Canine eosinophilic granuloma of the digits treated with prednisolone and chlorambucil

Abstract

Although CEG appears to be an uncommon disease, it should be included as a differential diagnosis for dermal, nodular lesions affecting the digits. Chlorambucil appears to be an effective and well tolerated prednisolone sparing agent for treatment of CEG. Carbon dioxide laser ablation appears to be an effective method of debulking CEGs.

Unilateral eosinophilic cellulitis leading to implant extrusion after bilateral enucleation in a dog

“… 17 , 18 Canine eosinophilic dermatitis shares some histopathologic but not clinical features with the lesion noted in this dog, while canine and human eosinophilic granulomas share clinical features but differ histologically. 19 , 20 , 21 , 22 , 23 …”

“…17,18 Canine eosinophilic dermatitis shares some histopathologic but not clinical features with the lesion noted in this dog, while canine and human eosinophilic granulomas share clinical features but differ histologically. [19][20][21][22][23] Clinical and histopathologic findings in the dog of this report suggest several potential alternative mechanisms for the massive eosinophilic inflammatory response seen. Eosinophils have conventionally been linked with Th2-type immune responses, produced primarily in the context of parasitic infections or allergy.…”

Eosinophilic Granuloma Treated with Prednisolone and Azathioprine in a Dog

“…Therapeutic drugs may include glucocorticoids, antihistamines, or other hyposensitization therapies (7). Other treatments yielding various results include CO 2 laser therapy and surgical incision (6). In this case, several treatments were conducted with anti-inflammatory therapy and surgical removal before referral.…”

“…Several choices to control CEG have been reported, including glucocorticoid with prednisolone sparing drugs, particularly for chlorambucil and azathioprine (7,11,12). Chlorambucil is a cell cycle nonspecific alkylating antineoplastic and immunosuppressive agent (6). It targets B-cells and is considered a slow-acting agent that may require two weeks to reach therapeutic efficacy (14).…”

“…Canine eosinophilic granuloma (CEG) is an uncommon skin disease. Skin lesions are most frequently located in the oral cavity and infrequently involve other cutaneous sites, such as the nasal planum, ventral abdomen, thorax, metatarsus, prepuce, flank, digit, eyelid, external ear canal, and cheek region (6,9,13). The common clinical types of skin manifestations are papular, nodular, or plaque lesions.…”