Luteolin, a Bioflavonoid Inhibits Colorectal Cancer through Modulation of Multiple Signaling Pathways: A Review

Evaluation of the Wound Healing Properties of Luteolin Ointments on Excision and Incision Wound Models in Diabetic and Non-Diabetic Rats

“…Presence of hydroxyl moieties and 2-3 carbon double bond are responsible for its several biochemical and pharmacological activities [18,19] like anti-inflammatory, antioxidant [6,[18][19][20][21][22], anticancer [18,22], antimicrobial [19,22], anti-allergic [22], anti-diabetic [19]. These evidence indicated that many biological activities of Luteolin (e.g.…”

“…Flavonoids known as bioactive compounds with polyphenolic structure are widely distributed in plant kingdom [19]. Literature data indicated that more than 8000 individual flavonoids [18] have been identified and classified into various sub-groups including flavonols, flavones, flavanols, flavanones, isoflavones [18,19].…”

“…Literature data indicated that more than 8000 individual flavonoids [18] have been identified and classified into various sub-groups including flavonols, flavones, flavanols, flavanones, isoflavones [18,19]. Moreover, antioxidant [18,20], anti-inflammatory, anticancer [18,20,21], neuro-protective and cardioprotective effects [18] of these components have been reported in many studies.…”

“…Luteolin (3',4',5,7-tetrahydroxyflavone), which is naturally distributed among several plant species such as medicinal plants, vegetables and fruits [18,21,22], is structurally classified under the group of flavones [18][19][20]. Presence of hydroxyl moieties and 2-3 carbon double bond are responsible for its several biochemical and pharmacological activities [18,19] like anti-inflammatory, antioxidant [6,[18][19][20][21][22], anticancer [18,22], antimicrobial [19,22], anti-allergic [22], anti-diabetic [19].…”

Dietary Ziziphus jujuba Fruit Influence on Aberrant Crypt Formation and Blood Cells in Colitis-Associated Colorectal Cancer Mice

“…The consumption of diet-containing carcinogens is associated with increasing risk of colon cancer and it was also documented that high consumption of plant-based foods might decrease the cancer risk (Abdull Razis and Noor, 2013). Epidemiological studies have indicated that CRC is strongly related with diet, and thus it may be possible to prevent the incidence of this cancer through dietary modification (Pandurangan and Esa, 2014).…”