Cannabinoid enhancement of lncRNA MMP25-AS1/MMP25 interaction reduces neutrophil infiltration and intestinal epithelial injury in HIV/SIV infection

Premadasa, Lakmini; Lee, Eun-Hee; McDew-White, Marina; Álvarez, Xavier; Jayakumar, Sahana; Ling, Binhua; Okeoma, Chioma M.; Byrareddy, Siddappa N.; Kulkarni, S. R.; Mohan, Mahesh

doi:10.1172/jci.insight.167903

Cited by 5 publications

(1 citation statement)

References 62 publications

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“…Emerging evidence suggests the involvement of epigenetic mechanisms, particularly long non-coding RNAs (lncRNAs), in maintaining epithelial homeostasis. Premadasa et al [64] recently showed that THC enhanced the interaction between long non-coding RNA MMP25-AS1 and its associated protein coding gene MMP25. Enhancement of this interaction was associated with reduced neutrophil transendothelial/transepithelial migration in the colon in chronic HIV/SIV infection.…”

Section: Cannabis Hiv and Gut-brain Axismentioning

confidence: 99%

Therapeutic Potential of Cannabis: A Comprehensive Review of Current and Future Applications

Leinen,

Mohan,

Premadasa

et al. 2023

Biomedicines

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Historically, cannabis has been valued for its pain-relieving, anti-inflammatory, and calming properties. Ancient civilizations like the Egyptians, Greeks, and Chinese medicines recognized their therapeutic potential. The discovery of the endocannabinoid system, which interacts with cannabis phytoconstituents, has scientifically explained how cannabis affects the human immune system, including the central nervous system (CNS). This review explores the evolving world of cannabis-based treatments, spotlighting its diverse applications. By researching current research and clinical studies, we probe into how cannabinoids like Δ9-tetrahydrocannabinol (THC) and cannabidiol (CBD) help to manage conditions ranging from chronic pain, persistent inflammation, cancer, inflammatory bowel disease, and neurological disorders to even viral diseases such as Human Immunodeficiency virus (HIV), SARS-CoV-2. and the emerging monkeypox. The long-term recreational use of cannabis can develop into cannabis use disorder (CUD), and therefore, understanding the factors contributing to the development and maintenance of cannabis addiction, including genetic predisposition, neurobiological mechanisms, and environmental influences, will be timely. Shedding light on the adverse impacts of CUD underscores the importance of early intervention, effective treatment approaches, and public health initiatives to address this complex issue in an evolving landscape of cannabis policies and perceptions.

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Section: Cannabis Hiv and Gut-brain Axismentioning

confidence: 99%

Therapeutic Potential of Cannabis: A Comprehensive Review of Current and Future Applications

Leinen,

Mohan,

Premadasa

et al. 2023

Biomedicines

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RNA-binding proteins potentially regulate alternative splicing of immune/inflammatory-associated genes during the progression of generalized pustular psoriasis

Zhou,

Hu,

et al. 2024

Arch Dermatol Res

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Regulatory Roles of Long Non-Coding RNAs in Arterial Stiffness and Hypertension: Insights from Two African American Studies

Vargas,

Abbas,

Goodney

et al. 2024

Preprint

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BackgroundArterial stiffness, commonly assessed via pulse wave velocity (PWV), is marked by reduced arterial elasticity and serves as a significant risk factor for cardiovascular disease and an early indicator of hypertension. This study investigated the regulatory roles of long non-coding RNAs (lncRNAs) in modulating mRNAs associated with arterial stiffness and hypertension, with a particular focus on African Americans, a population disproportionately impacted by hypertension.MethodsWe utilized whole-blood transcriptome sequencing data from two African American (AA) cohorts with high hypertension prevalence: the GENE-FORECAST study (436 subjects) and the MH-GRID study (179 subjects). Our objectives were to: (1) identify lncRNAs and mRNAs differentially expressed (DE) between the upper and lower tertiles of PWV, (2) determine DE lncRNAs associated with the expression levels of each DE mRNA, and (3) link the lncRNA-modulated mRNAs to hypertension across both datasets.ResultsDifferential expression analysis revealed 1,035 DE mRNAs and 31 DE lncRNAs between upper and lower PWV groups. Then lncRNA-mRNA pairs significantly associated were identified, involving 31 unique lncRNAs and 1,034 unique mRNAs. Finally, 22 of the lncRNA-modulated mRNAs initially linked to PWV were found associated with hypertension, in both datasets. Interestingly, 30 lncRNAs were linked to the expression of UCP2 (Uncoupling Protein 2), a gene implicated in oxidative stress and endothelial function.ConclusionsOur findings underscore the significant roles of lncRNAs in regulating gene expression associated with arterial stiffness and hypertension. The differential expression of UCP2 in relation to PWV and hypertension, along with its potential regulation by lncRNAs, offers valuable insights into the molecular mechanisms underlying arterial stiffness and its connection with hypertension.

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Cannabinoid enhancement of lncRNA MMP25-AS1/MMP25 interaction reduces neutrophil infiltration and intestinal epithelial injury in HIV/SIV infection

Cited by 5 publications

References 62 publications

Therapeutic Potential of Cannabis: A Comprehensive Review of Current and Future Applications

Therapeutic Potential of Cannabis: A Comprehensive Review of Current and Future Applications

RNA-binding proteins potentially regulate alternative splicing of immune/inflammatory-associated genes during the progression of generalized pustular psoriasis

Regulatory Roles of Long Non-Coding RNAs in Arterial Stiffness and Hypertension: Insights from Two African American Studies

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