A modularly equipped scanning probe microscope (SPM)-based hybrid system is developed, expanding application fields and performances of former instruments. The SPM head can easily be incorporated into the analysis chamber of most scanning electron microscopes (SEMs) and both systems can be handled by the electronics within one software simultaneously. Contact and non-contact scanning force microscope (SFM) measurements obtained inside an environmental SEM for the first time demonstrate resolutions of less than 0.2 nm under working conditions.Both probes can be used simultaneously either as actuators or sensors to deliberately modify and analyse sample properties as well as to characterize the probe interactions. This is the essential advantage of hybrid systems, besides the great number of well known complementary analyses which can be performed with each microscope at the same sample area. The use of an electron beam and a SFM tip as two independent electrical actuators and sensors is demonstrated to be exemplary. Interaction of the probes with each other is a new aspect, which is presented and discussed.