Cannabis and Chromosomes

Martin, P A

doi:10.1016/s0140-6736(69)91326-9

Cited by 19 publications

(4 citation statements)

References 7 publications

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“…Moreover, chronic THC exposure may decrease the level of plasma folic acid, which plays an important role in preventing congenital malformation, in particular neural tube defects but also cardiac malformations, urinary tract anomalies, oro-facial clefts and limb reductions 35 . Animal studies on teratogen risk showed congenital anomalies (limb and extremity defects, encephalocele, eventration of abdominal visceral) in 57% of descendants of pregnant rats exposed to intraperitoneal emulsion of resin (4.2 mg/kg/day from day 1 to day 6 of gestation) 36 but they have not been confirmed later 37 , 38 .…”

Section: Discussionmentioning

confidence: 98%

Adverse events of recreational cannabis use during pregnancy reported to the French Addictovigilance Network between 2011 and 2020

Bouquet

Eiden²,

Fauconneau³

et al. 2022

Sci Rep

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Cannabis is the main illicit psychoactive substance used by pregnant women in France. The aim of the present national survey was to describe adverse events (AEs) of recreational cannabis use during pregnancy reported to the French Addictovigilance Network (FAN). Spontaneous reports (SRs) of AEs related to recreational cannabis use during pregnancy were collected by the FAN between 01/01/2011 and 31/01/2021 (excluding cannabidiol and synthetic cannabinoids). Over the study period, 160 SRs involved cannabis use alone or in association with tobacco (59% of all SRs) which increased. Among the 175 maternal AEs, the most commons were psychiatric AEs experienced by 96 (64.9%) women, in particular cannabis use disorders (n = 89, 60.1%), dependence (n = 54, 36.5%) and abuse (n = 21, 14.2%). Among the 57 fetal AEs, the most common were heart rhythm disorders that affected 25 (16.9%) fetuses and intrauterine growth restriction (IUGR) (n = 20, 13.5%). Among the 140 neonatal AEs, the most common were IUGR experienced by 39 (26.3%) newborns and prematurity (n = 32, 21.6%). Twelve cases of congenital malformations were observed and 4 intrauterine/neonatal deaths. Furthermore, some of these AEs (n = 13) were unexpected. Cannabis use during pregnancy has problematic consequences for both mothers and infants who need close monitoring.

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Section: Discussionmentioning

confidence: 98%

Adverse events of recreational cannabis use during pregnancy reported to the French Addictovigilance Network between 2011 and 2020

Bouquet

Eiden²,

Fauconneau³

et al. 2022

Sci Rep

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“…Cannabis resin is teratogenic in the rat {Persaud and Ellington, 1968). In vitro cytogenetic investigations with rat lymphocytes and rat embryonic fibroblasts showed no chromosome breaking activity of Cannabis resin (Martin, 1969). Rat embryonic cells in vitro exhibited no chromosome breaking activity after treatment of the mothers with Cannabis resin (Martin, 1969).…”

Section: Introductionmentioning

confidence: 93%

“…In vitro cytogenetic investigations with rat lymphocytes and rat embryonic fibroblasts showed no chromosome breaking activity of Cannabis resin (Martin, 1969). Rat embryonic cells in vitro exhibited no chromosome breaking activity after treatment of the mothers with Cannabis resin (Martin, 1969). With human lung explants in vitro Leuchtenberger et al (1973aLeuchtenberger et al ( , 1973b reported that smoke from marihuana cigarettes results in abnormalities in growth of the cells, mitosis, DNA synthesis, and in chromosomal aberrations.…”

Section: Introductionmentioning

confidence: 99%

Chromosomal Damage in Chronical Users of Cannabis In Vivo Investigation with Two-day Leukocyte Cultures

Herha¹,

Obe²

1974

Pharmacopsychiatry

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Chromosome analyses were performed with 48 h leukocyte cultures of 20 chronical Cannabis users and 20 controls. The frequencies of exchange type aberrations (chromatid interchanges, dicentric chromosomes) can be arranged as follows: controls < Cannabis users < Cannabis users with hepatitis history. The results are discussed with respect to a possible genetic risk of chronical cannabis usage. Zusammenfassung Es wurden Chromosomenuntersuchungen an 48 h Leukozytenkulturen von 20 chronischen Cannabis-Konsumenten durchgeführt und mit einer Kontrollgruppe von 20 Personen verglichen. Die Häufigkeit der Aberrationen vom Austauschtyp (Chromatidtranslokationen, dizentrische Chromosomen) war: Kontrollgruppe < Cannabis-Konsumenten < Cannabiskonsumenten mit vorangegangener Hepatitis. Die Ergebnisse werden im Hinblick auf ein mögliches genetisches Risiko bei chronischem Cannabis-Konsum diskutiert.

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“…As regards the risks of physical disease from the use of Cannabis, foetal studies in non-human species do indicate a wide range of embryotoxic effects (Persaud and Ellington, 1968;Martin, 1969) Apart from the possibly adverse action of Cannabis on epilepsy and diabetes raised by Hasleton, the question of accident proneness and increased road toll must surely be considered. The very carefully planned and controlled studies of Weil er al.…”

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confidence: 99%

Keep off the Grass?

Seal¹

1972

Aust N Z J Psychiatry

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Cannabis and Chromosomes

Cited by 19 publications

References 7 publications

Adverse events of recreational cannabis use during pregnancy reported to the French Addictovigilance Network between 2011 and 2020

Adverse events of recreational cannabis use during pregnancy reported to the French Addictovigilance Network between 2011 and 2020

Chromosomal Damage in Chronical Users of Cannabis In Vivo Investigation with Two-day Leukocyte Cultures

Keep off the Grass?

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