Capability of polygonum cuspidatum extract in inhibiting AGEs and preventing diabetes

Abstract

Diabetes is a metabolic disorder disease associated with advanced glycation end products (AGEs) and protein glycation. The effect of polygonum cuspidatum extract (PE) on AGEs and Nε‐(Carboxymethyl)‐L‐lysine formation, protein glycation, and diabetes was investigated. Six primary phenolics in a range of 12.36 mg/g for ellagic acid to 0.01 mg/g for piceid were determined in PE. In an intermediate‐moisture‐foods model, inhibition rate of PE was as high as 54.2% for AGEs and 78.9% for CML under aw 0.75. The protein glycation was also inhibited by PE. In a diabetic rat model, the levels of blood glucose, serum malondialdehyde, cholesterol, triglycerides, and low‐density lipoproteins were effectively reduced by PE treatment. The antioxidation capacity (T‐AOC) and superoxide dismutase (SOD) activity were also mediated by PE. Additionally, the activates of liver function‐related enzymes including alkaline phosphatase (ALP), glutamate pyruvate transaminase (GPT), and glutamate oxaloacetate transaminase (GOT) in diabetic rat were improved by PE.

Identification of Molecular Targets and Underlying Mechanisms of Xiaoji Recipe against Pancreatic Cancer Based on Network Pharmacology

“…Curcuma zedoaria (Zingiberaceae) is reported to inhibit the development of gastric carcinoma, breast cancer as well as liver cancer [11][12][13][14]. Polygonum cuspidatum is used for the therapy of multiple diseases including hypertension, diabetes, and atherosclerosis [15][16][17], and its extracts have been reported with anticancer effects in lung cancer, osteosarcoma, and breast cancer [18][19][20]. The extracts of Rhizoma Paridis is revealed to suppress the cancer development in non-small-cell lung carcinoma, colon cancer, and hepatocarcinoma [21][22][23].…”

The Invasive Species Reynoutria japonica Houtt. as a Promising Natural Agent for Cardiovascular and Digestive System Illness

“…Oral gavage PCE was performed in the treatment group at the level of 0.2 g/kg of body weight. Sheng found that PCE could reduce the blood sugar of diabetic rats and make lipid indexes such as LDL-C, HDL-C, and TG tend to be normal ( Sheng et al, 2019 ).…”

Antiglycoxidative Properties of Extracts and Fractions from Reynoutria Rhizomes

“…Previous studies conducted on R. japonica leaf extracts indicate an antiglycation potential of these plants [17]. Moreover, studies in diabetic rats have shown that R. japonica rhizome extract reduced streptozotocin-induced early podocyte damage in the kidneys, and its active ingredient, emodin, inhibited methylglyoxal-mediated protein glycation [18].…”