Canonical DNA minor groove insertion of bisbenzamidine–Ru(ii) complexes with chiral selectivity

Abstract

We report the first Ru(ii) coordination compounds that interact with DNA through a canonical minor groove insertion mode and with selectivity for A/T rich sites.

The 55th Bürgenstock Conference under the Banner of Sustainability**

“…Mascareñas and coworkers developed several strategies that enable cell penetration and internalization of a metal complex. [46] For instance, they designed a peptide that upon binding to the palladium center increases its capacity for cellular uptake, which is followed by binding to a natural basic region from the GCN4 bZIP transcription factor, thereby precisely localizing the complex in the cell. [47] Mascareñas then took advantage of such an efficient internalization of the metal-…”

The 55th Bürgenstock Conference under the Banner of Sustainability**

“…Mascareñas and coworkers developed several strategies that enable cell penetration and internalization of a metal complex. [46] For instance, they designed a peptide that upon binding to the palladium center increases its capacity for cellular uptake, which is followed by binding to a natural basic region from the GCN4 bZIP transcription factor, thereby precisely localizing the complex in the cell. [47] Mascareñas then took advantage of such an efficient internalization of the metal-Angewandte Chemie Tagungsbericht loprotein, using it as a catalyst for depropargylation reactions inside living mammalian cells, setting the stage for artificial metabolism-like reactions working in the native living environment of enzymes.…”

Autocatalytic photodegradation of [Ru(ii)(2,2′-bipyridine)2DAD]+(DADH = 1,2-dihydroxyanthracene-9,10-dione) by hydrogen peroxide under acidic aqueous conditions

“…Although pure enantiomers are undoubtedly not critical for photodecomposition studies in achiral environments, they are potentially more interesting when bound in chiral environments; the obvious example being that of DNA and minor/major groove binding. 10 Hence, for completeness the two pure enantiomers were produced using the simple method developed by von Zelewski and co-workers. 11 The reflux of DADH in aqueous ethylene glycol with one equivalent of either ∆−PRu or Λ−PRu and triethylamine resulted in the formation of a purple solution.…”