Cannflavins – From plant to patient: A scoping review

Erridge, Simon; Mangal, Nagina; Salazar, Oliver; Pacchetti, Barbara

doi:10.1016/j.fitote.2020.104712

Cited by 31 publications

(31 citation statements)

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“…Luteolin also showed a protective effect against lipopolysaccharides (LPS)-induced ALI mice model by inhibition of MAPK pathways, leading to inhibition of the NF-κB pathway and IKB degradation (Kuo et al 2011 ). Caflanone possesses anti-inflammatory activity by inhibition of microsomal prostaglandin E synthase 1 and 5-lipoxygenase (Erridge et al 2020 ).…”

Section: Immunomodulatory and Anti-inflammatory Activities Of Flavonoidsmentioning

confidence: 99%

“…Inhibition of PKC-d significantly reduces the TNF-a-induced IL-8 levels. Interestingly, fisetin has a similar effect to the broad protein kinase inhibitor, Staurosporine, hence it can be (Kim et al 2018;Kuo et al 2011;Liu et al 2018) Caflanone Inhibits microsomal prostaglandin E synthase 1 and 5-lipoxyganse (Erridge et al 2020) employed as a potential immunomodulator in lung inflammation (Lee et al 2018).…”

Section: Flavonols: Quercetin and Fisetinmentioning

confidence: 99%

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Flavonoids are promising safe therapy against COVID-19

et al. 2021

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Flavonoids are a class of phenolic natural products, well-identified in traditional and modern medicines in the treatment of several diseases including viral infection. Flavonoids showed potential inhibitory activity against coronaviruses including the current pandemic outbreak caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and designated as COVID-19. Here, we have collected all data related to the potential inhibitory mechanisms of flavonoids against SARS-CoV-2 infection and their significant immunomodulatory activities. The data were mapped and compared to elect major flavonoids with a promising role in the current pandemic. Further, we have linked the global existence of flavonoids in medicinal plants and their role in protection against COVID-19. Computational analysis predicted that flavonoids can exhibit potential inhibitory activity against SARS-CoV-2 by binding to essential viral targets required in virus entry and/ or replication. Flavonoids also showed excellent immunomodulatory and anti-inflammatory activities including the inhibition of various inflammatory cytokines. Further, flavonoids showed significant ability to reduce the exacerbation of COVID-19 in the case of obesity via promoting lipids metabolism. Moreover, flavonoids exhibit a high safety profile, suitable bioavailability, and no significant adverse effects. For instance, plants rich in flavonoids are globally distributed and can offer great protection from COVID-19. The data described in this study strongly highlighted that flavonoids particularly quercetin and luteolin can exhibit promising multi-target activity against SARS-CoV-2, which promote their use in the current and expected future outbreaks. Therefore, a regimen of flavonoid-rich plants can be recommended to supplement a sufficient amount of flavonoids for the protection and treatment from SARS-CoV-2 infection.

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Section: Immunomodulatory and Anti-inflammatory Activities Of Flavonoidsmentioning

confidence: 99%

Section: Flavonols: Quercetin and Fisetinmentioning

confidence: 99%

Flavonoids are promising safe therapy against COVID-19

et al. 2021

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“…Cannflavin A's anti-inflammatory activity is 30 times stronger than Aspirin [155]. This anti-inflammatory effect is explained by the inhibition of the molecular targets microsomal prostaglandin E synthase-1 (mPGES-1) and 5-lipoxygenase (5-LO) [156].…”

Section: Flavonoidsmentioning

confidence: 99%

Topical Use of Cannabis sativa L. Biochemicals

Mnekin

Ripoll

2021

Cosmetics

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Cannabis sativa L. plant is currently attracting increasing interest in cosmetics and dermatology. In this review, the biologically active compounds of hemp are discussed. Particularly the complex interactions of cannabinoids with the endocannabinoid system of the skin to treat various conditions (such as acne, allergic contact dermatitis, melanoma, and psoriasis) with clinical data. Moreover, the properties of some cannabinoids make them candidates as cosmetic actives for certain skin types. Hemp seed oil and its minor bioactive compounds such as terpenes, flavonoids, carotenoids, and phytosterols are also discussed for their added value in cosmetic formulation.

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“… α-terpineol Antimicrobial; Anti-inflammatory; Analgesic; Nociception inhibition; Antimicrobial [ 35 , 92 , 122 , 125 , 141 , 142 ] Major Flavonoids 1. Cannflavin A Analgesic Anti-inflammatory [ 33 , 143 , 144 , 145 , 146 ] 2. Cannflavin B Analgesic Anti-inflammatory [ 33 , 143 , 144 , 145 , 146 ] …”

Section: Current Uses Of Cannabinoids In Modern Dentistrymentioning

confidence: 99%

“… Cannflavin A Analgesic Anti-inflammatory [ 33 , 143 , 144 , 145 , 146 ] 2. Cannflavin B Analgesic Anti-inflammatory [ 33 , 143 , 144 , 145 , 146 ] …”

Section: Current Uses Of Cannabinoids In Modern Dentistrymentioning

confidence: 99%

The Current and Potential Application of Medicinal Cannabis Products in Dentistry

Lowe

Toyang²,

Steele

et al. 2021

Dentistry Journal

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Oral and dental diseases are a major global burden, the most common non-communicable diseases (NCDs), and may even affect an individual’s general quality of life and health. The most prevalent dental and oral health conditions are tooth decay (otherwise referred to as dental caries/cavities), oral cancers, gingivitis, periodontitis, periodontal (gum) disease, Noma, oro-dental trauma, oral manifestations of HIV, sensitive teeth, cracked teeth, broken teeth, and congenital anomalies such as cleft lip and palate. Herbs have been utilized for hundreds of years in traditional Chinese, African and Indian medicine and even in some Western countries, for the treatment of oral and dental conditions including but not limited to dental caries, gingivitis and toothaches, dental pulpitis, halitosis (bad breath), mucositis, sore throat, oral wound infections, and periodontal abscesses. Herbs have also been used as plaque removers (chew sticks), antimicrobials, analgesics, anti-inflammatory agents, and antiseptics. Cannabis sativa L. in particular has been utilized in traditional Asian medicine for tooth-pain management, prevention of dental caries and reduction in gum inflammation. The distribution of cannabinoid (CB) receptors in the mouth suggest that the endocannabinoid system may be a target for the treatment of oral and dental diseases. Most recently, interest has been geared toward the use of Cannabidiol (CBD), one of several secondary metabolites produced by C. sativa L. CBD is a known anti-inflammatory, analgesic, anxiolytic, anti-microbial and anti-cancer agent, and as a result, may have therapeutic potential against conditions such burning mouth syndrome, dental anxiety, gingivitis, and possible oral cancer. Other major secondary metabolites of C. sativa L. such as terpenes and flavonoids also share anti-inflammatory, analgesic, anxiolytic and anti-microbial properties and may also have dental and oral applications. This review will investigate the potential of secondary metabolites of C. sativa L. in the treatment of dental and oral diseases.

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Cannflavins – From plant to patient: A scoping review

Cited by 31 publications

References 50 publications

Flavonoids are promising safe therapy against COVID-19

Flavonoids are promising safe therapy against COVID-19

Topical Use of Cannabis sativa L. Biochemicals

The Current and Potential Application of Medicinal Cannabis Products in Dentistry

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