“…The organisms associated with CRBSI are usually the normal resident flora of the skin at the insertion site, which may lead to colonization of the catheter inserted. Gram-positive cocci are responsible for at least two-thirds of the infections and coagulase-negative staphylococci (60%) are the leading bacteria cultured from catheters, followed by gram negative cocci [9,10]. Additionally, microbial biofilms may pose a public health problem for persons requiring indwelling medical devices [11].…”