2021
DOI: 10.1182/bloodadvances.2021004845
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Canonical Wnt: a safeguard and threat for erythropoiesis

Abstract: Myeloid dysplastic syndrome (MDS) reflects a preleukemic BM disorder with limited treatment options and poor disease survival1. As only a minority of MDS patients is eligible to curative hematopoietic stem cell (HSC) transplantation, there is an urgent need to develop alternative treatment options. Chronic activation of Wnt/β-catenin has been implicated to underlie MDS formation and recently assigned to drive MDS transformation to acute myeloid leukemia (AML). Wnt/β-catenin signaling therefore may harbor a pha… Show more

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Cited by 6 publications
(2 citation statements)
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References 109 publications
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“…Hallmarks associated with WNT-Beta-Catenin and P53 pathway were also negatively enriched in JAK3-p.V722I lines. Activation of both pathways was reported to be associated with ineffective erythropoiesis and refractory anemia in the context of myelodysplastic neoplasms 25 , 26 .
Fig.
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Section: Resultsmentioning
confidence: 99%
“…Hallmarks associated with WNT-Beta-Catenin and P53 pathway were also negatively enriched in JAK3-p.V722I lines. Activation of both pathways was reported to be associated with ineffective erythropoiesis and refractory anemia in the context of myelodysplastic neoplasms 25 , 26 .
Fig.
…”
Section: Resultsmentioning
confidence: 99%
“…Wnt signaling, usually categorized into canonical and non-canonical pathways, is involved in the process of hematopoiesis. [21][22][23] Notably, the canonical Wnt signaling pathway, which is dependent on the nuclear accumulation of β-catenin to regulate gene transcription, controls primitive hematopoietic progenitor formation and promotes definitive hematopoietic stem cell (HSC) specification. [24][25][26] For instance, it has been demonstrated in Xenopus that, Wnt4-mediated activation of Wnt/β-catenin signaling plays a critical role in the induction and maintenance of primitive hematopoiesis.…”
Section: Introductionmentioning
confidence: 99%