2012
DOI: 10.1177/0269881112460109
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Cannabidiol inhibits THC-elicited paranoid symptoms and hippocampal-dependent memory impairment

Abstract: Community-based studies suggest that cannabis products that are high in Δ⁹-tetrahydrocannabinol (THC) but low in cannabidiol (CBD) are particularly hazardous for mental health. Laboratory-based studies are ideal for clarifying this issue because THC and CBD can be administered in pure form, under controlled conditions. In a between-subjects design, we tested the hypothesis that pre-treatment with CBD inhibited THC-elicited psychosis and cognitive impairment. Healthy participants were randomised to receive oral… Show more

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Cited by 414 publications
(377 citation statements)
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“…Mean peak plasma concentrations of CBD (77.9 ng/ml) following administration of CBD (800 mg) exceeded those from studies demonstrating a significant CBD effect on mood or fMRI activation. For instance, peak plasma concentrations following administration of CBD (600 mg) administration ranged from 17.0 ng/ml (Winton-Brown et al, 2011 ;Bhattacharyya et al, 2010, Borgwardt et al, 2008Fusar-Poli et al, 2009) to about 55 ng/ml (Englund et al, 2013). Although cannabis effects peaked 120 min after CBD administration in the current study, and 60 min earlier than peak CBD concentrations, there was no indication that CBD attenuated cannabis effects at any point during the 2-h cannabis time course (Figures 1 and 2); note, we did not assess whether CBD altered the metabolism of THC, as there is little to suggest that this occurs in humans (Hunt et al, 1981;Englund et al, 2013;Agurell et al, 1981;Karschner et al, 2011a, b).…”
Section: Discussionmentioning
confidence: 99%
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“…Mean peak plasma concentrations of CBD (77.9 ng/ml) following administration of CBD (800 mg) exceeded those from studies demonstrating a significant CBD effect on mood or fMRI activation. For instance, peak plasma concentrations following administration of CBD (600 mg) administration ranged from 17.0 ng/ml (Winton-Brown et al, 2011 ;Bhattacharyya et al, 2010, Borgwardt et al, 2008Fusar-Poli et al, 2009) to about 55 ng/ml (Englund et al, 2013). Although cannabis effects peaked 120 min after CBD administration in the current study, and 60 min earlier than peak CBD concentrations, there was no indication that CBD attenuated cannabis effects at any point during the 2-h cannabis time course (Figures 1 and 2); note, we did not assess whether CBD altered the metabolism of THC, as there is little to suggest that this occurs in humans (Hunt et al, 1981;Englund et al, 2013;Agurell et al, 1981;Karschner et al, 2011a, b).…”
Section: Discussionmentioning
confidence: 99%
“…Preclinical and some controlled clinical studies have suggested that CBD reduces THC-related memory impairment (Zhornitsky and Potvin, 2012;Englund et al, 2013). Naturalistic smoking studies, comparing cognitive performance in individuals after they smoked their own cannabis (Morgan et al, 2010) have suggested that CBD protects against the negative cognitive effects of THC (Henquet and Kuepper, 2010).…”
Section: Discussionmentioning
confidence: 99%
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“…Several studies posited that the "entourage" of "[whole] plants are better drugs than the natural products isolated from them", suggesting that the clinical effects of cannabis usage may be due to complex interactions between several plant cannabinoids [134,135]. In support of this view, CBD may potentiate the beneficial effects associated with Δ9-THC (analgesia, antiemesis, and anti-inflammation) and reduce the negative psychoactive effects of Δ9-THC (impaired working memory, sedation, tachycardia, and paranoia) [136][137][138]. Users of cannabis with a high CBD:Δ9-THC ratio have greater tolerability and lower rates of psychosis than users of high Δ9-THC:CBD ratios (or Δ9-THC alone) [139].…”
Section: Cbdmentioning
confidence: 99%
“…Short-term use can impair short-term memory, coordination, and judgment. In high doses, paranoia and psychosis can occur [137,269]. Long-term use of recreational cannabis in adolescents is associated with addiction (9 % overall but 17 % among adolescents) and impaired cognitive and academic performance [270][271][272][273][274].…”
Section: Safety Issuesmentioning
confidence: 99%