Cytomorphological and Immunological Classification of Feline Lymphomas: Clinicopathological Features of 76 Cases

Chino, Junko; Fujino, Yasuhito; Kobayashi, Tetsuya; Kariya, Kazuhiro; Goto‐Koshino, Yuko; Ohno, Koichi; Nakayama, Hiroyuki; Tsujimoto, Hajime

doi:10.1292/jvms.12-0246

Cited by 32 publications

(40 citation statements)

References 22 publications

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“…From these cases, samples for cytology and/or histopathology were obtained and evaluated. Of the cases, 76 cats described previously [1] were also included in the present prognostic study.…”

Section: Methodsmentioning

confidence: 99%

“…In those studies, cytomorphology was found to be of prognostic importance for overall survival time in dogs with lymphoma. However, there has been no study investigating the prognostic significance of cytomorphology of feline lymphoma, since it has been reported that morphological classification is applicable to feline lymphoma [1]. Moreover, studies comparing outcomes of each anatomical form of lymphoma have been poorly reported.…”

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confidence: 99%

“…The aim of the present study was to evaluate whether the outcome of feline lymphoma is associated with anatomical status and cytomorphological grades according to the established classification of feline lymphoma [1]. The hypotheses of the present study were considered from practical experiences in cats and previous research of other species showing that alimentary lymphoma and high-grade lymphomas in cats could indicate poorer outcome.…”

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confidence: 99%

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Prognostic Analyses on Anatomical and Morphological Classification of Feline Lymphoma

et al. 2014

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The present study was carried out to analyze the prognosis of 163 cats with lymphoma classified anatomically and cytomorphologically. Anatomically, alimentary lymphoma was the most common form and showed significantly shorter survival than mediastinal and nasal lymphomas in cats. Cytomorphologically, there was no predominant subtype in feline lymphomas. Immunoblastic type (18%), centroblastic type (16%), globule leukocyte type (15%), lymphocytic type (12%), lymphoblastic type (12%), pleomorphic medium and large cell type (10%) and anaplastic large cell type (7%) were relatively common subtypes. Most of the cats with globule leukocyte lymphoma had the alimentary form. Comparing median survival time among classifications, cats with globule leukocyte lymphoma showed significantly shorter survival than those with high-grade and other low-grade lymphomas. Furthermore, cats with high-grade lymphomas showed significantly shorter survival than cats with other low-grade lymphomas. The present study indicated the clinical significance of anatomical and cytomorphological evaluation in feline lymphomas.

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Section: Methodsmentioning

confidence: 99%

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Prognostic Analyses on Anatomical and Morphological Classification of Feline Lymphoma

et al. 2014

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“…Large granular lymphomas (LGLs) comprise a specific group of lymphomas regardless of classification scheme. An LGL consists of cells that show less or study LGLs comprised more than 14% of all lymphomas recognized in cats, making LGL a quite common problem in feline oncology (Chino et al 2013). Among other felids lymphoma composed of large granular lymphocytes involving ocular structures was also described in a caracal (Caracal caracal;Aitken-Palmer et al 2011).…”

Section: Introductionmentioning

confidence: 99%

Large granular lymphoma in six cats

Sapierzyński¹,

Jankowska²,

Jagielski³

et al. 2015

Polish Journal of Veterinary Sciences

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Large granular lymphomas (LGLs) comprise a specific group of lymphomas regardless of classification scheme. An LGL consists of cells that show less or more mature morphology, but typically neoplastic cells possess cytoplasmic azurophilic granules clearly visible during cytological examination. The aim of the present study was to present clinical and cytological data on large granular lymphomas in cats and to analyses the therapeutic responses in treated cases. During the period from 2012 to 2014 six cats were as having large granular lymphoma. In one cat a nasal form of LGL was recognized, a systemic form was recognized in another cat, and in four cases an alimentary form was recognized. Cellular samples for cytopathology were collected from the cat with nasal cavity mass, from the enlarged mandibular lymph node and thoracic cavity from second cat, and in four cats from the abdominal mass during ultrasound-assisted fine-needle biopsy. Therapy was introduced in 5 of the 6 cats. In two cases palliative therapy with glucocorticoids was conducted, in two cases chemotherapy with COP protocol, and therapy with masitinib in one case. The median of survival time for cats treated with anticancer therapy was 9 months, the median of survival time for cats treated with glucocorticoids was 1.5 months. In conclusion, large granular lymphomas, especially the alimentary form, are a relatively common type of lymphoma in cats. Simple diagnostic methods such as clinical examination, imaging techniques and routine cytology are sufficient in majority of cases. Despite aggressive behavior and poor general prognosis, conventional chemotherapy lead to a good response in some treated cats regardless of anatomic form and histologic grade of malignancy.

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“…In cats, the diagnosis is more challenging because lymphoma more commonly affects extranodal sites, particularly the alimentary and upper respiratory tract. 3,4 Lymphoma affecting the gastrointestinal tract is common but particularly challenging to diagnose, owing to the relative inaccessibility for sampling and potential progression from lymphocytic inflammation to neoplasia. Other types of lymphoma in cats often contain a heterogeneous population of neoplastic lymphocytes plus reactive lymphocytes, plasma cells, and other inflammatory cells.…”

Section: Introductionmentioning

confidence: 99%