2009
DOI: 10.1016/j.jtcvs.2009.07.014
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Cannabinoid 1 receptor mediation of spinal cord ischemic tolerance induced by limb remote ischemia preconditioning in rats

Abstract: These results indicated that endogenous cannabinoids, through acting on cannabinoid 1 receptors, were involved in the neuroprotective phenomenon on spinal cords of limb remote ischemic preconditioning.

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Cited by 28 publications
(35 citation statements)
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“…Similarly, ischemic preconditioning acts on the primary organ and as well as remote organs, by humoral or neural pathways promoting systemic effects [15][16][17][18] .…”
Section: Discussionmentioning
confidence: 99%
“…Similarly, ischemic preconditioning acts on the primary organ and as well as remote organs, by humoral or neural pathways promoting systemic effects [15][16][17][18] .…”
Section: Discussionmentioning
confidence: 99%
“…Treatment with rimonabant improves insulin sensitivity in diet-induced obese mice (39). However, several studies have reported the CB 1 Rmediated protective effect in neurons (14,24,48,57). The pros and cons of the use of CB 1 R antagonists may be dependent upon cell and organ specificity.…”
Section: Discussionmentioning
confidence: 99%
“…Accumulating evidence indicates that synthetic or endogenous cannabinoids protect against central nervous system injury by factors including ischemic/reperfusion ( 29,30 ) and hyperglycemia ( 31 ). Although the exact mechanisms of these neuroprotective effects are not completely understood, numerous CB receptor-dependent as noids are ubiquitous lipid signaling molecules that exert a number of central and peripheral actions mediated primarily by the specifi c receptors CB1 and CB2.…”
Section: Win55212-2 Decreases Oxldl-induced Ros Generation In Macropmentioning
confidence: 99%