Cannabidiol Suppresses Cytokine Storm and Protects Against Cardiac and Renal Injury Associated with Sepsis

Maayah, Zaid H.; Ferdaoussi, Mourad; Alam, Abrar S.; Takahara, Shingo; Silver, Heidi; Soni, Shubham; Martens, Matthew D.; Eurich, Dean T.; Dyck, Jason R.B.

doi:10.1089/can.2022.0170

Cited by 2 publications

(1 citation statement)

References 41 publications

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“…In the mouse model of acetone Croton oil-induced in ammatory pain and LPS-induced in ammatory pain, CBD could reduce the levels of pro-in ammatory cytokines IL-6 and TNF-α in the serum and increase the level of anti-in ammatory IL-10 [21] . CBD dissolved in corn oil enhanced LPS-induced pulmonary in ammation and increased levels of pro-in ammatory factors and granulocyte colony-stimulating factor [22] . CBD has a wide range of targets, including eCBs, G Protein Receptor 55 (GPR55), 5hydroxytryptamine 1A Receptor, dopamine Receptor, opioid Receptor, peroxisome proliferator-activated…”

Section: Introductionmentioning

confidence: 94%

Cannabidiol inhibits inflammation in rat osteoarthritis

Yin

Zhang

Chen

et al. 2023

Preprint

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(1)Objective: To investigate the therapeutic effect of cannabidiol (CBD) on osteoarthritis (OA) in rats. (2)Methods: We randomly divided 36 female SD rats with SPF values of 7 weeks into model control, CBD at elevated doses, CBD at low doses, solvent control, and PBS control. Sodium acetate OA was modeled in the model, experimental and solvent control groups. After modeling, the experimental group was injected daily with CBD and solvent, and the control group was injected with PBS. After 12 days of treatment, the OA grade was scored, and the rats were anesthetized, and the rats were sacrificed by neck dislocation, blood was collected from the heart, knee joints were collected, the degree of joint swelling was recorded, and serum inflammatory cytokines IFN-γ, IL-1β, TFN-α, IL-6 concentration were and pathological changes of knee joint. (3）Results: Compared with the model group and the solvent control group, the pain and claudication of the rats in the CBD experimental group were effectively relieved, and the levels of inflammatory cytokines (IFN-γ, IL-1β, TFN-α) in serum and synovial fluid were significantly reduced. Arthritic pathologic changes in the knee were significantly reduced. (4) Conclusion: CBD is effective in reducing blood inflammatory factors in OA rats, relieving pain and pathological changes, and has significant therapeutic effects in osteoarthritis.

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Section: Introductionmentioning

confidence: 94%

Cannabidiol inhibits inflammation in rat osteoarthritis

Yin

Zhang

Chen

et al. 2023

Preprint

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Case report: Cannabinoid therapy for discoid lupus erythematosus in a dog

da Silva,

Christianetti,

Amazonas

et al. 2024

Front. Vet. Sci.

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Discoid lupus erythematosus (DLE) is a common autoimmune skin disease in dogs. Conventional treatments, such as corticosteroids, can be effective but often have side effects. This case report presents a successful use of cannabinoid therapy (CT) in a dog with DLE resistant to conventional treatment. A 2-year-old mixed-breed dog with a history of DLE presented with worsening lesions despite treatment with corticosteroids and other medications. Liver enzymes levels were elevated, indicating corticosteroid-induced side effects. CT with a CBD-rich full spectrum Cannabis oil was initiated. The dosage was gradually adjusted until the minimum effective dose was found. Within a few weeks of starting CT, the dog showed significant improvement in skin lesions and in liver enzymes levels. After 1 year, the dog remains clinically stable on a low dose of full-spectrum CBD-rich oil. No evidence of DLE recurrence was observed. This case suggests that CT may be a viable alternative or complementary therapy for DLE in dogs, particularly for those experiencing adverse effects from conventional treatments. Further research is warranted to confirm the efficacy and safety of CT for DLE management in dogs.

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Cannabidiol Suppresses Cytokine Storm and Protects Against Cardiac and Renal Injury Associated with Sepsis

Cited by 2 publications

References 41 publications

Cannabidiol inhibits inflammation in rat osteoarthritis

Cannabidiol inhibits inflammation in rat osteoarthritis

Case report: Cannabinoid therapy for discoid lupus erythematosus in a dog

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