Cannabis Use and Mania Symptoms: a Systematic Review and Meta-analysis

Gibbs, Melanie; Winsper, Catherine; Marwaha, Steven; Gilbert, Eleanor; Broome, Matthew R.; Singh, Sudhir Kumar

doi:10.1016/s0924-9338(15)30892-0

Cited by 5 publications

(5 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The observed heightened risk of unintentional overdoses could be associated with the misuse of substances other than cannabis (eg, opioids, cocaine, or amphetamines). Cannabis use may be associated with greater impulsivity, increased risk-taking behaviors, and impaired judgment, and may increase vulnerability to development of manic symptoms, 39 as well as decreased likelihood of help seeking. The increased risk of self-harm in those with CUD might be associated with negative associations of cannabis with mood and increased severity of depression and/or anxiety, [40][41][42][43] an impulsive response to a stressful event, 44 and/or emergence of psychotic symptoms.…”

Section: Discussionmentioning

confidence: 99%

Association of Cannabis Use With Self-harm and Mortality Risk Among Youths With Mood Disorders

et al. 2021

View full text Add to dashboard Cite

IMPORTANCE Cannabis use and cannabis use disorder (CUD) are common among youths and young adults with mood disorders, but the association of CUD with self-harm, suicide, and overall mortality risk is poorly understood in this already vulnerable population.OBJECTIVE To examine associations of CUD with self-harm, suicide, and overall mortality risk in youths with mood disorders. DESIGN, SETTING, AND PARTICIPANTSA population-based retrospective cohort study was performed using Ohio Medicaid claims data linked with death certificate data. The analysis included 204 780 youths (aged 10-24 years) with a diagnosis of mood disorders between July 1, 2010, and December 31, 2017, who were followed up to 365 days from the index diagnostic claim until the end of enrollment, the self-harm event, or death. Statistical analysis was performed from April 4 to July 17, 2020. EXPOSURE Physician-diagnosed CUD defined using outpatient and inpatient claims from 180 days prior to the index mood disorder diagnostic claim through the 365-day follow-up period.MAIN OUTCOMES AND MEASURES Nonfatal self-harm, all-cause mortality, and deaths by suicide, unintentional overdose, motor vehicle crashes, and homicide. Marginal structural models using inverse probability weights examined associations between CUD and outcomes. RESULTSThis study included 204 780 youths (133 081 female participants [65.0%]; mean [SD] age at the time of mood disorder diagnosis, 17.2 [4.10] years). Cannabis use disorder was documented for 10.3% of youths with mood disorders (n = 21 040) and was significantly associated with older age (14-18 years vs 10-13 years: adjusted risk ratio [

show abstract

Section: Discussionmentioning

confidence: 99%

Association of Cannabis Use With Self-harm and Mortality Risk Among Youths With Mood Disorders

et al. 2021

View full text Add to dashboard Cite

show abstract

“…3,4 Use of cannabis may, however, lead to addiction (ie, cannabis use disorder [CUD]). 5 Cannabis use disorder is frequent among individuals with affective disorders 6 and, in this group, is associated with increased symptom severity, 7,8 suicidality, 9 and mortality. 10 Although disputed, evidence suggests that use of cannabis may be associated with increased risk of developing psychiatric disorders 11 ; however, the association could also be reversed (ie, premorbid illness leading to cannabis use) or attributable to confounding (ie, common genetic liability for cannabis use and psychiatric disorders 12 ).…”

mentioning

confidence: 99%

Cannabis Use Disorder and Subsequent Risk of Psychotic and Nonpsychotic Unipolar Depression and Bipolar Disorder

et al. 2023

View full text Add to dashboard Cite

ImportanceCannabis use is increasing worldwide and is suspected to be associated with increased risk of psychiatric disorders; however, the association with affective disorders has been insufficiently studied.ObjectiveTo examine whether cannabis use disorder (CUD) is associated with an increased risk of psychotic and nonpsychotic unipolar depression and bipolar disorder and to compare associations of CUD with psychotic and nonpsychotic subtypes of these diagnoses.Design, Setting, and ParticipantsThis prospective, population-based cohort study using Danish nationwide registers included all individuals born in Denmark before December 31, 2005, who were alive, aged at least 16 years, and living in Denmark between January 1, 1995, and December 31, 2021.ExposureRegister-based diagnosis of CUD.Main Outcome and MeasuresThe main outcome was register-based diagnosis of psychotic or nonpsychotic unipolar depression or bipolar disorder. Associations between CUD and subsequent affective disorders were estimated as hazard ratios (HRs) using Cox proportional hazards regression with time-varying information on CUD, adjusting for sex; alcohol use disorder; substance use disorder; having been born in Denmark; calendar year; parental educational level (highest attained); parental cannabis, alcohol, or substance use disorders; and parental affective disorders.ResultsA total of 6 651 765 individuals (50.3% female) were followed up for 119 526 786 person-years. Cannabis use disorder was associated with an increased risk of unipolar depression (HR, 1.84; 95% CI, 1.78-1.90), psychotic unipolar depression (HR, 1.97; 95% CI, 1.73-2.25), and nonpsychotic unipolar depression (HR, 1.83; 95% CI, 1.77-1.89). Cannabis use was associated with an increased risk of bipolar disorder in men (HR, 2.96; 95% CI, 2.73-3.21) and women (HR, 2.54; 95% CI, 2.31-2.80), psychotic bipolar disorder (HR, 4.05; 95% CI, 3.52-4.65), and nonpsychotic bipolar disorder in men (HR, 2.96; 95% CI, 2.73-3.21) and women (HR, 2.60; 95% CI, 2.36-2.85). Cannabis use disorder was associated with higher risk for psychotic than nonpsychotic subtypes of bipolar disorder (relative HR, 1.48; 95% CI, 1.21-1.81) but not unipolar depression (relative HR, 1.08; 95% CI, 0.92-1.27).Conclusions and RelevanceThis population-based cohort study found that CUD was associated with an increased risk of psychotic and nonpsychotic bipolar disorder and unipolar depression. These findings may inform policies regarding the legal status and control of cannabis use.

show abstract

“…El consumo además puede influir en las manifestaciones clínicas del trastorno e, incluso se sugiere un papel etiológico o, al menos, precipitante del trastorno dado que adelanta la edad de inicio del TB. El consumo de cannabis se ha asociado con la inducción de hipomanía (Marwaha et al 2018) y manía (Gibbs et al 2014, Tijssen et al 2010, Henquet et al 2006.…”

Section: Discussionunclassified

“…Otros trabajos centrados en muestras clínicas de pacientes bipolares asocian el consumo de cannabis más con los episodios maníacos que depresivos o con la presencia de ciclos rápidos o características atípicas del cuadro. En una revisión se concluye que el consumo de cannabis se asocia con la exacerbación de la manía e incrementaba 3 veces el riesgo de la aparición de primeros episodios maníacos (Gibbs et al 2014). En otra revisión, el consumo de cannabis se asocia con una edad más cannabis en bipolares se asocia con más tentativas suicidas (Agrawal et al 2011) pero, en el estudio NESARC, el consumo de cannabis en bipolares no presentaba diferencias respecto al riesgo de suicidio (Lev-Ran et al 2013a).…”

Section: Repercusión Del Consumo De Cannabis En La Evolución Del Trasunclassified

Repercusiones del consumo de cannabis en la evolución del trastorno bipolar

Arias

Alberich

Zorrilla

et al. 2020

Psiquiatría Biológica

View full text Add to dashboard Cite

En los pacientes con trastorno bipolar existe una elevada prevalencia de consumo de drogas, siendo el cannabis una de las principales. El consumo de cannabis puede modificar las manifestaciones clínicas y el curso evolutivo del trastorno. El objetivo del presente trabajo es estudiar la influencia del consumo de cannabis sobre la evolución del trastorno bipolar a partir de estudios de seguimiento de pacientes bipolares. Se ha realizado una revisión sistemática realizando una búsqueda de artículos en Medline. Se han obtenido 5 artículos sobre cohortes de sujetos bipolares que estudian el efecto de dicho consumo. El consumo de cannabis se presenta como un factor pronóstico negativo, con menor recuperación clínica, peor funcionamiento global, más tiempo en episodios afectivos y, posiblemente, mayor frecuencia de ciclos rápidos y episodios maníacos o mixtos. El cese del consumo durante el seguimiento mejora la evolución. El consumo de alcohol y otras drogas son muy frecuentes entre los consumidores de cannabis y se asocian a una evolución negativa. Palabras clave: trastorno bipolar, consumo de cannabis, evolución.

show abstract

Cannabis Use and Mania Symptoms: a Systematic Review and Meta-analysis

Cited by 5 publications

References 18 publications

Association of Cannabis Use With Self-harm and Mortality Risk Among Youths With Mood Disorders

Association of Cannabis Use With Self-harm and Mortality Risk Among Youths With Mood Disorders

Cannabis Use Disorder and Subsequent Risk of Psychotic and Nonpsychotic Unipolar Depression and Bipolar Disorder

Repercusiones del consumo de cannabis en la evolución del trastorno bipolar

Contact Info

Product

Resources

About