Cannabis use moderates the relationship between pain and negative affect in adults with opioid use disorder

Wilson, Marian; Gogulski, Hannah Y.; Cuttler, Carrie; Bigand, Teresa; Oluwoye, Oladunni; Barbosa‐Leiker, Celestina; Roberts, Mary L.

doi:10.1016/j.addbeh.2017.10.012

Cited by 28 publications

(24 citation statements)

References 42 publications

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“…Cannabinoids, given their antidepressant and anxiolytic properties, may interact with opioid addiction and withdrawal circuitry by affecting negative emotional states. Various authors have reported that activation of CB1Rs elicits anxiolytic and antidepressant effects in animal models [39,106,107]. In contrast, Wilson and Roberts [105] suggested that cannabis use strengthens the relationship between pain and negative affective states through self-efficacy (the confidence that a patient can manage their symptoms using MAT).…”

Section: Cannabinoids and Opioid-induced Negative Emotional Statesmentioning

confidence: 99%

“…A clinical study by Fabre and McLendon [110] found that anxiety levels drastically improved after 11 daily doses of nabilone, a synthetic cannabinoid with effects that mimic Δ 9 -THC and endogenous cannabinoids [111]; these effects also persisted for 17 days after discontinuation of nabilone. Likewise, inhibition of CB1Rs resulted in increased anxiety when rats were subjected to light/dark choice tests or elevated plus mazes (EPM) [106]. These effects, caused by CB1 and non-CB1 receptors such as the serotonin 5-HT1A receptor, [112] were also produced by blocking the degradation of anandamide using fatty acid amide hydrolase (FAAH) [106].…”

Section: Cannabis Mitigates Anxietymentioning

confidence: 99%

“…Likewise, inhibition of CB1Rs resulted in increased anxiety when rats were subjected to light/dark choice tests or elevated plus mazes (EPM) [106]. These effects, caused by CB1 and non-CB1 receptors such as the serotonin 5-HT1A receptor, [112] were also produced by blocking the degradation of anandamide using fatty acid amide hydrolase (FAAH) [106]. Crippa et al [111] reported that patients with social anxiety disorder were significantly less anxious after 400 mg of CBD compared to placebo control subjects.…”

Section: Cannabis Mitigates Anxietymentioning

confidence: 99%

“…Rodriguez Bambico et al [135] found that low doses of WIN55, -212-2 possessed antidepressant-like qualities that were blocked by both rimonabant and parachlorophenylalanine (a 5-HTdepleting agent) in forced swimming test. This increase in monoaminergic transmission may play a role in promoting neurogenesis in the hippocampus, a characteristic feature of many antidepressants [106,136]. These results aside, it has also been shown that higher doses of cannabinoids decrease 5-HT signaling in the brain and are associated with anxiogenic and depressant-like behaviors [133,137].…”

Section: Mechanisms Of Cannabinoids Rescue Opioid-induced Negative Emmentioning

confidence: 99%

“…Also, these effects may also be the result of transient receptor potential vanilloid one receptors (TRPV1) activation, which produces anxiogenic effects at high doses of CBD [133]. TRPV1 receptors are a natural target of the anandamide, and therefore a possible target for non-endogenous cannabinoids as well [106]. Other reports attribute the biphasic effects to CB1Rs on glutamatergic and GABAergic neurons, since genetic deletion of each of these receptors in C57BL/6N mice resulted in abrogation of anxiolytic and anxiogenic effects respectively [140][141][142][143].…”

Section: Mechanisms Of Cannabinoids Rescue Opioid-induced Negative Emmentioning

confidence: 99%

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Cannabinoids in Opioid Addiction Treatment: Pharmacological Mechanisms

Zuo¹,

Tam²,

Bekker³

et al. 2019

J Alcohol Drug Depend

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Opioid addiction, a chronic relapsing disorder, continues to impose great health and economic burden on our society. America's opioid crisis has become an epidemic due in part to the lack of effective treatments for the negative physical and emotional states suffered by the individuals during withdrawal from chronic opioid use. These symptoms might be major contributing factors to relapse. Recently, cannabis and cannabinoids have emerged as a potential therapeutic strategy in the treatment of opioid addiction. This review differs from many other reports in the field by focusing on the possible mechanisms underlying the effects of cannabinoids on the negative physical and emotional states induced by opioid withdrawal. We start by briefly outlining the current opioid crisis and how both opioids and cannabinoids affect the mammalian central nervous system (CNS). Next, we present findings that illustrate how cannabinoids may be used to enhance opioid analgesia and to mitigate opioid withdrawal syndromes. Finally, we summarize these findings and propose directions for future research.

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Section: Cannabinoids and Opioid-induced Negative Emotional Statesmentioning

confidence: 99%

Section: Cannabis Mitigates Anxietymentioning

confidence: 99%

Section: Cannabis Mitigates Anxietymentioning

confidence: 99%

Section: Mechanisms Of Cannabinoids Rescue Opioid-induced Negative Emmentioning

confidence: 99%

Section: Mechanisms Of Cannabinoids Rescue Opioid-induced Negative Emmentioning

confidence: 99%

See 3 more Smart Citations

Cannabinoids in Opioid Addiction Treatment: Pharmacological Mechanisms

Zuo¹,

Tam²,

Bekker³

et al. 2019

J Alcohol Drug Depend

View full text Add to dashboard Cite

show abstract

A Scoping Review of the Use of Cannabis and Its Extracts as Potential Harm Reduction Strategies: Insights from Preclinical and Clinical Research

Siklos-Whillans

Bacchus

Manwell

2020

Int J Ment Health Addiction

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Emerging Clinical Technology: Application of Machine Learning to Chronic Pain Assessments Based on Emotional Body Maps

et al. 2020

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Depression and anxiety co-occur with chronic pain, and all three are thought to be caused by dysregulation of shared brain systems related to emotional processing associated with body sensations. Understanding the connection between emotional states, pain, and bodily sensations may help understand chronic pain conditions. We developed a mobile platform for measuring pain, emotions, and associated bodily feelings in chronic pain patients in their daily life conditions. Sixty-five chronic back pain patients reported the intensity of their pain, 11 emotional states, and the corresponding body locations. These variables were used to predict pain 2 weeks later. Applying machine learning, we developed two predictive models of future pain, emphasizing interpretability. One model excluded pain-related features as predictors of future pain, and the other included pain-related predictors. The best predictors of future pain were interactive effects of (a) body maps of fatigue with negative affect and (b) positive affect with past pain. Our findings emphasize the contribution of emotions, especially emotional experience felt in the body, to understanding chronic pain above and beyond the mere tracking of pain levels. The results may contribute to the generation of a novel artificial intelligence framework to help in the development of better diagnostic and therapeutic approaches to chronic pain.

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Cannabis use moderates the relationship between pain and negative affect in adults with opioid use disorder

Cited by 28 publications

References 42 publications

Cannabinoids in Opioid Addiction Treatment: Pharmacological Mechanisms

Cannabinoids in Opioid Addiction Treatment: Pharmacological Mechanisms

A Scoping Review of the Use of Cannabis and Its Extracts as Potential Harm Reduction Strategies: Insights from Preclinical and Clinical Research

Emerging Clinical Technology: Application of Machine Learning to Chronic Pain Assessments Based on Emotional Body Maps

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