Canine bone marrow cytological examination, classification and reference values: A retrospective study of 295 cases

Turinelli, Vanessa; Gavazza, Alessandra; Stock, Graham; Fournel‐Fleury, C.

doi:10.1016/j.rvsc.2015.10.008

Cited by 9 publications

(19 citation statements)

References 13 publications

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“…6 However, this finding differs significantly from what has been observed in dogs, in which dysmyelopoiesis appears to be rare and myelodysplastic syndrome very rare. 2 Dyserythropoiesis was often associate with peripheral anaemia alone, or bicytopenia or pancytopenia (36.4%, 27.3% and 27.3%, respectively), and was characterised by the presence of morphological abnormalities of the erythroid cells and abnormal maturation of the erythroid lineage. The other cell lineages were not affected.…”

Section: Discussionmentioning

confidence: 99%

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Retrospective study of 152 feline cytological bone marrow examinations: preliminary classification and ranges

Turinelli¹,

Gavazza

2018

Journal of Feline Medicine and Surgery

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Section: Discussionmentioning

confidence: 99%

“…The most common indications in cats are persistent non-regenerative anaemia, neutropenia, abnormal blood cell morphology or unexplained presence of immature cells in blood. 1,2…”

Section: Introductionmentioning

confidence: 99%

Retrospective study of 152 feline cytological bone marrow examinations: preliminary classification and ranges

Turinelli¹,

Gavazza

2018

Journal of Feline Medicine and Surgery

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“…In the examinations of bone marrow smears, 1000 cells were evaluated on each slide, and the cellularity, myeloid-to-erythroid (M-E) ratios, and blast cell to all nucleated cell (ANC) ratios were evaluated as previously described [18]. In addition, granulocyte maturation ratio and erythroid maturation ratio were investigated as previously reported [20].…”

Section: Clinical and Clinicopathological Features Of Bone Marrow Dismentioning

confidence: 99%

Clinical and clinicopathological features and outcomes of Miniature Dachshunds with bone marrow disorders

Tani

Tomiyasu

Ohmi

et al. 2020

The Journal of Veterinary Medical Science

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Non-neoplastic bone marrow disorders such as non-regenerative immune-mediated anemia, pure red cell aplasia, and myelodysplastic syndrome are major causes of nonregenerative anemia in dogs. However, there has been no study on the clinical and clinicopathological features of canine non-neoplastic bone marrow disorders in Japan. Hence, we first investigated the breed disposition of non-neoplastic bone marrow disorders that induce anemia as a retrospective study and found that Miniature Dachshund (MD) was a predisposed breed. Based on this finding, we investigated the clinical and clinicopathological features of non-neoplastic bone marrow disorders in MDs as a preliminary retrospective study, and we compared them between immunosuppressive treatment-responsive and-resistant MDs. We found that treatmentresistant MDs showed thrombocytosis and increased frequencies of dysplastic features in the peripheral blood. These results indicate that bone marrow disorders in treatmentresistant MDs might manifest distinct features compared with those in treatmentsensitive MDs, and sensitivity to immunosuppressive treatments could be predicted based on thrombocytosis and dysplastic features in the peripheral blood. Further studies that examine aberrations in the genome are needed to elucidate the pathophysiology of bone marrow disorders in MDs.

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“…Other important indications of bone marrow cytological examination, that are not always related to hemogram alterations and that can be associated to normal cytology-histology are hypercalcemia, hyperproteinemia, fever of unexplained origin, staging for malignancies, and monitoring of chemotherapy administration ( Harvey, 2012 ; Raskin and Messick, 2012 ; Turinelli et al , 2015 ). However, in those cases, a normal bone marrow cytology or histology should not pose real interpretative problems.…”

Section: Introductionmentioning

confidence: 99%

“…So far, few retrospective studies of bone marrow examination have been published and only one study provided bone marrow differential cell counting for different diseases ( Weiss, 2006 ; Turinelli et al , 2015 ).…”

Section: Introductionmentioning

confidence: 99%

Retrospective study of 613 canine cytologically normal bone marrows associated to altered hemograms: Description, possible interpretation and review of the principal physiological hematopoietic mechanisms

Turinelli¹,

Rossi²,

Gavazza³

2023

Open Vet J

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Background: In clinical routine, it can happen that to an abnormal hemogram corresponds an unexpected cytological normal bone marrow examination that can be difficult to interpret and to menage. Aim: This cytologically retrospective study wants to evaluate a consistent number of qualitative and quantitative normal bone marrow exams according to the hematological and clinical-pathological data to judge if this normality is by itself a pathologic state. Methods: Six hundred and thirteen bone marrow samples were examined. The bone marrow cytological examinations were performed using morphological and numerical criteria together with a complete hemogram, after the identification of clinical or hematological alterations such as multiple lymph nodes enlarged, positive leishmania serological result, staging of neoplasia, cytopenia, increased number of cells or suspicion of malignant blood disorders. Results: Of the 613 bone marrow samples evaluated, 85 (14%) were classified as normal or without cytological abnormalities; however only 28 (33%) of those cases has a normal hemogram associated, whereas 55 (65%) has one or more cytopenia and 2 (2%) has increased blood cells count. Conclusion: From this study emerge that cytological bone marrow examinations without any morphological or numerical abnormalities are often associated with altered hematological exams and for this reason they should not be considered normal and should lead to other deepened investigations.

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Canine bone marrow cytological examination, classification and reference values: A retrospective study of 295 cases

Cited by 9 publications

References 13 publications

Retrospective study of 152 feline cytological bone marrow examinations: preliminary classification and ranges

Retrospective study of 152 feline cytological bone marrow examinations: preliminary classification and ranges

Clinical and clinicopathological features and outcomes of Miniature Dachshunds with bone marrow disorders

Retrospective study of 613 canine cytologically normal bone marrows associated to altered hemograms: Description, possible interpretation and review of the principal physiological hematopoietic mechanisms

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