Cannabinoids enhance N-methyl--aspartate-induced excitation of locus coeruleus neurons by CB1 receptors in rat brain slices

Mendiguren, Arantxa Eceiza

doi:10.1016/s0304-3940(04)00288-5

Cited by 3 publications

(4 citation statements)

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“…(4) This hypothesis is consistent with a report that HCRT induces potentiation of NMDA receptor-mediated neurotransmission via a PLC/PKCdependent insertion of NMDA receptors in dopaminergic synapses of the ventral tegmental area (Borgland et al, 2006). Collectively, considering that LC somatodendritic secretion provides a negative feedback via autoreceptors to inhibit LC activity (Huang et al, 2007), HCRT modulation of NMDAR-mediated somatodendritic secretion may reflect a novel pathway for depressing LC hyperactivity-associated opioid withdrawal (Rasmussen, 1995;Mendiguren and Pineda, 2004). Note that although the HCRT-potentiated catecholamine release was measured at CFE sensor touching the soma, it remained possible that some of the evoked signals came from local terminals or dendrites.…”

Section: Discussionsupporting

confidence: 87%

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Hypocretin-1 Potentiates NMDA Receptor-Mediated Somatodendritic Secretion from Locus Ceruleus Neurons

Chen¹,

Mu²,

Huang³

et al. 2008

J. Neurosci.

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Section: Discussionsupporting

confidence: 87%

“…Glutamate, which activates NMDA receptor (NMDAR)-mediated neurotransmission, provide the major excitatory input to LC neurons and are involved in many physiological functions (Rasmussen, 1995;Mendiguren and Pineda, 2004). Interactions between hypocretins and glutamate/NMDA have been repeatedly reported.…”

Section: Introductionmentioning

confidence: 99%

Hypocretin-1 Potentiates NMDA Receptor-Mediated Somatodendritic Secretion from Locus Ceruleus Neurons

Chen¹,

Mu²,

Huang³

et al. 2008

J. Neurosci.

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“…Recently, evidence has emerged that systemic cannabinoid administration induces robust Fos expression in the rat LC (Patel & Hillard, 2003;Oropeza et al, 2005), where endogenous and exogenous cannabinoids modulate N-methyl-d-aspartate-induced excitation of NA neurons (Mendiguren & Pineda, 2004), whose spontaneous firing rate is increased by blockade of the endocannabinoid anandamide metabolism (Gobbi et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

Cannabinoids modulate spontaneous neuronal activity and evoked inhibition of locus coeruleus noradrenergic neurons

Muntoni

Pillolla

Melis

et al. 2006

Eur J of Neuroscience

107

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The noradrenergic pathway arising from the locus coeruleus (LC) is involved in the regulation of attention, arousal, cognitive processes and sleep. These physiological activities are affected by Cannabis exposure - both in humans and laboratory animals. In addition, exogenous cannabinoids, as well as pharmacological and genetic manipulation of the endocannabinoid system, are known to influence emotional states (e.g. anxiety) for which a contributory role of the LC-noradrenergic system has long been postulated. However, whether cannabinoid administration would affect the LC neuronal activity in vivo is still unknown. To this end, single-unit extracellular recordings were performed from LC noradrenergic cells in anaesthetized rats. Intravenous injection of both the synthetic cannabinoid agonist, WIN55212-2, and the main psychoactive principle of Cannabis, Delta9-tetrahydrocannabinol, dose-dependently increased the firing rate of LC noradrenergic neurons, with WIN55212-2 being the most efficacious. Similar results were obtained by the administration of these drugs into a lateral ventricle. Cannabinoid-induced stimulation of LC noradrenergic neuronal activity was counteracted by SR141716A, a cannabinoid receptor antagonist/reverse agonist, which by itself slightly reduced LC discharge rate. Moreover, WIN55212-2 suppressed the inhibition of noradrenergic cells produced by stimulation of the major gamma-aminobutyric acid (GABA)ergic afferent to the LC, the nucleus prepositus hypoglossi. Altogether, these findings suggest the involvement of noradrenergic pathways in some consequences of Cannabis intake (e.g. cognitive and attention deficits, anxiety reactions), as well as a role for cannabinoid receptors in basic brain activities sustaining arousal and emotional states.

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“…Single-unit extracellular recordings of LC cells were made as previously described (Mendiguren and Pineda, 2004;2007). The recording electrode consisted of an Omegadot glass micropipette pulled (Sutter Instruments, Novato, CA, USA) and filled with 50 mM NaCl, with the tip broken back to a size of 2-5 μm (3-5 MΩ).…”

Section: Electrophysiological Recordingsmentioning

confidence: 99%

Characterization of functional μ opioid receptor turnover in rat locus coeruleus: an electrophysiological and immunocytochemical study

Medrano

Santamarta

Pablos

et al. 2017

British J Pharmacology

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Cannabinoids enhance N-methyl--aspartate-induced excitation of locus coeruleus neurons by CB1 receptors in rat brain slices

Cited by 3 publications

References 0 publications

Hypocretin-1 Potentiates NMDA Receptor-Mediated Somatodendritic Secretion from Locus Ceruleus Neurons

Hypocretin-1 Potentiates NMDA Receptor-Mediated Somatodendritic Secretion from Locus Ceruleus Neurons

Cannabinoids modulate spontaneous neuronal activity and evoked inhibition of locus coeruleus noradrenergic neurons

Characterization of functional μ opioid receptor turnover in rat locus coeruleus: an electrophysiological and immunocytochemical study

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