by Candida auris incidentally identified by molecular methods using internal transcribed spacer polymerase chain reaction (ITS PCR) is described. Antifungal susceptibility testing revealed the isolate to be resistant to itraconazole (MIC ≥ 2 µg/ml) and expressed important virulence factors including phospholipase, proteinase and hemolysin activity. The patient was successfully treated with oral fluconazole and did not have any invasive fungemia. Very few cases of this emerging pathogen have been reported. However, its isolation from clinical specimens reveals the significance of nonalbicans candida species over C. albicans and the diversity of Candida spp causing infections.

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Section: Discussionmentioning

confidence: 86%

Itraconazole-resistant Candida auris with phospholipase, proteinase and hemolysin activity from a case of vulvovaginitis

Kumar

Banerjee

Pratap

et al. 2015

J Infect Dev Ctries

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“…Around the same time, 15 isolates of C. auris were recovered from 15 patients in a tertiary care hospital in Northern India 13. These isolates were initially identified as C. haemulonii , but were later confirmed as C. auris upon sequencing.…”

Section: Epidemiologymentioning

confidence: 99%

“…Infections have been reported in patients of all ages, from preterm infants to the elderly. Further study may be needed to learn more about risk factors associated with C. auris infection 13,26–29…”

Section: Who Is At Risk?mentioning

confidence: 99%

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Current perspective on emergence, diagnosis and drug resistance in <em>Candida auris</em>

Sarma

Upadhyay

2017

IDR

120

135

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Candida auris is an emerging fungus that presents a serious threat to global health. The organism is difficult to identify using conventional biochemical methods. C. auris has also attracted attention because of its reduced susceptibility to azoles, polyenes, and echinocandins, with a few strains even resistant to all three classes of antifungals. In this review paper we discuss the trends in emergence of C. auris in different parts of the world, associated risk factors, drug resistance, and diagnostic challenges. Strategies for prevention and therapeutic options for such infections is also addressed.

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“…(1) Cases of invasive non albicans candidiasis have been reported from many parts of the world. Among the non albicans Candida species; C. glabrata and C. tropicalis have emerged as important opportunistic pathogens with other species being reported to a lesser degree.…”

Section: Candidaemia and Candidiasis Are Usually Caused Bymentioning

confidence: 99%

<i>Candida auris</i> infection: How prepared is Nigeria for this emerging fungal agent?

Fayemiwo¹,

Makanjuola²

2017

Af J Clin Exp Micro

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Reports from Asia and other parts of the world have demonstrated that the incidence of Candida auris infection is on the rise. Candida auris is a fungal pathogen causing a wide variety of infections affecting people of all age groups. Candida auris was first described in 2009 and has since emerged as an important cause of invasive fungal infection, most importantly healthcareassociated candidaemia. Large outbreaks have been reported worldwide, with therapeutic failure and associated high mortality rates recorded. The emergence and spread of C. auris raises public health concerns because of some characteristics of this pathogen. First it is resistant to many antifungal agents making this infection very difficult to treat. It is also associated with horizontal transmission in health care settings causing outbreaks among hospitalized individuals with high mortality rates. Furthermore, identification of C auris is a challenge. Routine identification methods usually misidentify the organism as other yeasts especially Candida haemulonii. This review discusses the current knowledge on the epidemiology, treatment and control of this infection. The urgent need for the stakeholders in Nigerian tertiary hospitals to set machinery in motion for prompt diagnosis, management and prevention of transmission of this infection are also discussed.

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Candidemia caused by amphotericin B and Fluconazole resistant Candida auris

Cited by 79 publications

References 5 publications

Itraconazole-resistant Candida auris with phospholipase, proteinase and hemolysin activity from a case of vulvovaginitis

Itraconazole-resistant Candida auris with phospholipase, proteinase and hemolysin activity from a case of vulvovaginitis

Current perspective on emergence, diagnosis and drug resistance in <em>Candida auris</em>

<i>Candida auris</i> infection: How prepared is Nigeria for this emerging fungal agent?

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