Canine T-cell Lymphomas: A Morphological, Immunological, and Clinical Study of 46 New Cases

Fournel‐Fleury, C.; Ponce, Frédérique; Felman, Pascale; Blavier, Adelaïde; Bonnefont, Cécile; Chabanne, Luc; Marchal, Thierry; Cadoré, Jean‐Luc; Goy‐Thollot, Isabelle; Ledieu, D.; Ghernati, I.; Magnol, J. P.

doi:10.1354/vp.39-1-92

Cited by 152 publications

(260 citation statements)

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“…The CD3 is a speciϐic marker for T lymphocytes (Fournel-Fleury et al 2002). In this study, 92% (34/37) of the CLs were positive for CD3.…”

Section: Discussionsupporting

confidence: 53%

“…Similar to what occurs in humans, the determination of the immunophenotype of lymphoma in dogs has become essential because of the relationship to biological behavior and response to therapy (Fontaine et al 2010, Fournel-Fleury et al 2002. Currently, the immunohistochemical markers most commonly used to characterize T and B lymphocytes in formalin--ϐixed, parafϐin-embedded tissues include CD3 (Fournel--Fleury et al 2002) and CD79a (Milner et al 1996), respectively.…”

Section: Introductionmentioning

confidence: 99%

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Histomorphological and immunohistochemical characterization of 172 cutaneous round cell tumours in dogs

Araújo

Preis

Lavalle³

et al. 2012

Pesq. Vet. Bras.

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Pesq. Vet. , cytokeratin, vimentin and E-cadherin) on formalin-ϐixed, parafϐin-embedded sections of canine cutaneous round cell tumours. Neoplastic tumours were diagnosed by histology and histochemical stains and included 107 mast cell tumours, 31 cutaneous histiocytomas, two localized histiocytic sarcomas, 21 cutaneous lymphomas, three plasma cell tumours, one transmissible venereal tumour and seven unclassiϐied round cell tumours. The histologic diagnosis was modiϐied in 39.5% of the total 172 neoplasms. The staining for CD45 and Ecadherin were variable, and therefore, the ϐinal diagnoses of cutaneous histiocytoma and localized histiocytic sarcoma were made based on histology in association with negative results for CD3, CD79a, CD117 and cytokeratin. The cellular origin of unclassiϐied round cell tumours was deϐined in all cases. Cutaneous B-cell lymphoma and plasma cell tumours were CD79a-positive and could be distinguished from each other by the morphological characteristics. Mast cell tumours and T cell lymphoma were CD117 and CD3 positive, respectively. The positive staining for vimentin and the negative staining for CD3, CD79a, CD117 and cytokeratin favoured the diagnosis of transmissible venereal tumours. Thus, the ϐinal diagnosis of cutaneous round cell tumours should be based on the interpretation of immunohistochemical results together with the cellular morphology observed by histology. Therefore, more studies to optimize the speciϐic markers in formalin-ϐixed, parafϐin-embedded tissues (especially for histiocytes) are required for deϐinitive diagnosis of round cell tumours in dogs. las redondas em cães. Os tumores foram diagnosticados usando-se a histopatologia e a marcação imuno-histoquí-mica. Foram incluídos 107 mastocitomas, 31 histiocitomas cutâneos, 2 sarcomas histiocíticos localizados, 21 linfomas cutâneos, 3 plasmocitomas, 1 tumor venéreo transmissí-vel e 7 tumores de células redondas não classiϐicados. O diagnóstico histológico foi modiϐicado em 39,5% do total de 172 neoplasias. A marcação do anticorpo CD45 e E--caderina foi variável e, nesse sentido, o diagnóstico ϐinal de histiocitoma cutâneo e sarcoma histiocítico localizado foi baseado na histologia em associação com os resultados negativos para CD3, CD79a, CD117 e citoqueratina. A origem celular dos tumores de células redondas não classiϐicados foi deϐinida em todos os casos. foram distinguidos entre si pelas características morfológi-cas. Marcação positiva para vimentina e negativa para CD3, CD79a, CD117 e citoqueratina favoreceram o diagnóstico dos tumores venereos transmissíveis. Assim, o diagnósti-co ϐinal dos tumores de células redondas foram baseados na interpretação dos resultados da imuno-histoquímica em conjunto com a avaliação das características morfoló-gicas observadas na histologia. Finalmente, mais estudos em relação à padronização de marcadores especíϐicos para tecidos paraϐinizados (especialmente para histiócitos) são necessários para o diagnóstico deϐinitivo das neoplasias de células redondas em cães.TERMOS DE INDEXAÇÃO...

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“…The CD3 is a speciϐic marker for T lymphocytes (Fournel-Fleury et al 2002). In this study, 92% (34/37) of the CLs were positive for CD3.…”

Section: Discussionsupporting

confidence: 53%

Section: Introductionmentioning

confidence: 99%

Histomorphological and immunohistochemical characterization of 172 cutaneous round cell tumours in dogs

Araújo

Preis

Lavalle³

et al. 2012

Pesq. Vet. Bras.

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“…T‐cell lymphoma (TCL) accounts for approximately 10‐38% of canine non‐Hodgkin's lymphoma (LSA) 1, 2. The disease is considered to have a more aggressive clinical course and is associated with a poorer prognosis (6–9 months median survival) when compared to B‐cell lymphoma (BCL; 12–14 months median survival) 3…”

mentioning

confidence: 99%

Autologous Peripheral Blood Hematopoietic Cell Transplantation in Dogs with T‐Cell Lymphoma

Warry

Willcox

Suter

2014

Veterinary Internal Medicne

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BackgroundPeripheral blood hematopoietic cell transplantation (PBHCT) is a feasible treatment option for dogs with B‐cell lymphoma.ObjectiveTo examine apheresis and PBHCT outcomes in dogs diagnosed with T‐cell lymphoma (TCL).AnimalsFifteen client‐owned dogs diagnosed with high‐grade TCL.MethodsAfter high‐dose cyclophosphamide and rhG‐colony‐stimulating (rhG‐CSF) factor treatment, peripheral blood mononuclear cells were collected using cell separators. The harvested cells then were infused after varying doses of total body irradiation (TBI). Postirradiation adverse effects were managed symptomatically and dogs were discharged upon evidence of hematopoietic engraftment.ResultsMore than 2 × 106 CD34+ cells/kg were harvested from 15/15 dogs. Thirteen of 15 (87%) dogs engrafted appropriately, whereas 2 (13%) of the dogs died in the hospital. One dog developed cutaneous B‐cell lymphoma 120 days post‐PBHCT. The median disease‐free interval and overall survival (OS) of the 13 dogs transplanted in first remission from the time of PBHCT were 184 and 240 days, respectively. Stage and substage of disease at diagnosis had no effect on OS. Two of 13 (15%) dogs were alive 741 and 772 days post‐PBHCT.Conclusions and Clinical Importance PBHCT may be considered as a treatment option for dogs with TCL.

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“…In veterinary clinical science, some studies indicate that the updated Kiel classification is applicable to canine lymphomas [6,7,17,19,22]. One of the studies reported that the first remission duration and the overall survival time were significantly different among the subtypes of lymphomas [17].…”

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confidence: 99%

Cytomorphological and Immunological Classification of Feline Lymphomas: Clinicopathological Features of 76 Cases

Chino

Fujino

Kobayashi

et al. 2013

The Journal of Veterinary Medical Science

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ABSTRACT. Of the various classification systems for non-Hodgkin's lymphoma, the updated Kiel classification is valuable for veterinary practice, because of its utility to classify the subtypes not only by histopathology but also by cytomorphology. However, there are only a few reports of small number of feline lymphomas to apply the updated Kiel classification. In this study, immunogical subtypes and morphology of 76 feline lymphomas were evaluated and classified into subtypes of the updated Kiel classification. Of the cases, 49% were T-cell lymphoma, 25% were B-cell lymphoma and 26% were undetermined immunological subtype. Based on the updated Kiel classification, most subtypes were identified also in feline lymphomas as in dogs and humans. Globule leukocyte lymphoma was specific for cats and relatively common in feline alimentary lymphomas. Of the present cases, 64% were high-grade subtypes, whereas 36% were low-grade subtypes. The present study indicated that feline lymphomas could be morphologically classified by the modified updated Kiel classification.

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Canine T-cell Lymphomas: A Morphological, Immunological, and Clinical Study of 46 New Cases

Cited by 152 publications

References 71 publications

Histomorphological and immunohistochemical characterization of 172 cutaneous round cell tumours in dogs

Histomorphological and immunohistochemical characterization of 172 cutaneous round cell tumours in dogs

Autologous Peripheral Blood Hematopoietic Cell Transplantation in Dogs with T‐Cell Lymphoma

Cytomorphological and Immunological Classification of Feline Lymphomas: Clinicopathological Features of 76 Cases

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