Canine parvovirus type 2 vaccine protects against virulent challenge with type 2c virus

Comparative molecular analysis of strains of the Aleutian Disease Virus isolated from farmed and wild mink

“…Single changes in the amino acid sequence may be of key importance for pathogenicity; it is theorized that nonsynonymous changes in the gene encoding VP2 in FPLV led to the emergence of CPV-2 [20]. Substitutions in this protein led to the separation of variants a, b and c, which supplanted the original strain; a change in just one amino acid enables differentiation of the pathogen into variants a and b [21].…”

A phylogenetic study of canine parvovirus type 2c in midwestern Brazil

“…In addition, Decaro et al (2005b) have demonstrated in German shepherds dogs naturally infected with a field isolate of CPV-2c, that pups displayed clinical signs of parvovirosis (mucoid or watery diarrhea and transient leukopenia), however none showed either hemorrhagic diarrhea or vomiting. On the other hand, Spibey et al (2008) carried out an experimental infection of beagles dogs with a field isolate of CPV-2c that all infected control dogs became severely ill and displayed leukopenia from day 4 post-infection. Although the necropsied animals of this study showed severe macroscopic and microscopic intestinal lesions, the authors cannot suggest that CPV-2c could be associated with more severe disease than CPV-2a and CPV-2b due to the low number of samples analyzed.…”

Canine Parvovirus: Current Perspective

“…The emergence of the 2c variant naturally raises the question of whether the CPV-2 vaccines can provide protection against this new variant also. The research to date also showed that all currently available vaccines based on CPV-2 and CPV-2b protect against all known strains of CPV, including the newer CPV-2c strain [81,85]. In India, most of the vaccines marketed are based on the CPV-2 isolated about 30 years ago [57,61].…”