Canine Parvovirus: Current Perspective

Nandi, Sukdeb; Kumar, Manoj

doi:10.1007/s13337-010-0007-y

Cited by 107 publications

(122 citation statements)

References 64 publications

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“…In fact, some owners described convulsions and respiratory distress, as one of the main complaints, along with diarrhea. These events may be correlated with hypovolemic, endotoxic and septicemic shock (Prittie 2004, Goddard & Leisewitz 2010), yet they seem not exclusive of CPV-2c infected dogs (Nandi & Kumar 2010). These signs have been also observed in the cardiac syndrome or myocarditis associated with parvovirus infection of puppies (Carpenter et al 1980), but are rare in dogs presenting hemorrhagic gastroenteric disease.…”

Section: Resultsmentioning

confidence: 99%

“…This variant was subsequently shown to affect adult and immunized dogs, and also cats (Buonavoglia et al 2001, Decaro & Buonavoglia 2012, Miranda et al 2014, quickly spread out and became established in dog populations throughout the world (Cotmore & Tattersall 1996, Buonavoglia et al 2001, Pérez et al 2007, Streck et al 2009, Nandi & Kumar 2010, Parthiban et al 2010. Up to the present, the CPV-2c variant has been detected in high frequencies in many countries.…”

Section: Introductionmentioning

confidence: 99%

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Epidemiological, clinical and pathological features of canine parvovirus 2c infection in dogs from southern Brazil

et al. 2018

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Canine parvovirus type 2c (CPV-2c) emerged in Europe in the early 2000’s and rapidly spread out worldwide. Clinical and molecular data have demonstrated its circulation in Brazilian dogs, yet detailed descriptions of cases are still lacking. This article describes the epidemiological, clinical and pathological features of 24 cases of CPV-2c-associated disease in dogs submitted to veterinary clinics and laboratory diagnosis in southern Brazil (2014-2016). Most affected dogs presented signs/lesions suggestive of parvovirus enteritis: diarrhea, vomiting, hyperemia and hemorrhage of the serous membrane of the small intestine, diffuse segmental granulation, atrophy of the villi, necrosis and fusion of crypts, squamous metaplasia and epithelial syncytia. A number of cases presented features divergent from the classical presentations, including a wide variation in the color of feces (reddish and/or yellowish, light-brownish, orange-brown and brownish), involvement of adults (4/24) and vaccinated dogs (12/24), extensive involvement of the small intestine (8/20) and the presence of pulmonary edema (7/24) and convulsions (3/24). Feces and intestinal fragments submitted to PCR for the CPV-2 VP2 gene and to virus isolation in cell culture yielded positive results in 100% and 58.3% (14/24) of the cases, respectively. Nucleotide sequencing revealed a high nucleotide identity in VP2 (99.4 to 100%) and a consistent mutation at amino acid 426 (asparagine to glutamic acid), considered a signature of CPV-2c. These results confirm the involvement of CPV-2c in the described cases and demonstrate the importance of CPV-2c infection among Brazilian dogs, calling attention of veterinarians to correctly diagnose the disease, mainly considering the frequent atypical presentations.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Epidemiological, clinical and pathological features of canine parvovirus 2c infection in dogs from southern Brazil

et al. 2018

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“…This might be related to environmental loading of viral particles during consecutive months of dry weather. A single infected dog can shed 35,000 times the infectious dose per ounce of faeces (Nandi and Kumar, 2010). Since canine parvovirus is nonenveloped, outdoor areas can remain contaminated with viral particles for up to 7 months (Nandi and Kumar, 2010).…”

Section: Discussionmentioning

confidence: 99%

The relationship between the Southern Oscillation Index, rainfall and the occurrence of canine tick paralysis, feline tick paralysis and canine parvovirus in Australia

Rika-Heke

Kelman²,

Ward

2015

The Veterinary Journal

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“…CPV is a highly contagious virus and it causes often fatal diseases (Nandi and Kumar 2010). CPV, a member of the Parvoviridae family Protoparvovirus genus, contains a single strand DNA genome of about 5200 nucleotides that is packaged in an icosahedral capsid (Siegl et al 1985, Cotmore et al 2014).…”

Section: Introductionmentioning

confidence: 99%

Phylogenetic characterization of Canine Parvovirus VP2 partial sequences from symptomatic dogs samples

Zienius¹,

Lelešius²,

Kavaliauskis³

et al. 2016

Polish Journal of Veterinary Sciences

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The aim of the present study was to detect canine parvovirus (CPV) from faecal samples of clinically ill domestic dogs by polymerase chain reaction (PCR) followed by VP2 gene partial sequencing and molecular characterization of circulating strains in Lithuania.Eleven clinically and antigen-tested positive dog faecal samples, collected during the period of 2014-2015, were investigated by using PCR. The phylogenetic investigations indicated that the Lithuanian CPV VP2 partial sequences (3025-3706 cds) were closely related and showed 99.0-99.9% identity. All Lithuanian sequences were associated with one phylogroup, but grouped in different clusters. Ten of investigated Lithuanian CPV VP2 sequences were closely associated with CPV 2a antigenic variant (99.4% nt identity). Five CPV VP2 sequences from Lithuania were related to CPV-2a, but were rather divergent (6.8 nt differences). Only one CPV VP2 sequence from Lithuania was associated (99.3% nt identity) with CPV-2b VP2 sequences from France, Italy, USA and Korea. The four of eleven investigated Lithuanian dogs with CPV infection symptoms were vaccinated with CPV-2 vaccine, but their VP2 sequences were phylogenetically distantly associated with CPV vaccine strains VP2 sequences (11.5-15.8 nt differences).Ten Lithuanian CPV VP2 sequences had monophyletic relations among the close geographically associated samples, but five of them were rather divergent (1.0% less sequence similarity). The one Lithuanian CPV VP2 sequence was closely related with CPV-2b antigenic variant. All the Lithuanian CPV VP2 partial sequences were conservative and phylogenetically low associated with most commonly used CPV vaccine strains.

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Canine Parvovirus: Current Perspective

Cited by 107 publications

References 64 publications

Epidemiological, clinical and pathological features of canine parvovirus 2c infection in dogs from southern Brazil

Epidemiological, clinical and pathological features of canine parvovirus 2c infection in dogs from southern Brazil

The relationship between the Southern Oscillation Index, rainfall and the occurrence of canine tick paralysis, feline tick paralysis and canine parvovirus in Australia

Phylogenetic characterization of Canine Parvovirus VP2 partial sequences from symptomatic dogs samples

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