Autocatalytic photodegradation of [Ru(ii)(2,2′-bipyridine)₂DAD]⁺(DADH = 1,2-dihydroxyanthracene-9,10-dione) by hydrogen peroxide under acidic aqueous conditions

Abstract

As part of a continuing effort to identify ruthenium agents capable of the photorelease of anthraquinone-based ligands the complexes Δ/Λ-[Ru(bpy)2DAD]+ (bpy = 2,2’-bipyridine) were produced by the reaction of 1,2-dihydoxyanthracene-9,10-dione...

Recent advances in photorelease complexes for therapeutic applications

“…Perspective lifetimes of only 5-7 ps, were shown to release the anthraquinone ligand in the presence of hydrogen peroxide. 86,87 The decomposition of RU29 would appear to be promoted by an autocatalytic process, which helps explain why it can readily eject the anthraquinone. To date no biological experiments were carried out to ascertain if such complexes would have a therapeutic application.…”