Canine oral squamous cell carcinoma as a spontaneous, translational model for radiation and immunology research

Boss, Mary‐Keara; Gold, Alexandra K.; Karam, Sana D.; Regan, Daniel

doi:10.3389/fonc.2022.1033704

Cited by 5 publications

(4 citation statements)

References 86 publications

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“…Our study found a higher occurrence of OSCC in mixed breed dogs, although it was also present in various pure breeds, including Poodles, Labrador Retrievers, Beagles, Boxers, Border Collies, Siberian Huskies, Pekingese, Pinschers, and Yorkshire Terriers. Despite the limited sample size, the prevalence of oral cancers in mixed breeds has also been reported in other studies of dogs [14,40]. Contrary to what is generally reported in the literature [3], our study noted that OSCC affected purebred dogs of all sizes, from minor to medium and large.…”

Section: Discussionsupporting

confidence: 52%

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Investigating Cox-2 and EGFR as Biomarkers in Canine Oral Squamous Cell Carcinoma: Implications for Diagnosis and Therapy

Files,

Santos,

Queiroga

et al. 2024

CIMB

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Oral squamous cell carcinoma (OSCC) is a common and highly aggressive dog tumor known for its local invasiveness and metastatic potential. Understanding the molecular mechanisms driving the development and progression of OSCC is crucial for improving diagnostic and therapeutic strategies. Additionally, spontaneous oral squamous cell carcinomas in dogs are an excellent model for studying human counterparts. In this study, we aimed to investigate the significance of two key molecular components, Cox-2 and EGFR, in canine OSCC. We examined 34 tumor sections from various dog breeds to assess the immunoexpression of Cox-2 and EGFR. Our findings revealed that Cox-2 was highly expressed in 70.6% of cases, while EGFR overexpression was observed in 44.1%. Cox-2 overexpression showed association with histological grade of malignancy (HGM) (p = 0.006) and EGFR with vascular invasion (p = 0.006). COX-2 and EGFR concurrent expression was associated with HGM (p = 0.002), as well as with the presence of vascular invasion (p = 0.002). These data suggest that Cox-2 and EGFR could be promising biomarkers and potential therapeutic targets, opening avenues for developing novel treatment strategies for dogs affected by OSCC. Further studies are warranted to delve deeper into these findings and translate them into clinical practice.

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Section: Discussionsupporting

confidence: 52%

“…In dogs, there is no concrete evidence linking oral SCC in dogs with tobacco smoke exposure. Consequently, dogs are being considered as a comparative model for researching OSCCs not linked to alcohol and tobacco, which are about 10-15% of the total OSCC cases in humans [14].…”

Section: Introductionmentioning

confidence: 99%

Investigating Cox-2 and EGFR as Biomarkers in Canine Oral Squamous Cell Carcinoma: Implications for Diagnosis and Therapy

Files,

Santos,

Queiroga

et al. 2024

CIMB

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“…In the present study, the median age of dogs diagnosed with oral SCC was about 11 years, with a higher occurrence in males than females. The general treatment protocol for patients with oral SCC involves either chemoradiation or aggressive surgical removal of the tumor, followed by radiation therapy (RT) with or without chemotherapy [ 24 ]. Interestingly, a recent study has indicated that combining RT with immunotherapy may lead to improved response rates in dogs, similar to findings observed in humans [ 25 ].…”

Section: Discussionmentioning

confidence: 99%

Characteristics of canine oral tumors: Insights into prevalence, types, and lesion distribution

Satthathum,

Srisampane,

Jariyarangsrirattana

et al. 2023

J Adv Vet Anim Res

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Objective: The escalating prevalence of canine oral tumors has emerged as a considerable health concern. This study examined the prevalence, types, and distributions of lesions linked to canine oral tumors. Material and Methods: The medical records of 526 dogs diagnosed with oral tumors were analyzed to determine the prevalence, types, and distributions. Tumor stages were classified into four categories using the tumor node metastasis system. Results: Among the 526 dogs, there were 118 cases of benign tumors and 408 cases of malignant tumors. Acanthomatous ameloblastoma was the most common benign tumor (43.22%), while melanoma was the most common malignant tumor (51.23%). The gingiva was the most common site for both benign and malignant lesions, accounting for 89.83% and 63.73% of cases, respectively. Melanoma, squamous cell carcinoma, and fibrosarcoma were primarily located in the gin¬giva, whereas osteosarcoma was commonly found in the mandible. Most tumors were classified as stage III (ranging from 46.84% to 74.58%). Of the reported cases, 56.08% were males and 43.92% were females, and the most common breed was mixed at 30.41%, followed by Poodle at 14.25% and Shih Tzu at 11.40%. Moreover, patients with malignant oral tumors (11.6 ± 3.1 years) were significantly older than those with benign tumors (8.9 ± 3.4 years, p < 0.0001). Conclusion: Gingiva was the primary site for oral tumors, and mainly classified as stage III. These findings emphasize the increasing occurrence of oral tumors in senior and geriatric dogs and provide insights into the prevalent types and distribution.

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“…CSU has also recently studied the immune landscape of canine oral squamous cell carcinoma to combine radiation therapy and immunotherapy in canines. Future studies may contribute to developing novel therapies in human patients [ 51 ].…”

Section: Future Research Contributions From Companion Animals and Vet...mentioning

confidence: 99%

Companion Animals as a Key to Success for Translating Radiation Therapy Research into the Clinic

Vanhaezebrouck

Scarpelli

2023

Cancers

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Many successful preclinical findings fail to be replicated during translation to human studies. This leads to significant resources being spent on large clinical trials, and in some cases, promising therapeutics not being pursued due to the high costs of clinical translation. These translational failures emphasize the need for improved preclinical models of human cancer so that there is a higher probability of successful clinical translation. Companion-animal cancers offer a potential solution. These cancers are more similar to human cancer than other preclinical models, with a natural evolution over time, genetic alterations, intact immune system, and a permanent adaptation to the microenvironment. These advantages have led pioneers in veterinary radiation oncology to aid human medicine by elucidating basic principles of radiation biology. More recently, the veterinary and human radiation oncology fields have increasingly collaborated to achieve advancements in education, radiotherapy techniques, and trial networks. This review describes these advancements, including significant prior research findings and the evolution of the veterinary radiation oncology discipline. It concludes by describing how companion-animal models can help shape the future of human radiotherapy. Taken as a whole, this review suggests companion-animal cancers may become widely used for preclinical radiotherapy research.

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Canine oral squamous cell carcinoma as a spontaneous, translational model for radiation and immunology research

Cited by 5 publications

References 86 publications

Investigating Cox-2 and EGFR as Biomarkers in Canine Oral Squamous Cell Carcinoma: Implications for Diagnosis and Therapy

Investigating Cox-2 and EGFR as Biomarkers in Canine Oral Squamous Cell Carcinoma: Implications for Diagnosis and Therapy

Characteristics of canine oral tumors: Insights into prevalence, types, and lesion distribution

Companion Animals as a Key to Success for Translating Radiation Therapy Research into the Clinic

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