Canola Oil Influence on Azoxymethane-induced Colon Carcinogenesis, Hypertriglyceridemia and Hyperglycemia in Kunming Mice

Abstract

Azoxymethane (AOM) is a potent genotoxic carcinogen which specifically induces colon cancer. Hyperlipidemia and diabetes have several influences on colon cancer development, with genetic and environmental exposure aspects. Here, we investigated plasma lipid and glucose concentrations in Kunming mice randomized into four groups; control (no AOM or oil exposure), AOM control, AOM + pork oil, and AOM + canola oil. Aberrant crypt foci (ACF), plasma cholesterol, plasma triglyceride, plasma glucose and organ weight were examined 32 weeks after AOM injection. Results revealed that AOM exposure significantly increased ACF number, plasma triglyceride and glucose level. Further, male mice displayed a much higher plasma triglyceride level than female mice in the AOM control group. Dietary fat significantly inhibited AOM-induced hypertriglyceridemia, and canola oil had stronger inhibitory effect than pork oil. AOM-induced hyperglycemia had no sex-difference and was not significantly modified by dietary fat. However, AOM itself not change plasma cholesterol level. AOM significantly increased liver and spleen weight in male mice, but decreased kidney weight in female mice. On the other hand, mice testis weight decreased when fed canola oil. AOM could induce colorectal carcinogenesis, hypertriglyceridemia and hyperglycemia in Kunming mice at the same time, with subsequent studies required to investigate their genome association.

Luteolin, a Bioflavonoid Inhibits Colorectal Cancer through Modulation of Multiple Signaling Pathways: A Review

“…Many signaling pathways are deregulated during the progression of colon cancer (Pandurangan, 2013;Pandurangan and Esa, 2013;Pandurangan and Esa, 2014;). Epidemiological and experimental studies suggest that colon cancer is strongly influenced by nutritional factors, including the amount and composition of dietary fat (Willet et al, 1990;Pandurangan et al, 2013c;He et al, 2014).…”

Effects of Two Traditional Chinese Cooking Oils, Canola and Pork, on pH and Cholic Acid Content of Faeces and Colon Tumorigenesis in Kunming Mice

“…He et al, 2014 observed that in Kunming mice exposed to AOM plus canola oil had a strong inhibitory effect of AOM-induced colorectal carcinogenesis. On the other hand, in an 8-year epidemiological study, olive oil (contained in fried foods) was found to protect against the development of colon cancer (Galeone et al, 2007).…”

Preventive effects of Resveratrol against azoxymethane-induced testis injury in rats

“…Azoxymethane (AOM) is a potent carcinogen for colon and liver (He, Cichello, Duan, & Zhou, ; Nakanishi, Kataoka, Kuwahara, & Ohnishi, ). Hepatotoxic effects were also shown in animal models (Khurana, Shah, & Twaddell, ).…”

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