Cannabinoids in Opioid Addiction Treatment: Pharmacological Mechanisms

Abstract

Opioid addiction, a chronic relapsing disorder, continues to impose great health and economic burden on our society. America's opioid crisis has become an epidemic due in part to the lack of effective treatments for the negative physical and emotional states suffered by the individuals during withdrawal from chronic opioid use. These symptoms might be major contributing factors to relapse. Recently, cannabis and cannabinoids have emerged as a potential therapeutic strategy in the treatment of opioid addiction. This review differs from many other reports in the field by focusing on the possible mechanisms underlying the effects of cannabinoids on the negative physical and emotional states induced by opioid withdrawal. We start by briefly outlining the current opioid crisis and how both opioids and cannabinoids affect the mammalian central nervous system (CNS). Next, we present findings that illustrate how cannabinoids may be used to enhance opioid analgesia and to mitigate opioid withdrawal syndromes. Finally, we summarize these findings and propose directions for future research.

Research on rolling bearing virtual-real fusion life prediction with digital twin

“…There are outlier points in the bootstrap samples generated randomly that are not conducive to the prediction accuracy, resulting in greater prediction deviation. In subsequent research, scholars used K-means method to cluster the data after expansion [15] to remove outlier points as much as possible and improve the quality of sample data. Literature [16] shows that the enlarged sample will bring additional errors to the life prediction results, which cannot be ignored.…”

Evaluation of the Analgesic Effect of High-Cannabidiol-Content Cannabis Extracts in Different Pain Models by Using Polymeric Micelles as Vehicles

“…Current pharmacological treatments do not effectively manage moderate and severe acute and chronic pain. In most cases, analgesics have insufficient activity, but the most effective analgesics produce serious adverse effects [2,3]. Some of the main medications prescribed for pain management are opioids, paracetamol, nonsteroidal anti-inflammatory drugs, muscle relaxants, anticonvulsants, antidepressants, and COX2 inhibitors [4].…”