Cannabis craving in response to alcohol cues among adolescents and young adults in the laboratory and in daily life.

Wycoff, Andrea M.; Padovano, Hayley Treloar; Miranda, Robert

doi:10.1037/pha0000614

Cited by 9 publications

(18 citation statements)

References 45 publications

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“…The consistency of daily life results between this study and our previous sample (Wycoff et al, 2023) is notable for a few reasons.…”

Section: Discussionsupporting

confidence: 80%

“…We examined whether alcohol cues are associated with elevated predicted elevated cannabis craving among adolescents and emerging adults, though we did not find the parallel association in the laboratory (Wycoff et al, 2023). In this study, we sought to examine similar questions with a younger sample of adolescents who had not yet progressed to moderate or severe AUD and to examine alternative control conditions for alcohol cues in the laboratory.…”

Section: Discussionmentioning

confidence: 99%

“…Finally, we used additional mixed models in SAS PROC MIXED for our preregistered sensitivity tests. First, we retested hypotheses 1 and 2 using the water cue as the control condition instead of the baseline resting condition, to provide a closer test to that by Wycoff et al (2023). Second, we retested hypotheses 1 and 2 using the average of the two resting conditions as the control instead of the baseline resting condition only.…”

Section: Analytic Methodsmentioning

confidence: 99%

“…This study contributes to the cross-cue reactivity literature by testing whether nontreatment seeking younger adolescents (age 15-17 years) who use both alcohol and cannabis exhibit cannabis craving in response to alcohol cues in the laboratory and natural environment. We sought to extend Wycoff et al (2023) by examining younger adolescents and testing a different control condition in the laboratory to bypass any potential issues with using water as a control cue for alcohol. To do this, we used laboratory and EMA data from a recent etiological study on adolescent substance use that used community recruitment methods to enroll adolescents earlier in their substance-use trajectory.…”

mentioning

confidence: 99%

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Cannabis craving in response to alcohol cues in the laboratory and in daily life among adolescents ages 15–17 years

Wycoff,

Rogers,

Parlette

et al. 2023

Alcohol: Clinical and Experimental Research

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BackgroundMost adolescents who drink alcohol also use cannabis, and adolescents who use both substances experience worse long‐term outcomes than adolescents who only use one or the other. Recent work from clinical trials with adolescents and emerging adults found that alcohol cues are associated with elevated cannabis craving in the natural environment but not in the laboratory, highlighting cross‐cue reactivity as a potential intervention target. The present study extends this work to a younger sample of adolescents at an earlier stage of substance use to examine generalizability of prior findings and inform etiological mechanisms.MethodParticipants were 81 adolescents ages 15 to 17 who endorsed past‐month alcohol and lifetime cannabis use. They completed a laboratory cue reactivity protocol where they rated their cannabis craving during alcohol cue and control conditions. They also completed 24 days of ecological momentary assessment where they reported multiple times per day on their cannabis craving and whether alcohol cues were visible.ResultsMixed models demonstrated lower cannabis craving following alcohol cue presentation in the laboratory compared to control cues, but higher cannabis craving during moments when alcohol was visible in daily life compared to moments when alcohol was not visible. Frequency of cannabis use at baseline was associated with greater cannabis craving in the laboratory and in daily life regardless of cue type or alcohol visibility, and cannabis craving following alcohol cue presentation in the laboratory was positively related to daily‐life cannabis craving across contexts.ConclusionsThe present study adds to prior work suggesting that daily‐life cannabis craving is elevated when alcohol cues are visible. This cross‐cue reactivity may be one factor that drives and maintains alcohol and cannabis use in adolescence.

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“…The consistency of daily life results between this study and our previous sample (Wycoff et al, 2023) is notable for a few reasons.…”

Section: Discussionsupporting

confidence: 80%

Section: Discussionmentioning

confidence: 99%

Section: Analytic Methodsmentioning

confidence: 99%

mentioning

confidence: 99%

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Cannabis craving in response to alcohol cues in the laboratory and in daily life among adolescents ages 15–17 years

Wycoff,

Rogers,

Parlette

et al. 2023

Alcohol: Clinical and Experimental Research

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show abstract

“…One other study, to our knowledge, has bridged the human laboratory and natural environment with youth. Wycoff et al (2022) examined in vivo cue reactivity in the lab and natural environment and found alcohol‐induced cannabis craving in the laboratory predicted greater daily cannabis craving in the natural environment.…”

Section: Introductionmentioning

confidence: 99%

Peer‐elicited alcohol craving in adolescents and emerging adults: Bridging the laboratory and natural environment

Meisel

Padovano

Pielech

et al. 2023

Alcohol: Clinical and Experimental Research

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Background Although peers figure prominently in developmental models of alcohol use, our understanding of the influence of peer social context in cue reactivity paradigms with adolescents and emerging adults in the human laboratory and the natural environment is limited. This study tested associations between alcohol craving among youth in the human laboratory using alcohol‐related images, with and without peers, and in the natural environment using ecological momentary assessment (EMA). Methods Data for this preregistered secondary analysis were collected prior to randomization in two medication trials (N = 115). Participants completed an image cue exposure paradigm at the baseline laboratory session followed by approximately 7 days of EMA. Results In the laboratory, model‐based mean comparisons from multilevel models (MLMs) showed that all drinking images elicited greater craving than neutral images. No differences were observed across the three image categories containing alcohol. Image category by age interactions demonstrated that, compared to older youth, younger youth displayed lower craving in response to neutral versus social drinking context with peers images and older, compared to younger, youth displayed higher craving in response to nonsocial drinking images versus social drinking contexts with peers images. In the natural environment, craving was greatest when youth were in the presence of alcohol‐using peers and alcohol‐related cues, regardless of age. Laboratory craving to alcohol images was positively associated with craving in the natural environment. Conclusions For youth, peers are a salient social context associated with increased craving, particularly in the natural environment. Laboratory cue reactivity to alcohol images predicted real‐world craving, further supporting the ecological validity of this paradigm in youth.

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Cannabis craving in response to alcohol cues among adolescents and young adults in the laboratory and in daily life.

Wycoff¹,

Padovano²,

Miranda³

2023

Experimental and Clinical Psychopharmacology

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Cannabis use among adolescents and young adults who drink alcohol is prevalent and relates to poorer clinical outcomes. Interrelated factors, such as cross-reactivity to alcohol cues, may contribute to the high prevalence of cannabis use among young persons who drink alcohol. We tested whether systematic presentation of alcohol cues in the laboratory and naturalistic presence of alcohol cues in daily life elicit cannabis craving. Data were compiled from two clinical trials. Participants (N = 54) were adolescents and young adults ages 15–24 who reported consuming alcohol at least twice per week, expressed interest in reducing alcohol use, and reported lifetime cannabis use. Participants provided laboratory and daily-life smartphone report data prior to randomization to treatment conditions in the parent trials. Mixed-effect models tested a priori hypotheses, which received mixed support. Cannabis craving was not heightened following alcohol-cue presentation in the laboratory but was elevated in daily life when alcohol cues were visible. The effect of laboratory alcohol cues was moderated by cannabis use frequency, with higher frequencies associated with greater cannabis craving, while the effect of daily-life alcohol cues on cannabis craving was not moderated by cannabis use frequency. Finally, alcohol cue-induced cannabis craving in the laboratory was associated with greater daily-life cannabis craving, irrespective of the presence of naturalistic alcohol cues. Overall, exposure to alcohol cues in daily life may flag situations with increased risk of cannabis craving, supporting the idea of cross cue reactivity and implicating naturalistic alcohol cues as an intervention target for individuals who co-use alcohol and cannabis.

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Cannabis craving in response to alcohol cues among adolescents and young adults in the laboratory and in daily life.

Cited by 9 publications

References 45 publications

Cannabis craving in response to alcohol cues in the laboratory and in daily life among adolescents ages 15–17 years

Cannabis craving in response to alcohol cues in the laboratory and in daily life among adolescents ages 15–17 years

Peer‐elicited alcohol craving in adolescents and emerging adults: Bridging the laboratory and natural environment

Cannabis craving in response to alcohol cues among adolescents and young adults in the laboratory and in daily life.

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