Canine eosinophilic folliculitis and furunculosis in three cases

Curtis, Cathy; Bond, R.; Blunden, A. S.; Thomson, D. G.; McNeil, P. E.; Whitbread, T.

doi:10.1111/j.1748-5827.1995.tb02850.x

Cited by 13 publications

(10 citation statements)

References 4 publications

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“…1,3,5,8,11 Depending on the severity of the lesion, epidermal hyperplasia, erosions, ulcerations, and variable amounts of spongiosis and necrosis may be present. 6,9,12,13 The so-called "flame figures," collagen fibers surrounded by degranulated eosinophils, are a commonly described finding but are not unique to this condition. 2,3,5,9 The histopathological appearance can vary but is consistent within the location of the lesion and its chronicity and severity.…”

Section: Discussionmentioning

confidence: 99%

Clinicopathological Features, Risk Factors and Predispositions, and Response to Treatment of Eosinophilic Oral Disease in 24 Dogs (2000-2016)

et al. 2019

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The objectives of this study were to retrospectively describe clinicopathological features of eosinophilic oral disease in dogs, to identify possible risk factors or predispositions to the condition, and to report overall treatment response. Canine medical records from a veterinary teaching hospital and private referral practice over a 17-year period were reviewed for a diagnosis of eosinophilic oral disease. Twenty-four dogs with 26 lesions met the inclusion criteria. Patient mean age and body weight were 6.8 (3.8) years and 13.4 kg, respectively. Fifteen breeds were represented including Cavalier King Charles spaniel (16.7%), Labrador retriever (12.5%), and West Highland white terrier (12.5%). Eosinophilic lesions were found in the palate (65.4%), tongue (26.9%), and other oral locations (7.7%). Median follow-up time was 5 months. Analysis revealed statistically significant associations between lesion location and body weight (palatal and tongue lesions were more likely in smaller dogs, whereas lesions in the other category [lip or mucosa] were more likely in larger dogs). There was a correlation in lesion location and resolution (all dogs with palatal lesions became asymptomatic at their last recheck), and resolution and the use of antibiotics plus prednisone (greater likelihood of resolution without the use of this combination). Seventy percent of asymptomatic dogs resolved without medication or with allergen therapy alone, suggesting that asymptomatic dogs may respond well to conservative management. No associations were found between lesion location and breed, signalment and response to therapy, lesion resolution and the use of glucocorticoids, or significance of peripheral eosinophilia.

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Section: Discussionmentioning

confidence: 99%

Clinicopathological Features, Risk Factors and Predispositions, and Response to Treatment of Eosinophilic Oral Disease in 24 Dogs (2000-2016)

et al. 2019

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“…Clinical signs include peracute development of papules, pustules and crusts affecting face, pinnae and in particular the muzzle/bridge of the nose, hence the term “face rot.” Rarely, the abdomen or chest may also be affected and the condition can be painful or pruritic with localized swelling, ulceration, haemorrhage and fever. Permanent scarring is possible …”

Section: Insect Bite Hypersensitivitymentioning

confidence: 99%

“…Diagnosis is achieved through history, clinical examination, cytology and histology. Differential diagnoses include bacterial pyoderma or demodicosis . Many patients also have eosinophilia, and in one study, 50% of cases also had gastrointestinal symptoms …”

Section: Insect Bite Hypersensitivitymentioning

confidence: 99%

EAACIposition paper: Comparing insect hypersensitivity induced by bite, sting, inhalation or ingestion in human beings and animals

Pali‐Schöll

Blank

Verhoeckx

et al. 2019

Allergy

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Adverse reactions to insects occur in both human and veterinary patients. Systematic comparison may lead to improved recommendations for prevention and treatment in all species. In this position paper, we summarize the current knowledge on insect allergy induced via stings, bites, inhalation or ingestion, and compare reactions in companion animals to those in people. With few exceptions, the situation in human insect allergy is better documented than in animals. We focus on a review of recent literature and give overviews of the epidemiology and clinical signs.We discuss allergen sources and allergenic molecules to the extent described, and aspects of diagnosis, prophylaxis, management and therapy. K E Y W O R D S allergenic molecules in insects, comparative, insect bite hypersensitivity, insect food allergy, insect venom allergy Abbreviations: BAT, basophil activation test; CCD, cross-reactive carbohydrate determinant; CRD, component-resolved diagnosis; DBPCFC, double-blind placebo-controlled food challenge; FBH, flea bite hypersensitivity; HDM, house dust mite; IBH, insect bite hypersensitivity; IGR, insect growth regulator; LLR, large local reaction; MBH, mosquito bite hypersensitivity; RAST, radioallergosorbent test; VIT, venom immunotherapy.

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“…For example, Olivry et al (11) reported that the skin infiltrate of canine atopic dermatitis consists of mast cells, dendritic cells, memory helper T lymphocytes, neutrophils, and eosinophils. Furthermore, Curtis et al (12) reported that the eosinophil is the predominant cell type in several cases of folliculitis and furunculosis. Recently, it was reported that IL-5 mRNA could be detected in skin biopsy homogenates from dogs with atopic dermatitis.…”

Section: Introductionmentioning

confidence: 97%

Canine Interleukin-5: Molecular Characterization of the Gene and Expression of Biologically Active Recombinant Protein

Yang

Sellins

Weber

et al. 2001

Journal of Interferon & Cytokine Research

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Interleukin-5 (IL-5), which is produced primarily by type 2 T helper lymphocytes (Th2), is an eosinophil differentiation and activation factor. Increased numbers of eosinophils in peripherial blood or tissues (eosinophilia) are observed in asthmatic human patients, in animals with helminth infections, and in dogs with allergic diseases. Antagonism of IL-5 activity is being explored as a potential treatment of a number of disease conditions associated with eosinophils in animal models. In order to study the expression and function of this cytokine in the dog, we have isolated and characterized the canine IL-5 gene. The canine IL-5 polypeptide deduced from the cDNA is composed of 134 amino acids that share varying degrees of homology with IL-5 isolated from several mammals. The genomic structure of the canine IL-5 gene consists of four exons and three introns in the coding region, similar to that of the previously characterized human and mouse IL-5 genes. Recombinant canine IL-5 protein, expressed in Pichia pastoris, is biologically active in a cell proliferation assay. Canine IL-5 gene sequences and the biologically active protein described in this study will be useful reagents for future studies of this cytokine in physiologic processes and in pathologic conditions of the dog.

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Canine eosinophilic folliculitis and furunculosis in three cases

Cited by 13 publications

References 4 publications

Clinicopathological Features, Risk Factors and Predispositions, and Response to Treatment of Eosinophilic Oral Disease in 24 Dogs (2000-2016)

Clinicopathological Features, Risk Factors and Predispositions, and Response to Treatment of Eosinophilic Oral Disease in 24 Dogs (2000-2016)

EAACIposition paper: Comparing insect hypersensitivity induced by bite, sting, inhalation or ingestion in human beings and animals

Canine Interleukin-5: Molecular Characterization of the Gene and Expression of Biologically Active Recombinant Protein

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